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Found 1 result for Related Articles by Review for PMID: 31194374
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Alprostadil

Stephen W. Leslie  1 , Ashish Jain  2 , Omar A. Iqbal  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Alprostadil

Stephen W. Leslie et al.
Free Books & Documents

Excerpt

Alprostadil is a synthetic prostaglandin E1 analog primarily used as a second-line treatment for erectile dysfunction in males when oral therapy has failed. This drug is also utilized in specific cases to temporarily maintain the patency of the ductus arteriosus in newborns with congenital heart defects until surgical intervention. For erectile dysfunction, alprostadil is administered via intracavernosal injection or intraurethral suppository, with combination therapies such as "Trimix" offering enhanced efficacy. In neonates, alprostadil’s vasodilatory properties help maintain ductal patency in conditions such as transposition of the great arteries or coarctation of the aorta. The use of this drug requires careful hemodynamic monitoring due to risks of instability. Common adverse effects include hypotension, flushing, and priapism, which require immediate intervention if prolonged.

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Conflict of interest statement

Disclosure: Stephen Leslie declares no relevant financial relationships with ineligible companies.

Disclosure: Ashish Jain declares no relevant financial relationships with ineligible companies.

Disclosure: Omar Iqbal declares no relevant financial relationships with ineligible companies.

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References

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