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    pucM 5-hydroxyisourate hydrolase; also uricase subunit [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 937977, updated on 17-Dec-2024

    Summary

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    Gene symbol
    pucM
    Gene description
    5-hydroxyisourate hydrolase; also uricase subunit
    Locus tag
    BSU_32460
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU32460
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    Genomic context

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    Sequence:
    NC_000964.3 (3334646..3334990)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene uric acid permease subunit Neighboring gene urate oxidase with peroxide reductase N-terminal domain Neighboring gene putative type I toxin Neighboring gene ncRNA Neighboring gene xanthine dehydrogenase, iron-sulfur subunit Neighboring gene xanthine dehydrogenase, substrate and molybdenum cofactor subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family. Jung DK, et al. Proc Natl Acad Sci U S A, 2006 Jun 27. PMID 16782815, Free PMC Article
    2. Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Lee Y, et al. FEBS Lett, 2005 Aug 29. PMID 16098976
    3. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
    4. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746
    5. From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later. Barbe V, et al. Microbiology (Reading), 2009 Jun. PMID 19383706, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that PucM, a transthyretin-related protein, functions to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction.
      Title: Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction.
    2. The crystal structures of PucM at 2.0 A and its complexes with the substrate analogs 8-azaxanthine and 5,6-diaminouracil were reported.
      Title: Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    5-hydroxyisourate hydrolase; also uricase subunit
    NP_391126.2
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_391126.2 5-hydroxyisourate hydrolase; also uricase subunit [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_391126.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAX3RRR3
      Conserved Domains (1) summary
      COG2351
      Location:1 → 114
      HiuH; 5-hydroxyisourate hydrolase (purine catabolism), transthyretin-related family [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O32142.2

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases