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    ppaC inorganic pyrophosphatase (Mn2+-dependent) [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 937817, updated on 6-Oct-2023

    Summary

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    Gene symbol
    ppaC
    Gene description
    inorganic pyrophosphatase (Mn2+-dependent)
    Locus tag
    BSU_40550
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU40550
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    Genomic context

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    Sequence:
    NC_000964.3 (4168204..4169133)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene spore coat protein Neighboring gene transcriptional regulator (Cys-activated by oxidative stress) Neighboring gene putative manganese-binding lipoprotein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of active site mutations on the metal binding affinity, catalytic competence, and stability of the family II pyrophosphatase from Bacillus subtilis. Halonen P, et al. Biochemistry, 2005 Mar 15. PMID 15751976
    2. Structural studies of metal ions in family II pyrophosphatases: the requirement for a Janus ion. Fabrichniy IP, et al. Biochemistry, 2004 Nov 16. PMID 15533045
    3. Site-specific effects of zinc on the activity of family II pyrophosphatase. Zyryanov AB, et al. Biochemistry, 2004 Nov 16. PMID 15533044
    4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
    5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The binuclear metal center, which forms the core of the active site in family II inorganic pyrophosphatase, has a highly integrated structure that is very sensitive to conservative mutations.
      Title: Effects of active site mutations on the metal binding affinity, catalytic competence, and stability of the family II pyrophosphatase from Bacillus subtilis.
    2. A structure-based proposal explains why zinc (Zn2+) in the lower affinity metal site (M1) activates inorganic pyrophosphatase (type II PPase), but Zn2+ in the tight-binding site (M2) activates PPase hardly at all.
      Title: Structural studies of metal ions in family II pyrophosphatases: the requirement for a Janus ion.
    3. The effects of zinc on Bacillus subtilis inorganic phosphatase (PPase) variants suggest that metal-binding subsite M2 is the high-affinity subsite for metal cofactors of family II pyrophosphatases.
      Title: Site-specific effects of zinc on the activity of family II pyrophosphatase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    inorganic pyrophosphatase (Mn2+-dependent)
    NP_391935.1
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_391935.1 inorganic pyrophosphatase (Mn2+-dependent) [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_391935.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0D1L3E7
      Conserved Domains (1) summary
      PRK05427
      Location:1 → 308
      PRK05427; putative manganese-dependent inorganic pyrophosphatase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37487.1

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases