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    rocG glutamate dehydrogenase [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 937066, updated on 6-Oct-2023

    Summary

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    Gene symbol
    rocG
    Gene description
    glutamate dehydrogenase
    Locus tag
    BSU_37790
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU37790
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    Genomic context

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    Sequence:
    NC_000964.3 (3880740..3882014, complement)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene basic aminoacid permease Neighboring gene putative N-deacylase involved in arginine and ornithine utilization Neighboring gene delta-1-pyrroline-5 carboxylate dehydrogenase Neighboring gene biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity Neighboring gene putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat) Neighboring gene putative dTDP-4-dehydrorhamnose reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular properties and enhancement of thermostability by random mutagenesis of glutamate dehydrogenase from Bacillus subtilis. Khan MI, et al. Biosci Biotechnol Biochem, 2005 Oct. PMID 16244435
    2. Regulated expression of HPrK/P does not affect carbon catabolite repression of the xyn operon and of rocG in Bacillus subtilis. Bertram R, et al. FEMS Microbiol Lett, 2006 Jun. PMID 16684115
    3. Glutamate dehydrogenase affects resistance to cell wall antibiotics in Bacillus subtilis. Lee YH, et al. J Bacteriol, 2012 Mar. PMID 22178969, Free PMC Article
    4. A regulatory protein-protein interaction governs glutamate biosynthesis in Bacillus subtilis: the glutamate dehydrogenase RocG moonlights in controlling the transcription factor GltC. Commichau FM, et al. Mol Microbiol, 2007 Aug. PMID 17608797
    5. Hyperphosphorylation of DegU cancels CcpA-dependent catabolite repression of rocG in Bacillus subtilis. Tanaka K, et al. BMC Microbiol, 2015 Feb 22. PMID 25880922, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hyperphosphorylation of DegU cancels CcpA-dependent catabolite repression of rocG in Bacillus subtilis.
      Title: Hyperphosphorylation of DegU cancels CcpA-dependent catabolite repression of rocG in Bacillus subtilis.
    2. The authors conclude that RocG glutamate dehydrogenase activity affects the expression of the sigma(W) regulon, by pathways that are yet unclear.
      Title: Glutamate dehydrogenase affects resistance to cell wall antibiotics in Bacillus subtilis.
    3. The genetic and biochemical data presented here show that the glutamate dehydrogenase RocG is able to bind to and concomitantly inactivate the activator protein GltC.
      Title: A regulatory protein-protein interaction governs glutamate biosynthesis in Bacillus subtilis: the glutamate dehydrogenase RocG moonlights in controlling the transcription factor GltC.
    4. Glutamate dehydrogenase cloned from the rocG gene was characterized for thermostability, oligomerization, and substrate specificity. Random mutagenesis produced an enzyme with missense mutation that enhanced thermostability and k(cat).
      Title: Molecular properties and enhancement of thermostability by random mutagenesis of glutamate dehydrogenase from Bacillus subtilis.
    5. Regulated expression of HPrK/P does not affect carbon catabolite repression of rocG
      Title: Regulated expression of HPrK/P does not affect carbon catabolite repression of the xyn operon and of rocG in Bacillus subtilis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    glutamate dehydrogenase
    NP_391659.2
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      3880740..3882014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_391659.2 glutamate dehydrogenase [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_391659.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0D1IB73
      Conserved Domains (1) summary
      COG0334
      Location:15 → 424
      GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39633.3

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    Other Literature Sources
    Molecular Biology Databases