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    NT5C2 5'-nucleotidase, cytosolic II [ Bos taurus (domestic cattle) ]

    Gene ID: 281951, updated on 20-Feb-2025

    Summary

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    Official Symbol
    NT5C2provided by VGNC
    Official Full Name
    5'-nucleotidase, cytosolic IIprovided by VGNC
    Primary source
    VGNC:VGNC:32291
    See related
    BGD:BT21549; EnsemblRapid:ENSBTAG00070010492
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NT5C2 in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (23739167..23836661, complement)

    Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene arsenite methyltransferase Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 2 Neighboring gene ubiquitin-ribosomal protein eS31 fusion protein-like Neighboring gene chromosome 26 C6orf52 homolog Neighboring gene internexin neuronal intermediate filament protein alpha Neighboring gene polycomb group ring finger 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cytosolic 5'-Nucleotidase II Is a Sensor of Energy Charge and Oxidative Stress: A Possible Function as Metabolic Regulator. Pesi R, et al. Cells, 2021 Jan 18. PMID 33477638, Free PMC Article
    2. Active and regulatory sites of cytosolic 5'-nucleotidase. Pesi R, et al. FEBS J, 2010 Dec. PMID 21029378
    3. Bovine cytosolic IMP/GMP-specific 5'-nucleotidase: cloning and expression of active enzyme in Escherichia coli. Allegrini S, et al. Biochem J, 1997 Dec 1. PMID 9371705, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenosine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytosolic purine 5'-nucleotidase
    Names
    cytosolic 5'-nucleotidase II
    cytosolic IMP/GMP-specific 5'-nucleotidase
    cytosolic nucleoside phosphotransferase 5'N
    NP_776830.1
    XP_005225489.1
    XP_005225491.1
    XP_059737708.1
    XP_059737709.1
    XP_059737710.1
    XP_059737711.1
    XP_059737712.1
    XP_059737713.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174405.2 → NP_776830.1  cytosolic purine 5'-nucleotidase

      See identical proteins and their annotated locations for NP_776830.1

      Status: PROVISIONAL

      Source sequence(s)
      U73690
      UniProtKB/Swiss-Prot
      O46411
      UniProtKB/TrEMBL
      A0A3Q1MSX0, B1H0W4
      Related
      ENSBTAP00070013903.1, ENSBTAT00070023519.1
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 488
      5_nucleotid; 5' nucleotidase family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      23739167..23836661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005225434.5 → XP_005225491.1  cytosolic purine 5'-nucleotidase isoform X3

      See identical proteins and their annotated locations for XP_005225491.1

      UniProtKB/Swiss-Prot
      O46411
      UniProtKB/TrEMBL
      A0A3Q1MSX0, B1H0W4
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 488
      5_nucleotid; 5' nucleotidase family

    2. XM_005225432.5 → XP_005225489.1  cytosolic purine 5'-nucleotidase isoform X1

      See identical proteins and their annotated locations for XP_005225489.1

      UniProtKB/TrEMBL
      A0A3Q1MSX0, A0AAF7AMR3
      Related
      ENSBTAP00070013891.1, ENSBTAT00070023504.1
      Conserved Domains (1) summary
      pfam05761
      Location:43 → 496
      5_nucleotid; 5' nucleotidase family

    3. XM_059881725.1 → XP_059737708.1  cytosolic purine 5'-nucleotidase isoform X2

      UniProtKB/TrEMBL
      A0A452DIK1
      Related
      ENSBTAP00070013876.1, ENSBTAT00070023483.1

    4. XM_059881726.1 → XP_059737709.1  cytosolic purine 5'-nucleotidase isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MUV3
      Related
      ENSBTAP00070013866.1, ENSBTAT00070023472.1

    5. XM_059881727.1 → XP_059737710.1  cytosolic purine 5'-nucleotidase isoform X5

      UniProtKB/TrEMBL
      A0A3Q1ML41
      Related
      ENSBTAP00070013860.1, ENSBTAT00070023463.1

    6. XM_059881730.1 → XP_059737713.1  cytosolic purine 5'-nucleotidase isoform X6

    7. XM_059881728.1 → XP_059737711.1  cytosolic purine 5'-nucleotidase isoform X6

    8. XM_059881729.1 → XP_059737712.1  cytosolic purine 5'-nucleotidase isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46411.1 GenPept UniProtKB/Swiss-Prot:O46411

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