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    mdhB L-2-hydroxycarboxylate dehydrogenase [ Methanocaldococcus jannaschii DSM 2661 ]

    Gene ID: 1451352, updated on 22-Oct-2024

    Summary

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    Gene symbol
    mdhB
    Gene description
    L-2-hydroxycarboxylate dehydrogenase
    Locus tag
    MJ_RS02590
    Gene type
    protein coding
    RefSeq status
    PIPELINE
    Organism
    Methanocaldococcus jannaschii DSM 2661 (strain: DSM 2661, type-material: type strain of Methanocaldococcus jannaschii)
    Lineage
    Archaea; Methanobacteriati; Methanobacteriota; Methanomada group; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus
    Old locus tag
    MJ0490; MJ_0490
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    Genomic context

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    Sequence:
    NC_000909.1 (433725..434666)

    NC_000909.1Genomic Context describing neighboring genes Neighboring gene DUF3236 domain-containing protein Neighboring gene SAM-dependent methyltransferase HcgC family protein Neighboring gene DUF2120 family protein Neighboring gene hypothetical protein Neighboring gene carboxylating nicotinate-nucleotide diphosphorylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000909.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the MJ0490 gene product of the hyperthermophilic archaebacterium Methanococcus jannaschii, a novel member of the lactate/malate family of dehydrogenases. Lee BI, et al. J Mol Biol, 2001 Apr 13. PMID 11292347
    2. The putative L-lactate dehydrogenase from Methanococcus jannaschii is an NADPH-dependent L-malate dehydrogenase. Madern D. Mol Microbiol, 2000 Sep. PMID 10998181
    3. Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix. Kawakami R, et al. Biochim Biophys Acta, 2009 Oct. PMID 19555779
    4. Differences in the oligomeric states of the LDH-like L-MalDH from the hyperthermophilic archaea Methanococcus jannaschii and Archaeoglobus fulgidus. Madern D, et al. Biochemistry, 2001 Aug 28. PMID 11513609
    5. Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea. Graupner M, et al. J Bacteriol, 2000 Jul. PMID 10850983, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    L-2-hydroxycarboxylate dehydrogenase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000909.1 Reference assembly

      Range
      433725..434666
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_010869991.1 L-2-hydroxycarboxylate dehydrogenase [Methanocaldococcus jannaschii]

      See identical proteins and their annotated locations for WP_010869991.1

      Status: PIPELINE

      UniProtKB/Swiss-Prot
      Q60176
      Conserved Domains (1) summary
      cd05294
      Location:1 → 310
      LDH-like_MDH_nadp; A lactate dehydrogenases-like structure with malate dehydrogenase enzymatic activity
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60176.1

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