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    CNGA3 cyclic nucleotide gated channel subunit alpha 3 [ Ovis aries (sheep) ]

    Gene ID: 100233164, updated on 3-Dec-2024

    Summary

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    Gene symbol
    CNGA3
    Gene description
    cyclic nucleotide gated channel subunit alpha 3
    See related
    EnsemblRapid:ENSOARG00020015072
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    See CNGA3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 3 NC_056056.1 (102835910..102877356, complement)

    Chromosome 3 - NC_056056.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly factor 5 Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene inositol polyphosphate-4-phosphatase type I A Neighboring gene von Willebrand factor A domain containing 3B Neighboring gene transmembrane protein 131

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056056.1 Chromosome 3 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Ovis aries Rambouillet Genome sequencing and assembly
    • BioProject: PRJNA414087
    • Analysis date: Thu Jan 09 10:41:41 2025

    Bibliography

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    Related articles in PubMed

    1. A mutation in gene CNGA3 is associated with day blindness in sheep. Reicher S, et al. Genomics, 2010 Feb. PMID 19874885
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mutation in gene CNGA3 is associated with day blindness in sheep
      Title: A mutation in gene CNGA3 is associated with day blindness in sheep.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cGMP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables intracellularly cAMP-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables intracellularly cGMP-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic nucleotide-gated cation channel alpha-3
    Names
    cyclic nucleotide gated channel alpha 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056056.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      102835910..102877356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027965727.2 → XP_027821528.2  cyclic nucleotide-gated cation channel alpha-3 isoform X2

      UniProtKB/TrEMBL
      C3W948
      Conserved Domains (2) summary
      PLN03192
      Location:181 → 614
      PLN03192; Voltage-dependent potassium channel; Provisional
      cl09111
      Location:614 → 685
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    2. XM_042245151.1 → XP_042101085.1  cyclic nucleotide-gated cation channel alpha-3 isoform X2

      UniProtKB/TrEMBL
      C3W948
      Conserved Domains (2) summary
      PLN03192
      Location:181 → 614
      PLN03192; Voltage-dependent potassium channel; Provisional
      cl09111
      Location:614 → 685
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    3. XM_060413953.1 → XP_060269936.1  cyclic nucleotide-gated cation channel alpha-3 isoform X2

      UniProtKB/TrEMBL
      C3W948

    4. XM_042245153.2 → XP_042101087.1  cyclic nucleotide-gated cation channel alpha-3 isoform X4

      UniProtKB/TrEMBL
      C3W948
      Related
      ENSOARP00020019062.2, ENSOART00020022987.2
      Conserved Domains (3) summary
      PLN03192
      Location:174 → 607
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:496 → 612
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl09111
      Location:607 → 678
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    5. XM_042245152.2 → XP_042101086.1  cyclic nucleotide-gated cation channel alpha-3 isoform X3

      UniProtKB/TrEMBL
      C3W948
      Related
      ENSOARP00020060377.1, ENSOART00020066821.1
      Conserved Domains (2) summary
      PLN03192
      Location:173 → 609
      PLN03192; Voltage-dependent potassium channel; Provisional
      cl09111
      Location:609 → 680
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    6. XM_042245150.2 → XP_042101084.1  cyclic nucleotide-gated cation channel alpha-3 isoform X1

      UniProtKB/TrEMBL
      C3W948
      Related
      ENSOARP00020019130.2, ENSOART00020023067.2
      Conserved Domains (3) summary
      PLN03192
      Location:212 → 645
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:534 → 650
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl09111
      Location:645 → 716
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001143663.1: Suppressed sequence

      Description
      NM_001143663.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: CNGA3 (GeneID:1261).
    Nucleotide Protein Strain
    Heading Accession and Version

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