PMC

A) Synchronized 3D sPLS-DA plots of overall plasma metabolomics profiles. Red dots represent individual non-CF controls, green dots represent CF patients without SHSe, and blue dots represent CF patients with SHSe. B) Synchronized 3D sPLS-DA plots of overall CF plasma metabolomics profiles stratified by age and SHSe. Red dots represent individual CF children without SHSe, dark blue dots represent CF children with SHSe, green dots represent CF infants without SHSe, and light blue dots represent CF infants with SHSe. The top 3 components are presented on the X, Y and Z axes for comparisons in 1A and 1B. C) 2D sPLS-DA plot of overall metabolomics profiles for comparison of CF infants with and without SHSe. CF infants with SHSe are shown in green, and CF infants without SHSe are shown in red. D) 2D sPLS-DA plot of overall metabolomics profiles for comparison of CF children with and without SHSe. CF children with SHSe are shown in green, and CF children without SHSe are shown in red. The top 2 components are presented on the X and Y axes for comparisons in 1C and 1D.

Distance comparisons were made for microbiota of: (a) Uninfected control (NIC) and CF baseline, (b) NIC and Exacerbated CF, (c) NIC and After Treatment of Exacerbated CF, (d) NIC and On Treatment of Exacerbated CF, (e) NIC and Before Treatment of Exacerbated CF, (f) CF baseline and Exacerbated CF, (g) Before, During and After Treatment of Exacerbated CF, (h) CF baseline and Before, During, After Treatment of Exacerbated CF. Each point represents a sample from the studies listed in . The color for each sample group can be found on the figure.

Collection sites and hydrographic basin of occurrence of Leporinus cf. friderici. Colored circles represent the MOTUs found in this study: L. agassizii (red), L. cf. friderici Amazon 1 (orange), L. cf. friderici Madeira 1 (purple), L. cf. friderici Paraná (light green), L. cf. friderici Paraguay (dark green), L. piau São Francisco (dark blue), L. cf. friderici Upper Tapajós (yellow), and L. cf. friderici Tocantins 1 (light blue). Black dot represents individuals collected as L. cf. friderici Amazon 2; black star represents L. cf. friderici Mearim; black square represents L. cf. friderici Tocantins 2; black polygon represents L. cf. friderici Madeira 2; black triangle represents L. cf. friderici Xingú. A, Prior Sete Quedas waterfalls region and Itaipú dam. B, Teotônio falls in the Madeira River. Map created by Q-GIS (http://www.qgis.org/). The collection site numbers are according to Supplementary Table .

a Multi-colored CF yarns prepared using the one-step HTC of glucose. b Photograph of a multi-colored CF yarn. c Schematic illustration of the production process of colored CF fabric from multi-colored CF yarn. d Weaving process of preparing colored CF fabric. e Photograph of a package of multi-colored CF yarn. f Photograph of the weaving machine. g Photograph for the weaving process of the multi-colored CF fabric. h A piece of 15 × 15 cm² plain weave fabric formed by industrial weaving machines.