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Select item 118766011.

Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response

Stefanie Höfer, Larissa Frasch, Sarah Brajkovic, Kerstin Putzker, Joe Lewis, Hendrik Schürmann, Valentina Leone, Amirhossein Sakhteman, Matthew The, Florian P Bayer, Julian Müller, Firas Hamood, Jens T Siveke, Maximilian Reichert, Bernhard Kuster

Mol Syst Biol. 2025 Mar; 21(3): 231–253. Published online 2025 Jan 21. doi: 10.1038/s44320-025-00085-6

PMCID:: PMC11876601

Article PDF–7.1M

Select item 118766302.

Epigenetic modifications and metabolic gene mutations drive resistance evolution in response to stimulatory antibiotics

Hui Lin, Donglin Wang, Qiaojuan Wang, Jie Mao, Lutong Yang, Yaohui Bai, Jiuhui Qu

Mol Syst Biol. 2025 Mar; 21(3): 294–314. Published online 2025 Jan 16. doi: 10.1038/s44320-025-00087-4

PMCID:: PMC11876630

Article PDF–6.0M

Select item 117909493.

A multiplex method for rapidly identifying viral protease inhibitors

Seo Jung Hong, Samuel J Resnick, Sho Iketani, Ji Won Cha, Benjamin Alexander Albert, Christopher T Fazekas, Ching-Wen Chang, Hengrui Liu, Shlomi Dagan, Michael R Abagyan, Pavla Fajtová, Bruce Culbertson, Brooklyn Brace, Eswar R Reddem, Farhad Forouhar, J Fraser Glickman, James M Balkovec, Brent R Stockwell, Lawrence Shapiro, Anthony J O’Donoghue, Yosef Sabo, Joel S Freundlich, David D Ho, Alejandro Chavez

Mol Syst Biol. 2025 Feb; 21(2): 158–172. Published online 2025 Jan 6. doi: 10.1038/s44320-024-00082-1

PMCID:: PMC11790949

Article PDF–1.3M

Select item 118766314.

Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks

Paul Lubrano, Fabian Smollich, Thorben Schramm, Elisabeth Lorenz, Alejandra Alvarado, Seraina Carmen Eigenmann, Amelie Stadelmann, Sevvalli Thavapalan, Nils Waffenschmidt, Timo Glatter, Nadine Hoffmann, Jennifer Müller, Silke Peter, Knut Drescher, Hannes Link

Mol Syst Biol. 2025 Mar; 21(3): 274–293. Published online 2025 Jan 2. doi: 10.1038/s44320-024-00084-z

PMCID:: PMC11876631

Article PDF–4.3M

Select item 117909375.

High order expression dependencies finely resolve cryptic states and subtypes in single cell data

Abel Jansma, Yuelin Yao, Jareth Wolfe, Luigi Del Debbio, Sjoerd V Beentjes, Chris P Ponting, Ava Khamseh

Mol Syst Biol. 2025 Feb; 21(2): 173–207. Published online 2025 Jan 2. doi: 10.1038/s44320-024-00074-1

PMCID:: PMC11790937

Article PDF–7.3M

Select item 117910706.

Oncogenic PIK3CA corrupts growth factor signaling specificity

Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

Mol Syst Biol. 2025 Feb; 21(2): 126–157. Published online 2024 Dec 20. doi: 10.1038/s44320-024-00078-x

PMCID:: PMC11791070

Article PDF–8.4M

Select item 116974027.

State of the interactomes: an evaluation of molecular networks for generating biological insights

Sarah N Wright, Scott Colton, Leah V Schaffer, Rudolf T Pillich, Christopher Churas, Dexter Pratt, Trey Ideker

Mol Syst Biol. 2025 Jan; 21(1): 1–29. Published online 2024 Dec 9. doi: 10.1038/s44320-024-00077-y

PMCID:: PMC11697402

Article PDF–6.5M

Select item 116124298.

Understanding the biological processes of kidney carcinogenesis: an integrative multi-omics approach

Ricardo Cortez Cardoso Penha, Alexandra Sexton Oates, Sergey Senkin, Hanla A Park, Joshua Atkins, Ivana Holcatova, Anna Hornakova, Slavisa Savic, Simona Ognjanovic, Beata Świątkowska, Jolanta Lissowska, David Zaridze, Anush Mukeria, Vladimir Janout, Amelie Chabrier, Vincent Cahais, Cyrille Cuenin, Ghislaine Scelo, Matthieu Foll, Zdenko Herceg, Paul Brennan, Karl Smith-Byrne, Nicolas Alcala, James D Mckay

Mol Syst Biol. 2024 Dec; 20(12): 1282–1302. Published online 2024 Nov 26. doi: 10.1038/s44320-024-00072-3

PMCID:: PMC11612429

Article PDF–4.0M

Select item 116969849.

Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors

Deepak T Patel, Peter J Stogios, Lukasz Jaroszewski, Malene L Urbanus, Mayya Sedova, Cameron Semper, Cathy Le, Abraham Takkouche, Keita Ichii, Julie Innabi, Dhruvin H Patel, Alexander W Ensminger, Adam Godzik, Alexei Savchenko

Mol Syst Biol. 2025 Jan; 21(1): 59–89. Published online 2024 Nov 19. doi: 10.1038/s44320-024-00076-z

PMCID:: PMC11696984

Article PDF–4.9M

Select item 1161190910.

Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting

David Steinbrecht, Igor Minia, Miha Milek, Johannes Meisig, Nils Blüthgen, Markus Landthaler

Mol Syst Biol. 2024 Dec; 20(12): 1346–1371. Published online 2024 Nov 15. doi: 10.1038/s44320-024-00073-2

PMCID:: PMC11611909

Article PDF–6.2M

Select item 1161214411.

Deep quantification of substrate turnover defines protease subsite cooperativity

Rajani Kanth Gudipati, Dimos Gaidatzis, Jan Seebacher, Sandra Muehlhaeusser, Georg Kempf, Simone Cavadini, Daniel Hess, Charlotte Soneson, Helge Großhans

Mol Syst Biol. 2024 Dec; 20(12): 1303–1328. Published online 2024 Oct 28. doi: 10.1038/s44320-024-00071-4

PMCID:: PMC11612144

Article PDF–7.0M

Select item 1161230712.

Bacterial live therapeutics for human diseases

Elisabet Frutos-Grilo, Yamile Ana, Javier Gonzalez-de Miguel, Marcel Cardona-i-Collado, Irene Rodriguez-Arce, Luis Serrano

Mol Syst Biol. 2024 Dec; 20(12): 1261–1281. Published online 2024 Oct 23. doi: 10.1038/s44320-024-00067-0

PMCID:: PMC11612307

Article PDF–2.4M

Select item 1153533413.

High-throughput protein characterization by complementation using DNA barcoded fragment libraries

Bradley W Biggs, Morgan N Price, Dexter Lai, Jasmine Escobedo, Yuridia Fortanel, Yolanda Y Huang, Kyoungmin Kim, Valentine V Trotter, Jennifer V Kuehl, Lauren M Lui, Romy Chakraborty, Adam M Deutschbauer, Adam P Arkin

Mol Syst Biol. 2024 Nov; 20(11): 1207–1229. Published online 2024 Oct 7. doi: 10.1038/s44320-024-00068-z

PMCID:: PMC11535334

Article PDF–3.0M

Select item 1153506914.

Correction of a widespread bias in pooled chemical genomics screens improves their interpretability

Lili M Kim, Horia Todor, Carol A Gross

Mol Syst Biol. 2024 Nov; 20(11): 1173–1186. Published online 2024 Sep 30. doi: 10.1038/s44320-024-00069-y

PMCID:: PMC11535069

Article PDF–2.6M

Select item 1153527515.

Author Correction: Predictive evolution of metabolic phenotypes using model-designed environments

Paula Jouhten, Dimitrios Konstantinidis, Filipa Pereira, Sergej Andrejev, Kristina Grkovska, Sandra Castillo, Payam Ghiaci, Gemma Beltran, Eivind Almaas, Albert Mas, Jonas Warringer, Ramon Gonzalez, Pilar Morales, Kiran R Patil

Mol Syst Biol. 2024 Nov; 20(11): 1260. Published online 2024 Sep 25. doi: 10.1038/s44320-024-00066-1

Corrects:: Mol Syst Biol. 2022 Oct; 18(10): e10980.

PMCID:: PMC11535275

Correction PDF–344K

Select item 1153524816.

Tissue-aware interpretation of genetic variants advances the etiology of rare diseases

Chanan M Argov, Ariel Shneyour, Juman Jubran, Eric Sabag, Avigdor Mansbach, Yair Sepunaru, Emmi Filtzer, Gil Gruber, Miri Volozhinsky, Yuval Yogev, Ohad Birk, Vered Chalifa-Caspi, Lior Rokach, Esti Yeger-Lotem

Mol Syst Biol. 2024 Nov; 20(11): 1187–1206. Published online 2024 Sep 16. doi: 10.1038/s44320-024-00061-6

PMCID:: PMC11535248

Article PDF–4.0M

Select item 1145022317.

Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes

Payam Ghiaci, Paula Jouhten, Nikolay Martyushenko, Helena Roca-Mesa, Jennifer Vázquez, Dimitrios Konstantinidis, Simon Stenberg, Sergej Andrejev, Kristina Grkovska, Albert Mas, Gemma Beltran, Eivind Almaas, Kiran R Patil, Jonas Warringer

Mol Syst Biol. 2024 Oct; 20(10): 1109–1133. Published online 2024 Aug 22. doi: 10.1038/s44320-024-00059-0