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Select item 117022871.

NMR structures of small molecules bound to a model of an RNA CUG repeat expansion

Jonathan L. Chen, Amirhossein Taghavi, Alexander J. Frank, Matthew A. Fountain, Shruti Choudhary, Soma Roy, Jessica L. Childs-Disney, Matthew D. Disney

Bioorg Med Chem Lett. Author manuscript; available in PMC 2025 Jan 6.

Published in final edited form as: Bioorg Med Chem Lett. 2024 Oct 1; 111: 129888. Published online 2024 Jul 14. doi: 10.1016/j.bmcl.2024.129888

PMCID:: PMC11702287

Article PDF–2.3M

Select item 110348002.

Cytotoxic leuconoxine-type diazaspiroindole alkaloids isolated from Cryptolepis dubia

Yulin Ren, Elizabeth N. Kaweesa, Joshua M. Henkin, Kongmany Sydara, Mouachanh Xayvue, Pankaj Pandey, Amar Gopal Chittiboyina, Zulfiqar Ali, Daneel Ferreira, Djaja D. Soejarto, Joanna E. Burdette, A. Douglas Kinghorn

Bioorg Med Chem Lett. Author manuscript; available in PMC 2025 Mar 15.

Published in final edited form as: Bioorg Med Chem Lett. 2024 Mar 15; 101: 129650. Published online 2024 Feb 9. doi: 10.1016/j.bmcl.2024.129650

PMCID:: PMC11034800

Article PDF–772K

Select item 108089813.

Synthesis and structure–activity relationships of aryl fluorosulfate-based inhibitors as novel antitubercular agents

Baiyuan Yang, Paridhi Sukheja, Bo Qin, Gencheng Li, Grant A.L. Bare, Alessandro Cascioferro, Melissa S. Love, H. Michael Petrassi, K. Barry Sharpless, Case W. McNamara, Arnab K. Chatterjee

Bioorg Med Chem Lett. 2024 Jan 15; 98: 129596. doi: 10.1016/j.bmcl.2023.129596

PMCID:: PMC10808981

Article PDF–664K

Select item 109519754.

Design, synthesis, and evaluation of dual EGFR/AURKB inhibitors as anticancer agents for non-small cell lung cancer

Sonali Kurup, Dayna Gesinski, Kaitlin Assaad, Aidan Reynolds

Bioorg Med Chem Lett. Author manuscript; available in PMC 2024 Mar 20.

Published in final edited form as: Bioorg Med Chem Lett. 2024 Mar 1; 100: 129612. Published online 2024 Jan 8. doi: 10.1016/j.bmcl.2024.129612

PMCID:: PMC10951975

Article PDF–2.1M

Select item 108722135.

Expanded Library of Novel 2,3-Pyrrolidinedione Analogues Exhibit Anti-biofilm Activity

Minhua Nie, M. Alejandro Valdes-Pena, Bram H. Frohock, Emma Smits, Jennifer C. Daiker, Jessica M. Gilbertie, Lauren V. Schnabel, Joshua G. Pierce

Bioorg Med Chem Lett. Author manuscript; available in PMC 2025 Feb 1.

Published in final edited form as: Bioorg Med Chem Lett. 2024 Feb 1; 99: 129609. Published online 2024 Jan 6. doi: 10.1016/j.bmcl.2024.129609

PMCID:: PMC10872213

Article PDF–688K

Select item 108420946.

Imidazole-Based Sphingosine-1-phosphate Transporter Spns2 Inhibitors

Christopher W. Shrader, Daniel Foster, Yugesh Kharel, Tao Huang, Kevin R. Lynch, Webster L. Santos

Bioorg Med Chem Lett. Author manuscript; available in PMC 2024 Nov 15.

Published in final edited form as: Bioorg Med Chem Lett. 2023 Nov 15; 96: 129516. Published online 2023 Oct 11. doi: 10.1016/j.bmcl.2023.129516

PMCID:: PMC10842094

Article PDF–778K

Select item 106391137.

Discovery of a Non-Covalent Ligand for Rpn-13, a Therapeutic Target for Hematological Cancers

Cody A. Loy, Christine S. Muli, Eslam M. H. Ali, Dan Xie, Mostafa H. Ahmed, Carol Beth Post, Darci J. Trader

Bioorg Med Chem Lett. Author manuscript; available in PMC 2024 Oct 15.

Published in final edited form as: Bioorg Med Chem Lett. 2023 Oct 15; 95: 129485. Published online 2023 Sep 14. doi: 10.1016/j.bmcl.2023.129485

PMCID:: PMC10639113

Article PDF–1.1M

Select item 105290628.

Identification of covalent fragment inhibitors for Plasmodium falciparum UCHL3 with anti-malarial efficacy

Ryan D. Imhoff, Melissa R. Rosenthal, Kutub Ashraf, Purnima Bhanot, Caroline L. Ng, Daniel P. Flaherty

Bioorg Med Chem Lett. Author manuscript; available in PMC 2024 Oct 1.

Published in final edited form as: Bioorg Med Chem Lett. 2023 Oct 1; 94: 129458. Published online 2023 Aug 25. doi: 10.1016/j.bmcl.2023.129458

PMCID:: PMC10529062

Article PDF–580K

Select item 105298369.

Novel series of tunable μOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications

Alok Nerurkar, Thomas Nguyen, Sheldon Wang, Ulhas Bhatt, Kevin Li, Yihong Li, Pingyu Ding, Frederick J. Seidl, Martin Holan, John Lee, Tien Widjaja, Zhi-Liang Wei, Corinne Sadlowski, David Sperandio, Lawrence R. McGee, Beth Youngblood, Neil Schwartz, Donald Gehlert, Julio C. Medina

Bioorg Med Chem Lett. Author manuscript; available in PMC 2024 Aug 15.

Published in final edited form as: Bioorg Med Chem Lett. 2023 Aug 15; 92: 129405. Published online 2023 Jul 5. doi: 10.1016/j.bmcl.2023.129405

PMCID:: PMC10529836

Article PDF–1.6M

Select item 1100345010.

Structure-property relationships of fluorinated carboxylic acid bioisosteres

Thibault Alle, Sipak Joyasawal, Killian Oukoloff, Keith Long, Zachary Owyang, Karol R. Francisco, Dominique Cahard, Donna M. Huryn, Carlo Ballatore

Bioorg Med Chem Lett. Author manuscript; available in PMC 2024 Apr 9.

Published in final edited form as: Bioorg Med Chem Lett. 2023 Jul 15; 91: 129363. Published online 2023 Jun 8. doi: 10.1016/j.bmcl.2023.129363

PMCID:: PMC11003450

Article PDF–601K

Select item 1033092311.

Synthesis and biological evaluation of biotinylated ZJ-101

Shan Qian, Sarah A. Head, Phillip R. Sanchez, Jun O. Liu, Zhendong Jin

Bioorg Med Chem Lett. Author manuscript; available in PMC 2024 Jul 15.

Published in final edited form as: Bioorg Med Chem Lett. 2023 Jul 15; 91: 129372. Published online 2023 Jun 8. doi: 10.1016/j.bmcl.2023.129372

PMCID:: PMC10330923

Article PDF–559K

Select item 1129806912.

Visible light-Activated Prodrug System with a Novel Heavy-atom-Free Photosensitizer

Shudan Yang, Lushun Wang, Axel Loredo, Shichao Wang, Nischal Ada, Han Xiao

Bioorg Med Chem Lett. Author manuscript; available in PMC 2024 Aug 4.

Published in final edited form as: Bioorg Med Chem Lett. 2023 Jul 15; 91: 129365. Published online 2023 Jun 7. doi: 10.1016/j.bmcl.2023.129365

PMCID:: PMC11298069

Article PDF–1.1M

Select item 1040824013.

A Method for Tritiation of Iboxamycin Permits Measurement of its Ribosomal Binding

Kelvin J.Y. Wu, Dorota Klepacki, Alexander S. Mankin, Andrew G. Myers

Bioorg Med Chem Lett. Author manuscript; available in PMC 2024 Jul 15.

Published in final edited form as: Bioorg Med Chem Lett. 2023 Jul 15; 91: 129364. Published online 2023 Jun 7. doi: 10.1016/j.bmcl.2023.129364

PMCID:: PMC10408240

Article PDF–488K

Select item 1050643914.

Identification of new hit to lead magmas inhibitors as potential therapeutics for glioblastoma

Bhaskar C. Das, Javier J. Lepe, Mohammed Adil Shareef, Naomi Lomeli, Sasmita Das, Daniela A. Bota

Bioorg Med Chem Lett. Author manuscript; available in PMC 2023 Sep 18.

Published in final edited form as: Bioorg Med Chem Lett. 2023 Jul 15; 91: 129330. Published online 2023 May 16. doi: 10.1016/j.bmcl.2023.129330

PMCID:: PMC10506439

Article PDF–1.1M

Select item 1017689115.

Discovery of novel bicyclic[3.3.0]proline peptidyl α-ketoamides as potent 3CL-protease inhibitors for SARS-CoV-2

Xiaoxin Chen, Peng Li, Jianzhou Huang, Yaxun Yang, Haoyu Zhang, Zheng Wang, Zhenzhen Zhu, Jingjing Wang, Jianchen Zhang, Kevin Chen, Haiying He, Chaofeng Long, Shuhui Chen

Bioorg Med Chem Lett. 2023 Jun 15; 90: 129324. Published online 2023 May 12. doi: 10.1016/j.bmcl.2023.129324

PMCID:: PMC10176891

Article PDF–1.8M

Select item 1030844316.

Development of a fluorescence screening assay for binding partners of the iron-sulfur mitochondrial protein mitoNEET

Ebenezer Newton, Sarah A. Starcovic, Michael Menze, Mary E. Konkle, Timothy E. Long, Lori A. Hazlehurst, Jason D. Huber, Aaron R. Robart, Werner J. Geldenhuys

Bioorg Med Chem Lett. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Bioorg Med Chem Lett. 2023 Jun 1; 89: 129310. Published online 2023 May 1. doi: 10.1016/j.bmcl.2023.129310

PMCID:: PMC10308443

Article PDF–910K

Select item 1039507117.

Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS

Cayden J. Dodd, Keagan S. Chronister, Upendra Rathnayake, Lauren C. Parr, Kangjun Li, Sichen Chang, Dehui Mi, Emily L. Days, Joshua A. Bauer, Hyekyung P. Cho, Olivier Boutaud, Jerod S. Denton, Craig W. Lindsley, Changho Han

Bioorg Med Chem Lett. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Bioorg Med Chem Lett. 2023 May 1; 87: 129256. Published online 2023 Mar 24. doi: 10.1016/j.bmcl.2023.129256