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Select item 108457961.

Gastrointestinal Delivery of an mRNA Vaccine Using Immunostimulatory Polymeric Nanoparticles

Hyunjoon Kim, Ameya R. Kirtane, Na Yoon Kim, Netra Unni Rajesh, Chaoyang Tang, Keiko Ishida, Alison M. Hayward, Robert Langer, Giovanni Traverso

AAPS J. Author manuscript; available in PMC 2024 Feb 17.

Published in final edited form as: AAPS J. 2023 Aug 17; 25(5): 81. Published online 2023 Aug 17. doi: 10.1208/s12248-023-00844-z

PMCID:: PMC10845796

Article PDF–1.6M

Select item 101416602.

Plasma stability and plasma metabolite concentration-time profiles of oligo(lactic acid)8-paclitaxel prodrug loaded polymeric micelles

Lauren Repp, Sarah L. Skoczen, Morteza Rasoulianboroujeni, Stephan T. Stern, Glen S. Kwon

AAPS J. Author manuscript; available in PMC 2024 Apr 11.

Published in final edited form as: AAPS J. 2023 Apr 11; 25(3): 39. Published online 2023 Apr 11. doi: 10.1208/s12248-023-00807-4

PMCID:: PMC10141660

Article PDF–1.4M

Select item 108323273.

The Uses and Advantages of Kirchhoff’s Laws vs. Differential Equations in Pharmacology, Pharmacokinetics, and (Even) Chemistry

Leslie Z. Benet, Jasleen K. Sodhi

AAPS J. Author manuscript; available in PMC 2024 Apr 10.

Published in final edited form as: AAPS J. 2023 Apr 10; 25(3): 38. Published online 2023 Apr 10. doi: 10.1208/s12248-023-00801-w

PMCID:: PMC10832327

Article PDF–441K

Select item 103509004.

Vinyl Sulfone-functionalized Acetalated Dextran Microparticles as a Subunit Broadly Acting Influenza Vaccine

Cole J. Batty, Liubov M. Lifshits, Dylan A. Hendy, Meital Eckshtain-Levi, Luis A. Ontiveros-Padilla, Michael A. Carlock, Ted M. Ross, Eric M. Bachelder, Kristy M. Ainslie

AAPS J. Author manuscript; available in PMC 2023 Jul 17.

Published in final edited form as: AAPS J. 2023 Jan 31; 25(1): 22. Published online 2023 Jan 31. doi: 10.1208/s12248-023-00786-6

PMCID:: PMC10350900

Article PDF–1.0M

Select item 109027955.

Theoretical Examination Seeking Tangible Physical Meanings of Slopes and Intercepts of Plasma Concentration–Time Relationships in Minimal Physiologically Based Pharmacokinetic Models

Yoo-Seong Jeong, William J. Jusko

AAPS J. Author manuscript; available in PMC 2024 Feb 29.

Published in final edited form as: AAPS J. 2023 Jan 26; 25(1): 19. Published online 2023 Jan 26. doi: 10.1208/s12248-022-00779-x

PMCID:: PMC10902795

Article PDF–2.2M

Select item 106950106.

Pancreatic hormone insulin modulates organic anion transporter 1 in the kidney: regulation via remote sensing and signaling network

Zhou Yu, Jinghui Zhang, Zhengxuan Liang, Jingjing Wu, Kexin Liu, Guofeng You

AAPS J. Author manuscript; available in PMC 2024 Jan 10.

Published in final edited form as: AAPS J. 2023 Jan 10; 25(1): 13. Published online 2023 Jan 10. doi: 10.1208/s12248-022-00778-y

PMCID:: PMC10695010

Article PDF–1.1M

Select item 100345797.

Development and Validation of a Western Blot Method to Quantify Mini-Dystrophin in Human Skeletal Muscle Biopsies

Catherine I. Soderstrom, Jennifer Larsen, Carolina Owen, David Gifondorwa, David Beidler, Florence H. Yong, Patricia Conrad, Hendrik Neubert, Steven A. Moore, Mohamed Hassanein

AAPS J. Author manuscript; available in PMC 2023 Mar 23.

Published in final edited form as: AAPS J. 2022 Dec 20; 25(1): 12. Published online 2022 Dec 20. doi: 10.1208/s12248-022-00776-0

PMCID:: PMC10034579

Article PDF–981K

Select item 96298858.

Determination of Anti-drug Antibody Affinity in Clinical Study Samples Provides a Tool for Evaluation of Immune Response Maturation

Alison Joyce, Christopher Shea, Zhiping You, Boris Gorovits, Christopher Lepsy

AAPS J. 2022 Nov; 24(6): 114. Published online 2022 Nov 2. doi: 10.1208/s12248-022-00759-1

PMCID:: PMC9629885

Article PDF–2.7M

Select item 95897429.

Benchmarking the Quality Practices of Global Pharmaceutical Manufacturing to Advance Supply Chain Resilience

Matt Fellows, Thomas Friedli, Ye Li, Jennifer Maguire, Nandini Rakala, Marten Ritz, Matteo Bernasconi, Mark Seiss, Neil Stiber, Mat Swatek, Alex Viehmann

AAPS J. 2022 Nov; 24(6): 111. Published online 2022 Oct 20. doi: 10.1208/s12248-022-00761-7

PMCID:: PMC9589742

Article PDF–915K

Select item 1075464110.

Pharmacokinetics and Pharmacodynamics of TAK-164 Antibody Drug Conjugate Coadministered with Unconjugated Antibody

Bruna Menezes, Eshita Khera, Melissa Calopiz, Michael D. Smith, Michelle L. Ganno, Cornelius Cilliers, Adnan O. Abu-Yousif, Jennifer J. Linderman, Greg M. Thurber

AAPS J. Author manuscript; available in PMC 2023 Dec 28.

Published in final edited form as: AAPS J. 2022 Oct 7; 24(6): 107. Published online 2022 Oct 7. doi: 10.1208/s12248-022-00756-4

PMCID:: PMC10754641

Article PDF–1.9M

Select item 943926311.

Usage of Compartmental Models in Predicting COVID-19 Outbreaks

Peijue Zhang, Kairui Feng, Yuqing Gong, Jieon Lee, Sara Lomonaco, Liang Zhao

AAPS J. 2022 Sep; 24(5): 98. Published online 2022 Sep 2. doi: 10.1208/s12248-022-00743-9

PMCID:: PMC9439263

Article PDF–1.4M

Select item 920304612.

Capillary-Mediated Vitrification: Preservation of mRNA at Elevated Temperatures

Sankar Renu, Mary Shank-Retzlaff, Jenny Sharpe, Laura Bronsart, Pravansu Mohanty

AAPS J. 2022 Jul; 24(4): 75. Published online 2022 Jun 16. doi: 10.1208/s12248-022-00723-z

PMCID:: PMC9203046

Article PDF–1.1M

Select item 904440313.

Targeted delivery of endosomal escape peptides to enhance immunotoxin potency and anti-cancer efficacy

Joseph Ryan Polli, Ping Chen, Brandon M. Bordeau, Joseph P. Balthasar

AAPS J. Author manuscript; available in PMC 2022 Apr 27.

Published in final edited form as: AAPS J. 2022 Mar 25; 24(3): 47. Published online 2022 Mar 25. doi: 10.1208/s12248-022-00698-x

PMCID:: PMC9044403

Article PDF–1.2M

Select item 892042114.

Biological Matrix Supply Chain Shortages: More Matrices Are Now Rare—the Case for Surrogate Matrices

Evan A. Dubiel, Heather Myler, Mark E. Arnold, Patrick Bennett, Jeff Gatz, Elizabeth Groeber, Seema Gupta, Cheikh Kane, Fumin Li, William Mylott, Courtney Noah, Mark O’Dell, Eric Tewalt, Dominic Warrino, Andrew Vick

AAPS J. 2022 Mar; 24(2): 42. Published online 2022 Mar 14. doi: 10.1208/s12248-022-00694-1

PMCID:: PMC8920421

Article PDF–354K

Select item 886588315.

State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References

Giovanni Bocci, Tudor I. Oprea, Leslie Z. Benet

AAPS J. 2022 Mar; 24(2): 37. Published online 2022 Feb 23. doi: 10.1208/s12248-022-00687-0

PMCID:: PMC8865883

Article PDF–1.1M

Select item 882186416.

Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions

Aditya R. Kolli, Tanja Zivkovic Semren, David Bovard, Shoaib Majeed, Marco van der Toorn, Sophie Scheuner, Philippe A. Guy, Arkadiusz Kuczaj, Anatoly Mazurov, Stefan Frentzel, Florian Calvino-Martin, Nikolai V. Ivanov, John O’Mullane, Manuel C. Peitsch, Julia Hoeng

AAPS J. 2022 Feb; 24(1): 33. Published online 2022 Feb 7. doi: 10.1208/s12248-021-00666-x

PMCID:: PMC8821864

Article PDF–7.1M

Select item 881705817.

In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition

Yukiko Murata, Sibylle Neuhoff, Amin Rostami-Hodjegan, Hiroyuki Takita, Zubida M. Al-Majdoub, Kayode Ogungbenro

AAPS J. 2022 Feb; 24(1): 28. Published online 2022 Jan 13. doi: 10.1208/s12248-021-00675-w

PMCID:: PMC8817058

Article PDF–901K

Select item 874113718.

Nano/microparticle Formulations for Universal Influenza Vaccines

Dylan A. Hendy, Eva A. Amouzougan, Isabella C. Young, Eric M. Bachelder, Kristy M. Ainslie

AAPS J. 2022 Jan; 24(1): 24. Published online 2022 Jan 7. doi: 10.1208/s12248-021-00676-9

PMCID:: PMC8741137

Article PDF–958K

Select item 881710219.

A Full Evaporation Static Headspace Gas Chromatography Method with Nitrogen Phosphorous Detection for Ultrasensitive Analysis of Semi-volatile Nitrosamines in Pharmaceutical Products

Jinjian Zheng, Christine L. Kirkpatrick, Daniel Lee, Xinxin Han, Ana I. Martinez, Kimberly Gallagher, Rebecca K. Evans, Sanjay V. Mudur, Xihui Liang, Jennifer Drake, Leah A. Buhler, Mark D. Mowery

AAPS J. 2022 Feb; 24(1): 23. Published online 2022 Jan 6. doi: 10.1208/s12248-021-00669-8