Alternative titles; symbols
HGNC Approved Gene Symbol: PRY2
Cytogenetic location: Yq11.223 Genomic coordinates (GRCh38) : Y:22,071,706-22,084,875 (from NCBI)
Lahn and Page (1997) isolated PRY2 among testis cDNAs corresponding to genes located in the nonrecombining portion of the Y chromosome. PRY2 is 1 of 3 PRY genes they identified in this region. Northern blot analysis of several tissues detected PRY expression only in testis.
By analysis of a panel of partial Y chromosomes, Lahn and Page (1997) mapped PRY genes to regions 6C (PRY2) and 6E (PRY1; 400019) on the long arm of the Y chromosome, and to region 4A on Yp. Skaletsky et al. (2003) determined that the region of chromosome Yq containing PRY1 and PRY2 is palindromic.
Repping et al. (2004) identified the b2/b3 deletion within the AZFc region (415000) of the Y chromosome, in which both PRY1 and PRY2 are deleted. The b2/b3 deletion has no obvious effect on fitness.
Lahn, B. T., Page, D. C. Functional coherence of the human Y chromosome. Science 278: 675-680, 1997. [PubMed: 9381176] [Full Text: https://doi.org/10.1126/science.278.5338.675]
Repping, S., van Daalen, S. K. M., Korver, C. M., Brown, L. G., Marszalek, J. D., Gianotten, J., Oates, R. D., Silber, S., van der Veen, F., Page, D. C., Rozen, S. A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. Genomics 83: 1046-1052, 2004. [PubMed: 15177557] [Full Text: https://doi.org/10.1016/j.ygeno.2003.12.018]
Skaletsky, H., Kuroda-Kawaguchi, T., Minx, P. J., Cordum, H. S., Hillier, L., Brown, L. G., Repping, S., Pyntikova, T., Ali, J., Bieri, T., Chinwalla, A., Delehaunty, A., and 28 others. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 423: 825-837, 2003. [PubMed: 12815422] [Full Text: https://doi.org/10.1038/nature01722]