Alternative titles; symbols
HGNC Approved Gene Symbol: PRY
Cytogenetic location: Yq11.223 Genomic coordinates (GRCh38) : Y:22,490,397-22,514,637 (from NCBI)
Lahn and Page (1997) isolated testis cDNAs corresponding to genes located in the nonrecombining portion of the Y chromosome (NRY). See BPY1 (400012). They identified 7 novel genes that exist in multiple copies on the Y chromosome and are expressed specifically in testis. Transcripts from 2 of these genes, TTY1 (testis transcript on Y chromosome, gene 1) and TTY2, do not contain a significant open reading frame. A third gene, PRY (PTPBL-related protein on Y), encodes a protein that shares some similarity to the mouse protein tyrosine phosphatase PTPBL, a homolog of human PTPN13 (600267). The authors speculated that the selective advantage conferred by the NRY's retention and amplification of male fertility factors accounts for the multitude of testis-specific gene families there.
By analysis of a panel of partial Y chromosomes, Lahn and Page (1997) mapped PRY genes to regions 6C (PRY2; 400041) and 6E (PRY1) on the long arm of the human Y chromosome, and to region 4A on Yp. Yen (1998) detected 3 PRY genes in the proximal portion of Y-chromosome deletion interval 6. Each PRY gene was close to a TTY2 gene.
Skaletsky et al. (2003) determined that the region of chromosome Yq containing PRY1 and PRY2 is palindromic.
Repping et al. (2004) identified the b2/b3 deletion within the AZFc region (415000) of the Y chromosome, in which both PRY1 and PRY2 are deleted. The b2/b3 deletion has no obvious effect on fitness.
Lahn, B. T., Page, D. C. Functional coherence of the human Y chromosome. Science 278: 675-680, 1997. [PubMed: 9381176] [Full Text: https://doi.org/10.1126/science.278.5338.675]
Repping, S., van Daalen, S. K. M., Korver, C. M., Brown, L. G., Marszalek, J. D., Gianotten, J., Oates, R. D., Silber, S., van der Veen, F., Page, D. C., Rozen, S. A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. Genomics 83: 1046-1052, 2004. [PubMed: 15177557] [Full Text: https://doi.org/10.1016/j.ygeno.2003.12.018]
Skaletsky, H., Kuroda-Kawaguchi, T., Minx, P. J., Cordum, H. S., Hillier, L., Brown, L. G., Repping, S., Pyntikova, T., Ali, J., Bieri, T., Chinwalla, A., Delehaunty, A., and 28 others. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 423: 825-837, 2003. [PubMed: 12815422] [Full Text: https://doi.org/10.1038/nature01722]
Yen, P. H. A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males. Genomics 54: 5-12, 1998. [PubMed: 9806824] [Full Text: https://doi.org/10.1006/geno.1998.5526]