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Primary low grade serous adenocarcinoma of ovary

MedGen UID:
928025
•Concept ID:
C4302356
•
Neoplastic Process
SNOMED CT: Primary low grade serous adenocarcinoma of ovary (722684000)

Professional guidelines

PubMed

Stage, treatment and survival of low-grade serous ovarian carcinoma in the Netherlands: A nationwide study.
De Decker K, Wenzel HHB, Bart J, van der Aa MA, Kruitwagen RFPM, Nijman HW, Kruse AJ
Acta Obstet Gynecol Scand 2023 Mar;102(3):246-256. Epub 2023 Feb 3 doi: 10.1111/aogs.14518. PMID: 36734363Free PMC Article
Contemporary primary treatment of women with stage II-IV low-grade serous ovarian/peritoneal cancer (LGSOC): Determinants of relapse and disease-free survival.
Gershenson DM, Cobb LP, Westin SN, Zhang Y, Jazaeri A, Malpica A, Sun CC
Gynecol Oncol 2022 Nov;167(2):139-145. Epub 2022 Sep 20 doi: 10.1016/j.ygyno.2022.09.005. PMID: 36137845
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690

Recent clinical studies

Etiology

Stage, treatment and survival of low-grade serous ovarian carcinoma in the Netherlands: A nationwide study.
De Decker K, Wenzel HHB, Bart J, van der Aa MA, Kruitwagen RFPM, Nijman HW, Kruse AJ
Acta Obstet Gynecol Scand 2023 Mar;102(3):246-256. Epub 2023 Feb 3 doi: 10.1111/aogs.14518. PMID: 36734363Free PMC Article
Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
MILO/ENGOT-ov11: Binimetinib Versus Physician's Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum.
Monk BJ, Grisham RN, Banerjee S, Kalbacher E, Mirza MR, Romero I, Vuylsteke P, Coleman RL, Hilpert F, Oza AM, Westermann A, Oehler MK, Pignata S, Aghajanian C, Colombo N, Drill E, Cibula D, Moore KN, Christy-Bittel J, Del Campo JM, Berger R, Marth C, Sehouli J, O'Malley DM, Churruca C, Boyd AP, Kristensen G, Clamp A, Ray-Coquard I, Vergote I
J Clin Oncol 2020 Nov 10;38(32):3753-3762. Epub 2020 Aug 21 doi: 10.1200/JCO.20.01164. PMID: 32822286Free PMC Article
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691

Diagnosis

Stage, treatment and survival of low-grade serous ovarian carcinoma in the Netherlands: A nationwide study.
De Decker K, Wenzel HHB, Bart J, van der Aa MA, Kruitwagen RFPM, Nijman HW, Kruse AJ
Acta Obstet Gynecol Scand 2023 Mar;102(3):246-256. Epub 2023 Feb 3 doi: 10.1111/aogs.14518. PMID: 36734363Free PMC Article
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Serous and mucinous borderline (low malignant potential) tumors of the ovary.
Acs G
Am J Clin Pathol 2005 Jun;123 Suppl:S13-57. doi: 10.1309/J6PXXK1HQJAEBVPM. PMID: 16100867

Therapy

Basket study of oral progesterone antagonist onapristone extended release in progesterone receptor-positive recurrent granulosa cell, low-grade serous ovarian cancer, or endometrioid endometrial cancer.
Andres S, Finch L, Iasonos A, Zhou Q, Girshman J, Chhetri-Long R, Green H, Jang D, O'Cearbhaill R, Kyi C, Cohen S, Friedman C, Makker V, Chi DS, Sonoda Y, Chiang S, Aghajanian C, Weigelt B, Grisham RN
Gynecol Oncol 2024 Oct;189:30-36. Epub 2024 Jul 10 doi: 10.1016/j.ygyno.2024.06.026. PMID: 38991472Free PMC Article
Targeted Therapies in Low-Grade Serous Ovarian Cancers.
Gonzalez A, Nagel CI, Haight PJ
Curr Treat Options Oncol 2024 Jul;25(7):854-868. Epub 2024 Jun 13 doi: 10.1007/s11864-024-01205-4. PMID: 38869696Free PMC Article
Phase II trial of pembrolizumab and epacadostat in recurrent clear cell carcinoma of the ovary: An NRG oncology study GY016.
Gien LT, Enserro DM, Block MS, Waggoner S, Duska LR, Wahner-Hendrickson AE, Thaker PH, Backes F, Kidd M, Muller CY, DiSilvestro PA, Covens A, Gershenson DM, Moore KN, Aghajanian C, Coleman RL
Gynecol Oncol 2024 Jul;186:61-68. Epub 2024 Apr 10 doi: 10.1016/j.ygyno.2024.03.027. PMID: 38603953Free PMC Article
MILO/ENGOT-ov11: Binimetinib Versus Physician's Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum.
Monk BJ, Grisham RN, Banerjee S, Kalbacher E, Mirza MR, Romero I, Vuylsteke P, Coleman RL, Hilpert F, Oza AM, Westermann A, Oehler MK, Pignata S, Aghajanian C, Colombo N, Drill E, Cibula D, Moore KN, Christy-Bittel J, Del Campo JM, Berger R, Marth C, Sehouli J, O'Malley DM, Churruca C, Boyd AP, Kristensen G, Clamp A, Ray-Coquard I, Vergote I
J Clin Oncol 2020 Nov 10;38(32):3753-3762. Epub 2020 Aug 21 doi: 10.1200/JCO.20.01164. PMID: 32822286Free PMC Article
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252

Prognosis

Factors associated with the involvement of lymph nodes in low-grade serous ovarian cancer.
Durmuş Y, Meydanlı MM, Akıllı H, Kayıkçıoğlu F, Güngördük K, Akbayır Ö, Taşkın S, Çelik H, Ayhan A
J Surg Oncol 2022 Feb;125(2):264-272. Epub 2021 Oct 5 doi: 10.1002/jso.26700. PMID: 34610148
MILO/ENGOT-ov11: Binimetinib Versus Physician's Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum.
Monk BJ, Grisham RN, Banerjee S, Kalbacher E, Mirza MR, Romero I, Vuylsteke P, Coleman RL, Hilpert F, Oza AM, Westermann A, Oehler MK, Pignata S, Aghajanian C, Colombo N, Drill E, Cibula D, Moore KN, Christy-Bittel J, Del Campo JM, Berger R, Marth C, Sehouli J, O'Malley DM, Churruca C, Boyd AP, Kristensen G, Clamp A, Ray-Coquard I, Vergote I
J Clin Oncol 2020 Nov 10;38(32):3753-3762. Epub 2020 Aug 21 doi: 10.1200/JCO.20.01164. PMID: 32822286Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Hormone receptor expression profile of low-grade serous ovarian cancers.
Buttarelli M, Mascilini F, Zannoni GF, Ciucci A, Martinelli E, Filippetti F, Scambia G, Ferrandina G, Gallo D
Gynecol Oncol 2017 May;145(2):352-360. Epub 2017 Feb 20 doi: 10.1016/j.ygyno.2017.02.029. PMID: 28228232
Serous and mucinous borderline (low malignant potential) tumors of the ovary.
Acs G
Am J Clin Pathol 2005 Jun;123 Suppl:S13-57. doi: 10.1309/J6PXXK1HQJAEBVPM. PMID: 16100867

Clinical prediction guides

Stage, treatment and survival of low-grade serous ovarian carcinoma in the Netherlands: A nationwide study.
De Decker K, Wenzel HHB, Bart J, van der Aa MA, Kruitwagen RFPM, Nijman HW, Kruse AJ
Acta Obstet Gynecol Scand 2023 Mar;102(3):246-256. Epub 2023 Feb 3 doi: 10.1111/aogs.14518. PMID: 36734363Free PMC Article
Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
MILO/ENGOT-ov11: Binimetinib Versus Physician's Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum.
Monk BJ, Grisham RN, Banerjee S, Kalbacher E, Mirza MR, Romero I, Vuylsteke P, Coleman RL, Hilpert F, Oza AM, Westermann A, Oehler MK, Pignata S, Aghajanian C, Colombo N, Drill E, Cibula D, Moore KN, Christy-Bittel J, Del Campo JM, Berger R, Marth C, Sehouli J, O'Malley DM, Churruca C, Boyd AP, Kristensen G, Clamp A, Ray-Coquard I, Vergote I
J Clin Oncol 2020 Nov 10;38(32):3753-3762. Epub 2020 Aug 21 doi: 10.1200/JCO.20.01164. PMID: 32822286Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Hormone receptor expression profile of low-grade serous ovarian cancers.
Buttarelli M, Mascilini F, Zannoni GF, Ciucci A, Martinelli E, Filippetti F, Scambia G, Ferrandina G, Gallo D
Gynecol Oncol 2017 May;145(2):352-360. Epub 2017 Feb 20 doi: 10.1016/j.ygyno.2017.02.029. PMID: 28228232

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