U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Alzheimer disease 17(AD17)

MedGen UID:
767366
•Concept ID:
C3554452
•
Disease or Syndrome
Synonyms: AD17; ALZHEIMER DISEASE 17, LATE-ONSET
 
Gene (location): TREM2 (6p21.1)
 
Monarch Initiative: MONDO:0014036
OMIM®: 615080

Definition

A form of Alzheimer''s disease associated with mutation(s) in the TREM2 gene, encoding triggering receptor expressed on myeloid cells 2. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlzheimer disease 17

Professional guidelines

PubMed

Brexpiprazole for the Treatment of Agitation in Alzheimer Dementia: A Randomized Clinical Trial.
Lee D, Slomkowski M, Hefting N, Chen D, Larsen KG, Kohegyi E, Hobart M, Cummings JL, Grossberg GT
JAMA Neurol 2023 Dec 1;80(12):1307-1316. doi: 10.1001/jamaneurol.2023.3810. PMID: 37930669Free PMC Article
Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts.
McKee AC, Stein TD, Huber BR, Crary JF, Bieniek K, Dickson D, Alvarez VE, Cherry JD, Farrell K, Butler M, Uretsky M, Abdolmohammadi B, Alosco ML, Tripodis Y, Mez J, Daneshvar DH
Acta Neuropathol 2023 Apr;145(4):371-394. Epub 2023 Feb 10 doi: 10.1007/s00401-023-02540-w. PMID: 36759368Free PMC Article
Research criteria for the diagnosis of prodromal dementia with Lewy bodies.
McKeith IG, Ferman TJ, Thomas AJ, Blanc F, Boeve BF, Fujishiro H, Kantarci K, Muscio C, O'Brien JT, Postuma RB, Aarsland D, Ballard C, Bonanni L, Donaghy P, Emre M, Galvin JE, Galasko D, Goldman JG, Gomperts SN, Honig LS, Ikeda M, Leverenz JB, Lewis SJG, Marder KS, Masellis M, Salmon DP, Taylor JP, Tsuang DW, Walker Z, Tiraboschi P; prodromal DLB Diagnostic Study Group
Neurology 2020 Apr 28;94(17):743-755. Epub 2020 Apr 2 doi: 10.1212/WNL.0000000000009323. PMID: 32241955Free PMC Article

Recent clinical studies

Etiology

Association between Mediterranean diet and dementia and Alzheimer disease: a systematic review with meta-analysis.
Nucci D, Sommariva A, Degoni LM, Gallo G, Mancarella M, Natarelli F, Savoia A, Catalini A, Ferranti R, Pregliasco FE, Castaldi S, Gianfredi V
Aging Clin Exp Res 2024 Mar 22;36(1):77. doi: 10.1007/s40520-024-02718-6. PMID: 38519775Free PMC Article
ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies.
Raulin AC, Doss SV, Trottier ZA, Ikezu TC, Bu G, Liu CC
Mol Neurodegener 2022 Nov 8;17(1):72. doi: 10.1186/s13024-022-00574-4. PMID: 36348357Free PMC Article
Biological subtypes of Alzheimer disease: A systematic review and meta-analysis.
Ferreira D, Nordberg A, Westman E
Neurology 2020 Mar 10;94(10):436-448. Epub 2020 Feb 11 doi: 10.1212/WNL.0000000000009058. PMID: 32047067Free PMC Article
When Does Alzheimer's Disease Really Start? The Role of Biomarkers.
Lloret A, Esteve D, Lloret MA, Cervera-Ferri A, Lopez B, Nepomuceno M, Monllor P
Int J Mol Sci 2019 Nov 6;20(22) doi: 10.3390/ijms20225536. PMID: 31698826Free PMC Article
Neurodegeneration and Neuro-Regeneration-Alzheimer's Disease and Stem Cell Therapy.
Vasic V, Barth K, Schmidt MHH
Int J Mol Sci 2019 Aug 31;20(17) doi: 10.3390/ijms20174272. PMID: 31480448Free PMC Article

Diagnosis

Lecanemab (Leqembi) for Alzheimer's disease.
Med Lett Drugs Ther 2023 Feb 6;65(1669):17-18. doi: 10.58347/tml.2023.1669a. PMID: 36757347
Behavioural and psychological symptoms of dementia in patients with Alzheimer's disease and family caregiver burden: a path analysis.
Kim B, Noh GO, Kim K
BMC Geriatr 2021 Mar 5;21(1):160. doi: 10.1186/s12877-021-02109-w. PMID: 33663416Free PMC Article
MRI Radiomics Classification and Prediction in Alzheimer's Disease and Mild Cognitive Impairment: A Review.
Feng Q, Ding Z
Curr Alzheimer Res 2020;17(3):297-309. doi: 10.2174/1567205017666200303105016. PMID: 32124697
When Does Alzheimer's Disease Really Start? The Role of Biomarkers.
Lloret A, Esteve D, Lloret MA, Cervera-Ferri A, Lopez B, Nepomuceno M, Monllor P
Int J Mol Sci 2019 Nov 6;20(22) doi: 10.3390/ijms20225536. PMID: 31698826Free PMC Article
Synaptic degeneration and neurogranin in the pathophysiology of Alzheimer's disease.
Lista S, Hampel H
Expert Rev Neurother 2017 Jan;17(1):47-57. Epub 2016 Jul 1 doi: 10.1080/14737175.2016.1204234. PMID: 27332958

Therapy

Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers: A Secondary Analysis of a Randomized Clinical Trial.
Brum WS, Docherty KF, Ashton NJ, Zetterberg H, Hansson O, McMurray JJV, Blennow K
JAMA Neurol 2024 Feb 1;81(2):197-200. doi: 10.1001/jamaneurol.2023.4719. PMID: 38109077Free PMC Article
Brexpiprazole for the Treatment of Agitation in Alzheimer Dementia: A Randomized Clinical Trial.
Lee D, Slomkowski M, Hefting N, Chen D, Larsen KG, Kohegyi E, Hobart M, Cummings JL, Grossberg GT
JAMA Neurol 2023 Dec 1;80(12):1307-1316. doi: 10.1001/jamaneurol.2023.3810. PMID: 37930669Free PMC Article
Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia.
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337Free PMC Article
β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology.
Shippy DC, Wilhelm C, Viharkumar PA, Raife TJ, Ulland TK
J Neuroinflammation 2020 Sep 21;17(1):280. doi: 10.1186/s12974-020-01948-5. PMID: 32958021Free PMC Article
Efficacy and Safety of Brexpiprazole for the Treatment of Agitation in Alzheimer's Dementia: Two 12-Week, Randomized, Double-Blind, Placebo-Controlled Trials.
Grossberg GT, Kohegyi E, Mergel V, Josiassen MK, Meulien D, Hobart M, Slomkowski M, Baker RA, McQuade RD, Cummings JL
Am J Geriatr Psychiatry 2020 Apr;28(4):383-400. Epub 2019 Oct 1 doi: 10.1016/j.jagp.2019.09.009. PMID: 31708380

Prognosis

Causal relationship between Alzheimer's disease and cardiovascular disease: a bidirectional Mendelian randomization analysis.
Zhang F, Xian D, Feng J, Ning L, Jiang T, Xu W, Liu Y, Zhao Q, Peng M
Aging (Albany NY) 2023 Sep 2;15(17):9022-9040. doi: 10.18632/aging.205013. PMID: 37665672Free PMC Article
2021 Alzheimer's disease facts and figures.
Alzheimers Dement 2021 Mar;17(3):327-406. Epub 2021 Mar 23 doi: 10.1002/alz.12328. PMID: 33756057
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.
Groveman BR, Orrù CD, Hughson AG, Raymond LD, Zanusso G, Ghetti B, Campbell KJ, Safar J, Galasko D, Caughey B
Acta Neuropathol Commun 2018 Feb 9;6(1):7. doi: 10.1186/s40478-018-0508-2. PMID: 29422107Free PMC Article
Synaptic degeneration and neurogranin in the pathophysiology of Alzheimer's disease.
Lista S, Hampel H
Expert Rev Neurother 2017 Jan;17(1):47-57. Epub 2016 Jul 1 doi: 10.1080/14737175.2016.1204234. PMID: 27332958
Effect of aromatherapy on patients with Alzheimer's disease.
Jimbo D, Kimura Y, Taniguchi M, Inoue M, Urakami K
Psychogeriatrics 2009 Dec;9(4):173-9. doi: 10.1111/j.1479-8301.2009.00299.x. PMID: 20377818

Clinical prediction guides

Brexpiprazole for the Treatment of Agitation in Alzheimer Dementia: A Randomized Clinical Trial.
Lee D, Slomkowski M, Hefting N, Chen D, Larsen KG, Kohegyi E, Hobart M, Cummings JL, Grossberg GT
JAMA Neurol 2023 Dec 1;80(12):1307-1316. doi: 10.1001/jamaneurol.2023.3810. PMID: 37930669Free PMC Article
Causal relationship between Alzheimer's disease and cardiovascular disease: a bidirectional Mendelian randomization analysis.
Zhang F, Xian D, Feng J, Ning L, Jiang T, Xu W, Liu Y, Zhao Q, Peng M
Aging (Albany NY) 2023 Sep 2;15(17):9022-9040. doi: 10.18632/aging.205013. PMID: 37665672Free PMC Article
Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial.
Vossel K, Ranasinghe KG, Beagle AJ, La A, Ah Pook K, Castro M, Mizuiri D, Honma SM, Venkateswaran N, Koestler M, Zhang W, Mucke L, Howell MJ, Possin KL, Kramer JH, Boxer AL, Miller BL, Nagarajan SS, Kirsch HE
JAMA Neurol 2021 Nov 1;78(11):1345-1354. doi: 10.1001/jamaneurol.2021.3310. PMID: 34570177Free PMC Article
Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus.
Bettcher BM, Tansey MG, Dorothée G, Heneka MT
Nat Rev Neurol 2021 Nov;17(11):689-701. Epub 2021 Sep 14 doi: 10.1038/s41582-021-00549-x. PMID: 34522039Free PMC Article
Behavioural and psychological symptoms of dementia in patients with Alzheimer's disease and family caregiver burden: a path analysis.
Kim B, Noh GO, Kim K
BMC Geriatr 2021 Mar 5;21(1):160. doi: 10.1186/s12877-021-02109-w. PMID: 33663416Free PMC Article

Recent systematic reviews

Effects of motor-cognitive training on dual-task performance in people with Parkinson's disease: a systematic review and meta-analysis.
Johansson H, Folkerts AK, Hammarström I, Kalbe E, Leavy B
J Neurol 2023 Jun;270(6):2890-2907. Epub 2023 Feb 23 doi: 10.1007/s00415-023-11610-8. PMID: 36820916Free PMC Article
The gut microbiota-brain axis, psychobiotics and its influence on brain and behaviour: A systematic review.
Barrio C, Arias-Sánchez S, Martín-Monzón I
Psychoneuroendocrinology 2022 Mar;137:105640. Epub 2021 Dec 17 doi: 10.1016/j.psyneuen.2021.105640. PMID: 34942539
Analysis the Link between Periodontal Diseases and Alzheimer's Disease: A Systematic Review.
Borsa L, Dubois M, Sacco G, Lupi L
Int J Environ Res Public Health 2021 Sep 3;18(17) doi: 10.3390/ijerph18179312. PMID: 34501899Free PMC Article
Menopausal hormone therapy and women's health: An umbrella review.
Zhang GQ, Chen JL, Luo Y, Mathur MB, Anagnostis P, Nurmatov U, Talibov M, Zhang J, Hawrylowicz CM, Lumsden MA, Critchley H, Sheikh A, Lundbäck B, Lässer C, Kankaanranta H, Lee SH, Nwaru BI
PLoS Med 2021 Aug;18(8):e1003731. Epub 2021 Aug 2 doi: 10.1371/journal.pmed.1003731. PMID: 34339416Free PMC Article
The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer's Disease-A Review.
van den Brink AC, Brouwer-Brolsma EM, Berendsen AAM, van de Rest O
Adv Nutr 2019 Nov 1;10(6):1040-1065. doi: 10.1093/advances/nmz054. PMID: 31209456Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • Gene
      Related information in NCBI Gene
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...