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Bacteremia, susceptibility to, 2(BACTS2)

MedGen UID:
482277
•Concept ID:
C3280647
•
Finding
Synonym: BACTS2
 
Gene (location): CISH (3p21.2)
 
Monarch Initiative: MONDO:0013724
OMIM®: 614383

Definition

Any bacteremia, susceptibility in which the cause of the disease is a mutation in the CISH gene. [from MONDO]

Professional guidelines

PubMed

Global Differences in the Management of Staphylococcus aureus Bacteremia: No International Standard of Care.
Westgeest AC, Buis DTP, Sigaloff KCE, Ruffin F, Visser LG, Yu Y, Schippers EF, Lambregts MMC, Tong SYC, de Boer MGJ, Fowler VG
Clin Infect Dis 2023 Oct 13;77(8):1092-1101. doi: 10.1093/cid/ciad363. PMID: 37310693Free PMC Article
Cefazolin in the treatment of central nervous system infections: A narrative review and recommendation.
Antosz K, Battle S, Chang J, Scheetz MH, Al-Hasan M, Bookstaver PB
Pharmacotherapy 2023 Jan;43(1):85-95. Epub 2023 Jan 22 doi: 10.1002/phar.2750. PMID: 36521869
Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group.
Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, Bolger A, Cabell CH, Takahashi M, Baltimore RS, Newburger JW, Strom BL, Tani LY, Gerber M, Bonow RO, Pallasch T, Shulman ST, Rowley AH, Burns JC, Ferrieri P, Gardner T, Goff D, Durack DT; American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee; American Heart Association Council on Cardiovascular Disease in the Young; American Heart Association Council on Clinical Cardiology; American Heart Association Council on Cardiovascular Surgery and Anesthesia; Quality of Care and Outcomes Research Interdisciplinary Working Group
Circulation 2007 Oct 9;116(15):1736-54. Epub 2007 Apr 19 doi: 10.1161/CIRCULATIONAHA.106.183095. PMID: 17446442

Recent clinical studies

Etiology

Carbapenem combination therapy versus standard of care for persistent methicillin-susceptible Staphylococcus aureus bacteraemia.
Shah S, Clarke LG, Ludwig J, Burgdorf S, Arbulu Guerra RD, Shields RK
J Antimicrob Chemother 2024 Aug 1;79(8):1990-1997. doi: 10.1093/jac/dkae198. PMID: 38946294
Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial.
Omrani AS, Abujarir SH, Ben Abid F, Shaar SH, Yilmaz M, Shaukat A, Alsamawi MS, Elgara MS, Alghazzawi MI, Shunnar KM, Zaqout A, Aldeeb YM, Alfouzan W, Almaslamani MA; SOAB Study Group
Clin Microbiol Infect 2024 Apr;30(4):492-498. Epub 2023 Oct 18 doi: 10.1016/j.cmi.2023.10.014. PMID: 37858867
Mortality in KPC-producing Klebsiella pneumoniae bloodstream infections: a changing landscape.
Giacobbe DR, Marelli C, Cattardico G, Fanelli C, Signori A, Di Meco G, Di Pilato V, Mikulska M, Mazzitelli M, Cattelan AM, Pallotto C, Francisci D, Calabresi A, Lombardi A, Gori A, Del Bono V, Aldieri C, Losito AR, Raffaelli F, Cortegiani A, Milazzo M, Del Puente F, Pontali E, De Rosa FG, Corcione S, Mularoni A, Russelli G, Giacomini M, Badalucco Ciotta F, Oltolini C, Serino FS, Momesso E, Spinicci M, Graziani L, Torti C, Trecarichi EM, Merli M, D'Amico F, Marchese A, Vena A, Bassetti M
J Antimicrob Chemother 2023 Oct 3;78(10):2505-2514. doi: 10.1093/jac/dkad262. PMID: 37606528
Severe Pneumonia Caused by Methicillin-Resistant Staphylococcus pseudintermedius in an Oncology Patient: Case Report and Literature Review.
Asleh M, Feinstein Y, Lazar I, Rokney A, Baum M, Sagi O, Leibovitz E, Danino D
Microb Drug Resist 2022 Feb;28(2):222-228. Epub 2021 Oct 4 doi: 10.1089/mdr.2020.0469. PMID: 34609906
Are all beta-lactams similarly effective in the treatment of methicillin-sensitive Staphylococcus aureus bacteraemia?
Paul M, Zemer-Wassercug N, Talker O, Lishtzinsky Y, Lev B, Samra Z, Leibovici L, Bishara J
Clin Microbiol Infect 2011 Oct;17(10):1581-6. Epub 2010 Dec 14 doi: 10.1111/j.1469-0691.2010.03425.x. PMID: 21073629

Diagnosis

A systematic review on the excess health risk of antibiotic-resistant bloodstream infections for six key pathogens in Europe.
Hassoun-Kheir N, Guedes M, Ngo Nsoga MT, Argante L, Arieti F, Gladstone BP, Kingston R, Naylor NR, Pezzani MD, Pouwels KB, Robotham JV, Rodríguez-Baño J, Tacconelli E, Vella V, Harbarth S, de Kraker MEA; PrIMAVeRa Workpackage 1
Clin Microbiol Infect 2024 Mar;30 Suppl 1:S14-S25. Epub 2023 Oct 4 doi: 10.1016/j.cmi.2023.09.001. PMID: 37802750
Performance of the Reveal Rapid Antibiotic Susceptibility Testing System on Gram-Negative Blood Cultures at a Large Urban Hospital.
Tibbetts R, George S, Burwell R, Rajeev L, Rhodes PA, Singh P, Samuel L
J Clin Microbiol 2022 Jun 15;60(6):e0009822. Epub 2022 May 24 doi: 10.1128/jcm.00098-22. PMID: 35607972Free PMC Article
Extensively drug-resistant Alcaligenes faecalis infection.
Huang C
BMC Infect Dis 2020 Nov 11;20(1):833. doi: 10.1186/s12879-020-05557-8. PMID: 33176714Free PMC Article
Bloodstream infections in critically ill patients: an expert statement.
Timsit JF, Ruppé E, Barbier F, Tabah A, Bassetti M
Intensive Care Med 2020 Feb;46(2):266-284. Epub 2020 Feb 11 doi: 10.1007/s00134-020-05950-6. PMID: 32047941Free PMC Article
Bloodstream infections - Standard and progress in pathogen diagnostics.
Lamy B, Sundqvist M, Idelevich EA; ESCMID Study Group for Bloodstream Infections, Endocarditis and Sepsis (ESGBIES)
Clin Microbiol Infect 2020 Feb;26(2):142-150. Epub 2019 Nov 22 doi: 10.1016/j.cmi.2019.11.017. PMID: 31760113

Therapy

Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial.
López-Cortés LE, Delgado-Valverde M, Moreno-Mellado E, Goikoetxea Aguirre J, Guio Carrión L, Blanco Vidal MJ, López Soria LM, Pérez-Rodríguez MT, Martínez Lamas L, Arnaiz de Las Revillas F, Armiñanzas C, Ruiz de Alegría-Puig C, Jiménez Aguilar P, Del Carmen Martínez-Rubio M, Sáez-Bejar C, de Las Cuevas C, Martín-Aspas A, Galán F, Yuste JR, Leiva-León J, Bou G, Capón González P, Boix-Palop L, Xercavins-Valls M, Goenaga-Sánchez MÁ, Anza DV, Castón JJ, Rufián MR, Merino E, Rodríguez JC, Loeches B, Cuervo G, Guerra Laso JM, Plata A, Pérez Cortés S, López Mato P, Sierra Monzón JL, Rosso-Fernández C, Bravo-Ferrer JM, Retamar-Gentil P, Rodríguez-Baño J; SIMPLIFY study group
Lancet Infect Dis 2024 Apr;24(4):375-385. Epub 2024 Jan 9 doi: 10.1016/S1473-3099(23)00686-2. PMID: 38215770
Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial.
Omrani AS, Abujarir SH, Ben Abid F, Shaar SH, Yilmaz M, Shaukat A, Alsamawi MS, Elgara MS, Alghazzawi MI, Shunnar KM, Zaqout A, Aldeeb YM, Alfouzan W, Almaslamani MA; SOAB Study Group
Clin Microbiol Infect 2024 Apr;30(4):492-498. Epub 2023 Oct 18 doi: 10.1016/j.cmi.2023.10.014. PMID: 37858867
Update on Staphylococcus aureus bacteraemia.
Tabah A, Laupland KB
Curr Opin Crit Care 2022 Oct 1;28(5):495-504. Epub 2022 Aug 4 doi: 10.1097/MCC.0000000000000974. PMID: 35942696
Performance of the Reveal Rapid Antibiotic Susceptibility Testing System on Gram-Negative Blood Cultures at a Large Urban Hospital.
Tibbetts R, George S, Burwell R, Rajeev L, Rhodes PA, Singh P, Samuel L
J Clin Microbiol 2022 Jun 15;60(6):e0009822. Epub 2022 May 24 doi: 10.1128/jcm.00098-22. PMID: 35607972Free PMC Article
Bloodstream infections in critically ill patients: an expert statement.
Timsit JF, Ruppé E, Barbier F, Tabah A, Bassetti M
Intensive Care Med 2020 Feb;46(2):266-284. Epub 2020 Feb 11 doi: 10.1007/s00134-020-05950-6. PMID: 32047941Free PMC Article

Prognosis

Molecular rapid diagnostic testing for bloodstream infections: Nanopore targeted sequencing with pathogen-specific primers.
Han D, Yu F, Zhang D, Hu J, Zhang X, Xiang D, Lou B, Chen Y, Zheng S
J Infect 2024 Jun;88(6):106166. Epub 2024 Apr 24 doi: 10.1016/j.jinf.2024.106166. PMID: 38670268
Comparing the Prognosis of Patient with Alcohol and Nonalcohol-Associated Cirrhosis with Bacteremia.
Huang HK, Chen HY, Hsu YC
Alcohol Alcohol 2020 Aug 14;55(5):512-517. doi: 10.1093/alcalc/agaa057. PMID: 32599621
The presence of a single MALDI-TOF mass spectral peak predicts methicillin resistance in staphylococci.
Rhoads DD, Wang H, Karichu J, Richter SS
Diagn Microbiol Infect Dis 2016 Nov;86(3):257-261. Epub 2016 Aug 7 doi: 10.1016/j.diagmicrobio.2016.08.001. PMID: 27568365
Rapidly growing mycobacterial bloodstream infections.
El Helou G, Viola GM, Hachem R, Han XY, Raad II
Lancet Infect Dis 2013 Feb;13(2):166-74. doi: 10.1016/S1473-3099(12)70316-X. PMID: 23347634
Neonatal septicaemia in Calabar, Nigeria.
Anah MU, Udo JJ, Ochigbo SO, Abia-Bassey LN
Trop Doct 2008 Apr;38(2):126-8. doi: 10.1258/td.2006.006037. PMID: 18453516

Clinical prediction guides

Carbapenem combination therapy versus standard of care for persistent methicillin-susceptible Staphylococcus aureus bacteraemia.
Shah S, Clarke LG, Ludwig J, Burgdorf S, Arbulu Guerra RD, Shields RK
J Antimicrob Chemother 2024 Aug 1;79(8):1990-1997. doi: 10.1093/jac/dkae198. PMID: 38946294
Molecular rapid diagnostic testing for bloodstream infections: Nanopore targeted sequencing with pathogen-specific primers.
Han D, Yu F, Zhang D, Hu J, Zhang X, Xiang D, Lou B, Chen Y, Zheng S
J Infect 2024 Jun;88(6):106166. Epub 2024 Apr 24 doi: 10.1016/j.jinf.2024.106166. PMID: 38670268
Mortality in KPC-producing Klebsiella pneumoniae bloodstream infections: a changing landscape.
Giacobbe DR, Marelli C, Cattardico G, Fanelli C, Signori A, Di Meco G, Di Pilato V, Mikulska M, Mazzitelli M, Cattelan AM, Pallotto C, Francisci D, Calabresi A, Lombardi A, Gori A, Del Bono V, Aldieri C, Losito AR, Raffaelli F, Cortegiani A, Milazzo M, Del Puente F, Pontali E, De Rosa FG, Corcione S, Mularoni A, Russelli G, Giacomini M, Badalucco Ciotta F, Oltolini C, Serino FS, Momesso E, Spinicci M, Graziani L, Torti C, Trecarichi EM, Merli M, D'Amico F, Marchese A, Vena A, Bassetti M
J Antimicrob Chemother 2023 Oct 3;78(10):2505-2514. doi: 10.1093/jac/dkad262. PMID: 37606528
Comparison of the Treatment Outcome of Piperacillin-Tazobactam versus Carbapenems for Patients with Bacteremia Caused by Extended-Spectrum β-Lactamase-Producing Escherichia coli in Areas with Low Frequency of Coproduction of OXA-1: a Preliminary Analysis.
Hoashi K, Hayama B, Suzuki M, Sakurai A, Takehana K, Enokida T, Takeda K, Ohkushi D, Doi Y, Harada S
Microbiol Spectr 2022 Aug 31;10(4):e0220622. Epub 2022 Aug 2 doi: 10.1128/spectrum.02206-22. PMID: 35916524Free PMC Article
Bloodstream infections in critically ill patients: an expert statement.
Timsit JF, Ruppé E, Barbier F, Tabah A, Bassetti M
Intensive Care Med 2020 Feb;46(2):266-284. Epub 2020 Feb 11 doi: 10.1007/s00134-020-05950-6. PMID: 32047941Free PMC Article

Recent systematic reviews

A systematic review on the excess health risk of antibiotic-resistant bloodstream infections for six key pathogens in Europe.
Hassoun-Kheir N, Guedes M, Ngo Nsoga MT, Argante L, Arieti F, Gladstone BP, Kingston R, Naylor NR, Pezzani MD, Pouwels KB, Robotham JV, Rodríguez-Baño J, Tacconelli E, Vella V, Harbarth S, de Kraker MEA; PrIMAVeRa Workpackage 1
Clin Microbiol Infect 2024 Mar;30 Suppl 1:S14-S25. Epub 2023 Oct 4 doi: 10.1016/j.cmi.2023.09.001. PMID: 37802750
A Systematic Review and Meta-analysis of the Prevalence of Community-Onset Bloodstream Infections among Hospitalized Patients in Africa and Asia.
Marchello CS, Dale AP, Pisharody S, Rubach MP, Crump JA
Antimicrob Agents Chemother 2019 Dec 20;64(1) doi: 10.1128/AAC.01974-19. PMID: 31636071Free PMC Article
A systematic review of the association between delayed appropriate therapy and mortality among patients hospitalized with infections due to Klebsiella pneumoniae or Escherichia coli: how long is too long?
Lodise TP, Zhao Q, Fahrbach K, Gillard PJ, Martin A
BMC Infect Dis 2018 Dec 5;18(1):625. doi: 10.1186/s12879-018-3524-8. PMID: 30518337Free PMC Article
Antibiotic de-escalation for bloodstream infections and pneumonia: systematic review and meta-analysis.
Paul M, Dickstein Y, Raz-Pasteur A
Clin Microbiol Infect 2016 Dec;22(12):960-967. Epub 2016 Jun 6 doi: 10.1016/j.cmi.2016.05.023. PMID: 27283148
Probiotics for preventing urinary tract infections in adults and children.
Schwenger EM, Tejani AM, Loewen PS
Cochrane Database Syst Rev 2015 Dec 23;2015(12):CD008772. doi: 10.1002/14651858.CD008772.pub2. PMID: 26695595Free PMC Article

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