U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ovarian cancer, susceptibility to, 1(OVCAS1)

MedGen UID:
390836
Concept ID:
C2675601
Finding
Synonyms: Ovarian cancer 1; OVCAS1
 
Monarch Initiative: MONDO:0011931
OMIM®: 607893

Professional guidelines

PubMed

Daly MB, Pal T, Maxwell KN, Churpek J, Kohlmann W, AlHilli Z, Arun B, Buys SS, Cheng H, Domchek SM, Friedman S, Giri V, Goggins M, Hagemann A, Hendrix A, Hutton ML, Karlan BY, Kassem N, Khan S, Khoury K, Kurian AW, Laronga C, Mak JS, Mansour J, McDonnell K, Menendez CS, Merajver SD, Norquist BS, Offit K, Rash D, Reiser G, Senter-Jamieson L, Shannon KM, Visvanathan K, Welborn J, Wick MJ, Wood M, Yurgelun MB, Dwyer MA, Darlow SD
J Natl Compr Canc Netw 2023 Oct;21(10):1000-1010. doi: 10.6004/jnccn.2023.0051. PMID: 37856201
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML; CGC, Karlan BY, Khan S, Klein C, Kohlmann W; CGC, Kurian AW, Laronga C, Litton JK, Mak JS; LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G; CGC, Senter-Jamieson L; CGC, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA
J Natl Compr Canc Netw 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001. PMID: 33406487
Yoshida R
Breast Cancer 2021 Nov;28(6):1167-1180. Epub 2020 Aug 29 doi: 10.1007/s12282-020-01148-2. PMID: 32862296Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer, 2024

UK NICE Clinical guideline (CG122), Ovarian cancer: recognition and initial management, 2023

Recent clinical studies

Etiology

Steinbuch SC, Lüß AM, Eltrop S, Götte M, Kiesel L
Int J Mol Sci 2024 Apr 13;25(8) doi: 10.3390/ijms25084306. PMID: 38673891Free PMC Article
Daly MB, Pal T, Maxwell KN, Churpek J, Kohlmann W, AlHilli Z, Arun B, Buys SS, Cheng H, Domchek SM, Friedman S, Giri V, Goggins M, Hagemann A, Hendrix A, Hutton ML, Karlan BY, Kassem N, Khan S, Khoury K, Kurian AW, Laronga C, Mak JS, Mansour J, McDonnell K, Menendez CS, Merajver SD, Norquist BS, Offit K, Rash D, Reiser G, Senter-Jamieson L, Shannon KM, Visvanathan K, Welborn J, Wick MJ, Wood M, Yurgelun MB, Dwyer MA, Darlow SD
J Natl Compr Canc Netw 2023 Oct;21(10):1000-1010. doi: 10.6004/jnccn.2023.0051. PMID: 37856201
Sessa C, Balmaña J, Bober SL, Cardoso MJ, Colombo N, Curigliano G, Domchek SM, Evans DG, Fischerova D, Harbeck N, Kuhl C, Lemley B, Levy-Lahad E, Lambertini M, Ledermann JA, Loibl S, Phillips KA, Paluch-Shimon S; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Jan;34(1):33-47. Epub 2022 Oct 25 doi: 10.1016/j.annonc.2022.10.004. PMID: 36307055
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Varol U, Kucukzeybek Y, Alacacioglu A, Somali I, Altun Z, Aktas S, Oktay Tarhan M
J BUON 2018 Jul-Aug;23(4):862-866. PMID: 30358186

Diagnosis

Wang Y, Hu M, Cao J, Wang F, Han JR, Wu TW, Li L, Yu J, Fan Y, Xie G, Lian H, Cao Y, Naowarojna N, Wang X, Zou Y
Cell 2025 Jan 23;188(2):412-429.e27. Epub 2024 Nov 25 doi: 10.1016/j.cell.2024.10.047. PMID: 39591965
Daly MB, Pal T, Maxwell KN, Churpek J, Kohlmann W, AlHilli Z, Arun B, Buys SS, Cheng H, Domchek SM, Friedman S, Giri V, Goggins M, Hagemann A, Hendrix A, Hutton ML, Karlan BY, Kassem N, Khan S, Khoury K, Kurian AW, Laronga C, Mak JS, Mansour J, McDonnell K, Menendez CS, Merajver SD, Norquist BS, Offit K, Rash D, Reiser G, Senter-Jamieson L, Shannon KM, Visvanathan K, Welborn J, Wick MJ, Wood M, Yurgelun MB, Dwyer MA, Darlow SD
J Natl Compr Canc Netw 2023 Oct;21(10):1000-1010. doi: 10.6004/jnccn.2023.0051. PMID: 37856201
Sessa C, Balmaña J, Bober SL, Cardoso MJ, Colombo N, Curigliano G, Domchek SM, Evans DG, Fischerova D, Harbeck N, Kuhl C, Lemley B, Levy-Lahad E, Lambertini M, Ledermann JA, Loibl S, Phillips KA, Paluch-Shimon S; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Jan;34(1):33-47. Epub 2022 Oct 25 doi: 10.1016/j.annonc.2022.10.004. PMID: 36307055
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML; CGC, Karlan BY, Khan S, Klein C, Kohlmann W; CGC, Kurian AW, Laronga C, Litton JK, Mak JS; LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G; CGC, Senter-Jamieson L; CGC, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA
J Natl Compr Canc Netw 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001. PMID: 33406487

Therapy

Wang H, Reid BM, Richmond RC, Lane JM, Saxena R, Gonzalez BD, Fridley BL, Redline S, Tworoger SS, Wang X
EBioMedicine 2024 Jun;104:105175. Epub 2024 Jun 1 doi: 10.1016/j.ebiom.2024.105175. PMID: 38823087Free PMC Article
Wu Y, Xu S, Cheng S, Yang J, Wang Y
J Ovarian Res 2023 Jan 7;16(1):6. doi: 10.1186/s13048-023-01094-5. PMID: 36611214Free PMC Article
Hart SN, Hoskin T, Shimelis H, Moore RM, Feng B, Thomas A, Lindor NM, Polley EC, Goldgar DE, Iversen E, Monteiro ANA, Suman VJ, Couch FJ
Genet Med 2019 Jan;21(1):71-80. Epub 2018 Jun 8 doi: 10.1038/s41436-018-0018-4. PMID: 29884841Free PMC Article
Brown JS, O'Carrigan B, Jackson SP, Yap TA
Cancer Discov 2017 Jan;7(1):20-37. Epub 2016 Dec 21 doi: 10.1158/2159-8290.CD-16-0860. PMID: 28003236Free PMC Article
Goulooze SC, Cohen AF, Rissmann R
Br J Clin Pharmacol 2016 Jan;81(1):171-3. Epub 2015 Oct 24 doi: 10.1111/bcp.12761. PMID: 26344419Free PMC Article

Prognosis

Wang H, Reid BM, Richmond RC, Lane JM, Saxena R, Gonzalez BD, Fridley BL, Redline S, Tworoger SS, Wang X
EBioMedicine 2024 Jun;104:105175. Epub 2024 Jun 1 doi: 10.1016/j.ebiom.2024.105175. PMID: 38823087Free PMC Article
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Yoshida R
Breast Cancer 2021 Nov;28(6):1167-1180. Epub 2020 Aug 29 doi: 10.1007/s12282-020-01148-2. PMID: 32862296Free PMC Article
Hart SN, Hoskin T, Shimelis H, Moore RM, Feng B, Thomas A, Lindor NM, Polley EC, Goldgar DE, Iversen E, Monteiro ANA, Suman VJ, Couch FJ
Genet Med 2019 Jan;21(1):71-80. Epub 2018 Jun 8 doi: 10.1038/s41436-018-0018-4. PMID: 29884841Free PMC Article
Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W
Science 1994 Oct 7;266(5182):66-71. doi: 10.1126/science.7545954. PMID: 7545954

Clinical prediction guides

Wang H, Reid BM, Richmond RC, Lane JM, Saxena R, Gonzalez BD, Fridley BL, Redline S, Tworoger SS, Wang X
EBioMedicine 2024 Jun;104:105175. Epub 2024 Jun 1 doi: 10.1016/j.ebiom.2024.105175. PMID: 38823087Free PMC Article
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Hart SN, Hoskin T, Shimelis H, Moore RM, Feng B, Thomas A, Lindor NM, Polley EC, Goldgar DE, Iversen E, Monteiro ANA, Suman VJ, Couch FJ
Genet Med 2019 Jan;21(1):71-80. Epub 2018 Jun 8 doi: 10.1038/s41436-018-0018-4. PMID: 29884841Free PMC Article
Ramus SJ, Song H, Dicks E, Tyrer JP, Rosenthal AN, Intermaggio MP, Fraser L, Gentry-Maharaj A, Hayward J, Philpott S, Anderson C, Edlund CK, Conti D, Harrington P, Barrowdale D, Bowtell DD, Alsop K, Mitchell G; AOCS Study Group, Cicek MS, Cunningham JM, Fridley BL, Alsop J, Jimenez-Linan M, Poblete S, Lele S, Sucheston-Campbell L, Moysich KB, Sieh W, McGuire V, Lester J, Bogdanova N, Dürst M, Hillemanns P; Ovarian Cancer Association Consortium, Odunsi K, Whittemore AS, Karlan BY, Dörk T, Goode EL, Menon U, Jacobs IJ, Antoniou AC, Pharoah PD, Gayther SA
J Natl Cancer Inst 2015 Nov;107(11) Epub 2015 Aug 27 doi: 10.1093/jnci/djv214. PMID: 26315354Free PMC Article
Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W
Science 1994 Oct 7;266(5182):66-71. doi: 10.1126/science.7545954. PMID: 7545954

Recent systematic reviews

Mei J, Qian M, Hou Y, Liang M, Chen Y, Wang C, Zhang J
Lipids Health Dis 2024 Jan 30;23(1):32. doi: 10.1186/s12944-024-02025-z. PMID: 38291432Free PMC Article
van Bommel MHD, IntHout J, Veldmate G, Kets CM, de Hullu JA, van Altena AM, Harmsen MG
Hum Reprod Update 2023 Mar 1;29(2):197-217. doi: 10.1093/humupd/dmac038. PMID: 36383189Free PMC Article
Lau CH, Seow KM, Chen KH
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158125. PMID: 35897700Free PMC Article
Tattersall A, Ryan N, Wiggans AJ, Rogozińska E, Morrison J
Cochrane Database Syst Rev 2022 Feb 16;2(2):CD007929. doi: 10.1002/14651858.CD007929.pub4. PMID: 35170751Free PMC Article
Tanha K, Mottaghi A, Nojomi M, Moradi M, Rajabzadeh R, Lotfi S, Janani L
J Ovarian Res 2021 Nov 11;14(1):153. doi: 10.1186/s13048-021-00911-z. PMID: 34758846Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer, 2024
    • NICE, 2023
      UK NICE Clinical guideline (CG122), Ovarian cancer: recognition and initial management, 2023

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...