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Bilateral cleft lip and palate

MedGen UID:
853256
•Concept ID:
C1398522
•
Congenital Abnormality
Synonym: Bilateral cleft lip/palate
SNOMED CT: Cleft palate and bilateral cleft lip (1085331000119107); Uranostaphyloschisis with bilateral cleft lip (1085331000119107); Cleft hard and soft palate and bilateral cleft lip (1085331000119107)

Professional guidelines

PubMed

Long-term treatment outcome of patients with complete bilateral cleft lip and palate: a retrospective cohort study.
Hattori Y, Pai BC, Saito T, Chou PY, Lu TC, Chang CS, Chen YR, Lo LJ
Int J Surg 2023 Jun 1;109(6):1656-1667. doi: 10.1097/JS9.0000000000000406. PMID: 37073546Free PMC Article
Primary Palatal Surgery in Nonsyndromic Cleft Palate Children and Velopharyngeal Insufficiency Correction Outcomes.
Carvajal Álvarez DC, Palomares-Aguilera MM, Meneses Geldres MB, Villarroel Giugliano C
J Craniofac Surg 2021 Mar-Apr 01;32(2):698-704. doi: 10.1097/SCS.0000000000007514. PMID: 33705013
Management of the protuberant premaxilla: where does it fit in?
Morris L
Curr Opin Otolaryngol Head Neck Surg 2019 Aug;27(4):302-309. doi: 10.1097/MOO.0000000000000558. PMID: 31219831

Recent clinical studies

Etiology

Premaxillary Setback in Bilateral Cleft Lip and Palate Repair.
Stanton E, Kondra K, Jimenez C, Shakoori P, Yen S, Urata MM, Hammoudeh JA, Magee WP 3rd
Cleft Palate Craniofac J 2024 Mar;61(3):416-421. Epub 2022 Nov 29 doi: 10.1177/10556656221130166. PMID: 36448087
Surgical-orthodontic treatment for severe malocclusion in a patient with osteopetrosis and bilateral cleft lip and palate.
Kim JK, Kim JY, Jung HD, Jung YS
Angle Orthod 2021 Jul 1;91(4):555-563. doi: 10.2319/080320-678.1. PMID: 34181720Free PMC Article
Alveolar bone grafting and gingivoperiosteoplasty in bilateral cleft lip and palate.
Chhajlani R, Chhajlani P, Bonanthaya K, Mahajan RK
Curr Opin Otolaryngol Head Neck Surg 2021 Aug 1;29(4):327-332. doi: 10.1097/MOO.0000000000000737. PMID: 34091502
Three-Dimensional Analysis of Bilateral Cleft Lip and Palate Nasal Deformity.
Harrison LM, Hallac RR, Derderian CA
Cleft Palate Craniofac J 2021 Jan;58(1):105-113. Epub 2020 Jul 21 doi: 10.1177/1055665620940190. PMID: 32691613
Longitudinal study of the dental arch dimensions in bilateral cleft lip and palate patients.
Athanasiou AE, Maaheri M, Zarrinnia K
J Pedod 1987 Spring;11(3):253-68. PMID: 3473214

Diagnosis

Bilateral cleft lip, alveolus, and palate deformity in an infant.
Nimonkar SV, Belkhode VM
Pan Afr Med J 2022;42:316. Epub 2022 Aug 29 doi: 10.11604/pamj.2022.42.316.33040. PMID: 36451981Free PMC Article
Surgical-orthodontic treatment for severe malocclusion in a patient with osteopetrosis and bilateral cleft lip and palate.
Kim JK, Kim JY, Jung HD, Jung YS
Angle Orthod 2021 Jul 1;91(4):555-563. doi: 10.2319/080320-678.1. PMID: 34181720Free PMC Article
Invasive cervical resorption and the oro-facial cleft patient: a review and case series.
O'Mahony A, McNamara C, Ireland A, Sandy J, Puryer J
Br Dent J 2017 May 12;222(9):677-681. doi: 10.1038/sj.bdj.2017.405. PMID: 28496230
Indices to assess malocclusions in patients with cleft lip and palate.
Altalibi M, Saltaji H, Edwards R, Major PW, Flores-Mir C
Eur J Orthod 2013 Dec;35(6):772-82. Epub 2013 Mar 15 doi: 10.1093/ejo/cjt009. PMID: 23504529
Omphalocele, bladder exstrophy, imperforate anus, spine defects complex, and bilateral cleft lip and palate in one product of a triplet pregnancy obtained by in vitro fertilization: a case report.
Yokoyama E, Del Castillo V, Ramos S, Angel AG
Am J Med Genet A 2007 Aug 15;143A(16):1933-5. doi: 10.1002/ajmg.a.31828. PMID: 17632776

Therapy

Treatment Outcome in Bilateral Cleft lip and Palate Patients Evaluated With the Huddart-Bodenham Scoring System and the Bilateral Cleft lip and Palate Yardstick: A Systematic Review.
Kuang W, Aarts M, Kuijpers-Jagtman AM, He H, Ongkosuwito EM
Cleft Palate Craniofac J 2022 Nov;59(11):1377-1390. Epub 2021 Oct 18 doi: 10.1177/10556656211041883. PMID: 34658258Free PMC Article
Bilateral Cleft Lip and Palate, With Facial Dysplasia: Interdisciplinary Treatment and Long-Term Follow-Up.
Bennun RD, Harfin JH
J Craniofac Surg 2018 Sep;29(6):1441-1444. doi: 10.1097/SCS.0000000000004756. PMID: 30015740
Invasive cervical resorption and the oro-facial cleft patient: a review and case series.
O'Mahony A, McNamara C, Ireland A, Sandy J, Puryer J
Br Dent J 2017 May 12;222(9):677-681. doi: 10.1038/sj.bdj.2017.405. PMID: 28496230
Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate.
Guo J, Li C, Zhang Q, Wu G, Deacon SA, Chen J, Hu H, Zou S, Ye Q
Cochrane Database Syst Rev 2011 Jun 15;(6):CD008050. doi: 10.1002/14651858.CD008050.pub2. PMID: 21678372
Omphalocele, bladder exstrophy, imperforate anus, spine defects complex, and bilateral cleft lip and palate in one product of a triplet pregnancy obtained by in vitro fertilization: a case report.
Yokoyama E, Del Castillo V, Ramos S, Angel AG
Am J Med Genet A 2007 Aug 15;143A(16):1933-5. doi: 10.1002/ajmg.a.31828. PMID: 17632776

Prognosis

Long-term Follow-up of Bilateral Cleft Lip and Palate: Incidence of Speech-Correcting Surgeries and Fistula Formation.
Gustafsson C, Heliövaara A, Rautio J, Leikola J
Cleft Palate Craniofac J 2023 Oct;60(10):1241-1249. Epub 2022 Jun 20 doi: 10.1177/10556656221102816. PMID: 35726173Free PMC Article
Three-Dimensional Analysis of Bilateral Cleft Lip and Palate Nasal Deformity.
Harrison LM, Hallac RR, Derderian CA
Cleft Palate Craniofac J 2021 Jan;58(1):105-113. Epub 2020 Jul 21 doi: 10.1177/1055665620940190. PMID: 32691613
Cephalometric and morphologic facial changes in adults with complete bilateral cleft lip and palate.
Smahel Z
Acta Chir Plast 1984;26(4):200-15. PMID: 6084381
Longitudinal study of growth in bilateral cleft lip and palate, from infancy to adolescence.
Friede H, Pruzansky S
Plast Reconstr Surg 1972 Apr;49(4):392-403. doi: 10.1097/00006534-197204000-00005. PMID: 5014698
RECESSION OF THE PREMAXILLA IN BILATERAL CLEFT LIP AND PALATE; A FOLLOW-UP STUDY.
MONROE CW
Plast Reconstr Surg 1965 May;35:512-30. doi: 10.1097/00006534-196505000-00008. PMID: 14288731

Clinical prediction guides

Long-term Follow-up of Bilateral Cleft Lip and Palate: Incidence of Speech-Correcting Surgeries and Fistula Formation.
Gustafsson C, Heliövaara A, Rautio J, Leikola J
Cleft Palate Craniofac J 2023 Oct;60(10):1241-1249. Epub 2022 Jun 20 doi: 10.1177/10556656221102816. PMID: 35726173Free PMC Article
What is the Effectiveness of Premaxilla Surgical Repositioning and its Stabilization Methods in Mixed Dentition Patients With Bilateral Cleft Lip and Palate?
Normande Neto HV, Oliveira-Neto OB, Ribeiro ILH, Andrade CS, Sales PHDH, Lima FJC
Cleft Palate Craniofac J 2023 Oct;60(10):1211-1219. Epub 2022 May 9 doi: 10.1177/10556656221096304. PMID: 35535395
Treatment Outcome in Bilateral Cleft lip and Palate Patients Evaluated With the Huddart-Bodenham Scoring System and the Bilateral Cleft lip and Palate Yardstick: A Systematic Review.
Kuang W, Aarts M, Kuijpers-Jagtman AM, He H, Ongkosuwito EM
Cleft Palate Craniofac J 2022 Nov;59(11):1377-1390. Epub 2021 Oct 18 doi: 10.1177/10556656211041883. PMID: 34658258Free PMC Article
Malocclusion in complete unilateral and bilateral cleft lip and palate. The results of a change in the surgical procedure.
Mølsted K, Palmberg A, Dahl E, Fogh-Andersen P
Scand J Plast Reconstr Surg Hand Surg 1987;21(1):81-5. doi: 10.3109/02844318709083584. PMID: 3589584
The changes produced by presurgical orthopedic treatment of bilateral cleft lip and palate.
Robertson N, Shaw W, Volp C
Plast Reconstr Surg 1977 Jan;59(1):87-93. PMID: 831244

Recent systematic reviews

A systematic review of differences in outcome between one and two stage palate repair in cleft lip and palate.
Cornefjord M, Arnebrant K, Guné H, Holst J, Klintö K, Stiernman M, Svensson H, Wiedel AP, Becker M
J Plast Surg Hand Surg 2023 Dec 14;58:132-141. doi: 10.2340/jphs.v58.13368. PMID: 38095226
What is the Effectiveness of Premaxilla Surgical Repositioning and its Stabilization Methods in Mixed Dentition Patients With Bilateral Cleft Lip and Palate?
Normande Neto HV, Oliveira-Neto OB, Ribeiro ILH, Andrade CS, Sales PHDH, Lima FJC
Cleft Palate Craniofac J 2023 Oct;60(10):1211-1219. Epub 2022 May 9 doi: 10.1177/10556656221096304. PMID: 35535395
Cranial Base Angle in Patients With Cleft Lip and Palate-A Systematic Review and Meta-Analysis.
Murugan C, Kailasam V
Cleft Palate Craniofac J 2023 Jan;60(1):39-54. Epub 2021 Nov 17 doi: 10.1177/10556656211053545. PMID: 34787478
Treatment Outcome in Bilateral Cleft lip and Palate Patients Evaluated With the Huddart-Bodenham Scoring System and the Bilateral Cleft lip and Palate Yardstick: A Systematic Review.
Kuang W, Aarts M, Kuijpers-Jagtman AM, He H, Ongkosuwito EM
Cleft Palate Craniofac J 2022 Nov;59(11):1377-1390. Epub 2021 Oct 18 doi: 10.1177/10556656211041883. PMID: 34658258Free PMC Article
Repair Sequence and Management of the Premaxilla in Patients With Bilateral Cleft Lip and Palate: A Systematic Review of the Literature.
Chang IA, Bassiri Gharb B, Papay FA, Rampazzo A
J Craniofac Surg 2022 Mar-Apr 01;33(2):421-425. doi: 10.1097/SCS.0000000000008184. PMID: 34560740

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