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Hemangiomatosis

MedGen UID:
278015
•Concept ID:
C1384590
•
Neoplastic Process
SNOMED CT: Hemangiomatosis (254785001); Hemangiomatosis (47669001)
 
HPO: HP:0007461

Professional guidelines

PubMed

Use of vasodilators for the treatment of pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis: A systematic review.
Ogawa A, Sakao S, Tanabe N, Matsubara H, Tatsumi K
Respir Investig 2019 Mar;57(2):183-190. Epub 2018 Nov 23 doi: 10.1016/j.resinv.2018.10.004. PMID: 30473253
International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.
Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS
Blood 2017 Mar 23;129(12):1646-1657. Epub 2017 Jan 13 doi: 10.1182/blood-2016-10-746933. PMID: 28087540Free PMC Article
Multimodal management of diffuse neonatal hemangiomatosis.
Blei F, Orlow SJ, Geronemus R
J Am Acad Dermatol 1997 Dec;37(6):1019-21. doi: 10.1016/s0190-9622(97)70097-5. PMID: 9418785

Recent clinical studies

Etiology

Benign Neonatal Hemangiomatosis.
Miller AC, Gordon ES, Peterson CR, Cohen DJ, Bowe AC
Adv Neonatal Care 2022 Oct 1;22(5):408-412. Epub 2022 Mar 29 doi: 10.1097/ANC.0000000000000982. PMID: 35749711
Hemangioma-related syndromes.
Valdebran M, Wine Lee L
Curr Opin Pediatr 2020 Aug;32(4):498-505. doi: 10.1097/MOP.0000000000000925. PMID: 32692048
Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis.
Ortiz-Bautista C, Hernández-González I, Escribano-Subías P
Med Clin (Barc) 2017 Mar 22;148(6):265-270. Epub 2017 Jan 22 doi: 10.1016/j.medcli.2016.11.031. PMID: 28118962
International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.
Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS
Blood 2017 Mar 23;129(12):1646-1657. Epub 2017 Jan 13 doi: 10.1182/blood-2016-10-746933. PMID: 28087540Free PMC Article
Updated clinical classification of pulmonary hypertension.
Simonneau G, Robbins IM, Beghetti M, Channick RN, Delcroix M, Denton CP, Elliott CG, Gaine SP, Gladwin MT, Jing ZC, Krowka MJ, Langleben D, Nakanishi N, Souza R
J Am Coll Cardiol 2009 Jun 30;54(1 Suppl):S43-S54. doi: 10.1016/j.jacc.2009.04.012. PMID: 19555858

Diagnosis

Hemangioma-related syndromes.
Valdebran M, Wine Lee L
Curr Opin Pediatr 2020 Aug;32(4):498-505. doi: 10.1097/MOP.0000000000000925. PMID: 32692048
Genetics of Pulmonary Arterial Hypertension.
Chew JD, Loyd JE, Austin ED
Semin Respir Crit Care Med 2017 Oct;38(5):585-595. Epub 2017 Oct 15 doi: 10.1055/s-0037-1606201. PMID: 29032562Free PMC Article
International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.
Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS
Blood 2017 Mar 23;129(12):1646-1657. Epub 2017 Jan 13 doi: 10.1182/blood-2016-10-746933. PMID: 28087540Free PMC Article
Multifocal vascular lesions.
Levin LE, Lauren CT
Semin Cutan Med Surg 2016 Sep;35(3):153-60. doi: 10.12788/j.sder.2016.054. PMID: 27607324
Choroidal hemangioma.
Singh AD, Kaiser PK, Sears JE
Ophthalmol Clin North Am 2005 Mar;18(1):151-61, ix. doi: 10.1016/j.ohc.2004.07.004. PMID: 15763200

Therapy

Updated clinical classification of pulmonary hypertension.
Simonneau G, Robbins IM, Beghetti M, Channick RN, Delcroix M, Denton CP, Elliott CG, Gaine SP, Gladwin MT, Jing ZC, Krowka MJ, Langleben D, Nakanishi N, Souza R
J Am Coll Cardiol 2009 Jun 30;54(1 Suppl):S43-S54. doi: 10.1016/j.jacc.2009.04.012. PMID: 19555858
Successful treatment with cyclophosphamide of life-threatening diffuse hemangiomatosis involving the liver.
Hurvitz SA, Hurvitz CH, Sloninsky L, Sanford MC
J Pediatr Hematol Oncol 2000 Nov-Dec;22(6):527-32. doi: 10.1097/00043426-200011000-00012. PMID: 11132222
Multimodal management of diffuse neonatal hemangiomatosis.
Stratte EG, Tope WD, Johnson CL, Swanson NA
J Am Acad Dermatol 1996 Feb;34(2 Pt 2):337-42. doi: 10.1016/s0190-9622(07)80004-1. PMID: 8655722
Diffuse neonatal hemangiomatosis.
Golitz LE, Rudikoff J, O'Meara OP
Pediatr Dermatol 1986 Feb;3(2):145-52. doi: 10.1111/j.1525-1470.1986.tb00506.x. PMID: 3952031
Diffuse neonatal hemangiomatosis.
Holden KR, Alexander F
Pediatrics 1970 Sep;46(3):411-21. PMID: 5465931

Prognosis

Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis.
Shi W, Jiao Y
QJM 2020 May 1;113(5):371-372. doi: 10.1093/qjmed/hcz233. PMID: 31501875
Multiple hemangiomas and hemangiomatosis--risk factors and outcome over an eight year period.
Schupp CJ, Holland-Cunz S, Schenk JP, Weisser H, Grimm D, Günther P
Eur J Pediatr Surg 2010 Nov;20(6):379-81. Epub 2010 Jul 27 doi: 10.1055/s-0030-1261938. PMID: 20665431
Updated clinical classification of pulmonary hypertension.
Simonneau G, Robbins IM, Beghetti M, Channick RN, Delcroix M, Denton CP, Elliott CG, Gaine SP, Gladwin MT, Jing ZC, Krowka MJ, Langleben D, Nakanishi N, Souza R
J Am Coll Cardiol 2009 Jun 30;54(1 Suppl):S43-S54. doi: 10.1016/j.jacc.2009.04.012. PMID: 19555858
Choroidal hemangioma.
Singh AD, Kaiser PK, Sears JE
Ophthalmol Clin North Am 2005 Mar;18(1):151-61, ix. doi: 10.1016/j.ohc.2004.07.004. PMID: 15763200
Tumors of the pulmonary vasculature.
Yi ES
Cardiol Clin 2004 Aug;22(3):431-40, vi-vii. doi: 10.1016/j.ccl.2004.05.001. PMID: 15302362

Clinical prediction guides

Benign Neonatal Hemangiomatosis.
Miller AC, Gordon ES, Peterson CR, Cohen DJ, Bowe AC
Adv Neonatal Care 2022 Oct 1;22(5):408-412. Epub 2022 Mar 29 doi: 10.1097/ANC.0000000000000982. PMID: 35749711
Living-donor liver transplantation for giant hepatic hemangioma with diffuse hemangiomatosis in an adult: a case report.
Lee JH, Yoon CJ, Kim YH, Han HS, Cho JY, Kim H, Jang ES, Kim JW, Jeong SH
Clin Mol Hepatol 2018 Jun;24(2):163-168. Epub 2017 Jul 19 doi: 10.3350/cmh.2017.0002. PMID: 28719965Free PMC Article
A peculiar case of diffuse hemangiomatosis of the left hepatic lobe in an asymptomatic adult patient: case report and literature review.
Guerra A, Infante A, Rinninella E, Spinelli I, Mazziotti MA, De Gaetano AM, Pompili M, Bonomo L
Eur Rev Med Pharmacol Sci 2017 Apr;21(7):1593-1597. PMID: 28429345
Imatinib is partially effective for the treatment of pulmonary capillary hemangiomatosis.
Adachi S, Hirashiki A, Kondo T, Nakaguro M, Ogawa A, Miyaji K, Matsubara H, Yokoi T, Murohara T
Intern Med 2014;53(6):603-7. doi: 10.2169/internalmedicine.53.1157. PMID: 24633031
Diffuse pulmonary hemangiomatosis.
Rowen M, Thompson JR, Williamson RA, Wood BJ
Radiology 1978 May;127(2):445-51. doi: 10.1148/127.2.445. PMID: 644070

Recent systematic reviews

Use of vasodilators for the treatment of pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis: A systematic review.
Ogawa A, Sakao S, Tanabe N, Matsubara H, Tatsumi K
Respir Investig 2019 Mar;57(2):183-190. Epub 2018 Nov 23 doi: 10.1016/j.resinv.2018.10.004. PMID: 30473253
Endothelin receptor antagonists for pulmonary arterial hypertension.
Liu C, Chen J
Cochrane Database Syst Rev 2006 Jul 19;(3):CD004434. doi: 10.1002/14651858.CD004434.pub3. PMID: 16856046

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