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Lipedema

MedGen UID:
451048
Concept ID:
C0398370
Disease or Syndrome
Synonyms: Lipedemas; Lipoedema; Lipoedemas
SNOMED CT: Lipedema (234102003)
 
HPO: HP:0100695
Monarch Initiative: MONDO:0013577
OMIM®: 614103

Definition

Excess deposit and expansion of adipose tissue in an unusual pattern which cannot be lost through diet and exercise . [from HPO]

Clinical features

From HPO
Lipedema
MedGen UID:
451048
Concept ID:
C0398370
Disease or Syndrome
Excess deposit and expansion of adipose tissue in an unusual pattern which cannot be lost through diet and exercise .
Edema
MedGen UID:
4451
Concept ID:
C0013604
Pathologic Function
An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.
  • Abnormality of metabolism/homeostasis
  • Abnormality of the musculoskeletal system

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLipedema
Follow this link to review classifications for Lipedema in Orphanet.

Conditions with this feature

Lipedema
MedGen UID:
451048
Concept ID:
C0398370
Disease or Syndrome
Excess deposit and expansion of adipose tissue in an unusual pattern which cannot be lost through diet and exercise .

Professional guidelines

PubMed

Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Aksoy H, Karadag AS, Wollina U
Dermatol Ther 2021 Jan;34(1):e14364. Epub 2020 Oct 12 doi: 10.1111/dth.14364. PMID: 33001552
Kruppa P, Georgiou I, Biermann N, Prantl L, Klein-Weigel P, Ghods M
Dtsch Arztebl Int 2020 Jun 1;117(22-23):396-403. doi: 10.3238/arztebl.2020.0396. PMID: 32762835Free PMC Article

Recent clinical studies

Etiology

Kiani AK, Pheby D, Henehan G, Brown R, Sieving P, Sykora P, Marks R, Falsini B, Capodicasa N, Miertus S, Lorusso L, Dondossola D, Tartaglia GM, Ergoren MC, Dundar M, Michelini S, Malacarne D, Bonetti G, Dautaj A, Donato K, Medori MC, Beccari T, Samaja M, Connelly ST, Martin D, Morresi A, Bacu A, Herbst KL, Kapustin M, Stuppia L, Lumer L, Farronato G, Bertelli M; INTERNATIONAL BIOETHICS STUDY GROUP
J Prev Med Hyg 2022 Jun;63(2 Suppl 3):E255-E266. Epub 2022 Oct 17 doi: 10.15167/2421-4248/jpmh2022.63.2S3.2768. PMID: 36479489Free PMC Article
Dhuli K, Naureen Z, Medori MC, Fioretti F, Caruso P, Perrone MA, Nodari S, Manganotti P, Xhufi S, Bushati M, Bozo D, Connelly ST, Herbst KL, Bertelli M
J Prev Med Hyg 2022 Jun;63(2 Suppl 3):E150-E159. Epub 2022 Oct 17 doi: 10.15167/2421-4248/jpmh2022.63.2S3.2756. PMID: 36479484Free PMC Article
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Torre YS, Wadeea R, Rosas V, Herbst KL
Horm Mol Biol Clin Investig 2018 Mar 9;33(1) doi: 10.1515/hmbci-2017-0076. PMID: 29522416Free PMC Article
Canning C, Bartholomew JR
Vasc Med 2018 Feb;23(1):88-90. Epub 2017 Nov 16 doi: 10.1177/1358863X17739698. PMID: 29143577

Diagnosis

Lomeli LD, Makin V, Bartholomew JR, Burguera B
Cleve Clin J Med 2024 Jul 1;91(7):425-436. doi: 10.3949/ccjm.91a.23084. PMID: 38950986
Verde L, Camajani E, Annunziata G, Sojat A, Marina LV, Colao A, Caprio M, Muscogiuri G, Barrea L
Curr Obes Rep 2023 Dec;12(4):529-543. Epub 2023 Nov 4 doi: 10.1007/s13679-023-00536-x. PMID: 37924422Free PMC Article
Herbst KL, Kahn LA, Iker E, Ehrlich C, Wright T, McHutchison L, Schwartz J, Sleigh M, Donahue PM, Lisson KH, Faris T, Miller J, Lontok E, Schwartz MS, Dean SM, Bartholomew JR, Armour P, Correa-Perez M, Pennings N, Wallace EL, Larson E
Phlebology 2021 Dec;36(10):779-796. Epub 2021 May 28 doi: 10.1177/02683555211015887. PMID: 34049453Free PMC Article
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Kruppa P, Georgiou I, Biermann N, Prantl L, Klein-Weigel P, Ghods M
Dtsch Arztebl Int 2020 Jun 1;117(22-23):396-403. doi: 10.3238/arztebl.2020.0396. PMID: 32762835Free PMC Article

Therapy

Di Renzo L, Gualtieri P, Zomparelli S, De Santis GL, Seraceno S, Zuena C, Frank G, Cianci R, Centofanti D, De Lorenzo A
Nutrients 2023 Aug 20;15(16) doi: 10.3390/nu15163654. PMID: 37630844Free PMC Article
Podda M, Kovacs M, Hellmich M, Roth R, Zarrouk M, Kraus D, Prinz-Langenohl R, Cornely OA
Trials 2021 Oct 30;22(1):758. doi: 10.1186/s13063-021-05727-2. PMID: 34717741Free PMC Article
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Atan T, Bahar-Özdemir Y
Lymphat Res Biol 2021 Feb;19(1):86-95. Epub 2020 Dec 9 doi: 10.1089/lrb.2020.0019. PMID: 33297826
Shavit E, Wollina U, Alavi A
Int Wound J 2018 Dec;15(6):921-928. Epub 2018 Jun 29 doi: 10.1111/iwj.12949. PMID: 29956468Free PMC Article

Prognosis

Kempa S, Buechler C, Föh B, Felthaus O, Prantl L, Günther UL, Müller M, Derer-Petersen S, Sina C, Schmelter F, Tews HC
Int J Mol Sci 2023 Dec 13;24(24) doi: 10.3390/ijms242417437. PMID: 38139266Free PMC Article
Duhon BH, Phan TT, Taylor SL, Crescenzi RL, Rutkowski JM
Int J Mol Sci 2022 Jun 14;23(12) doi: 10.3390/ijms23126621. PMID: 35743063Free PMC Article
Wollina U, Koch A, Heinig B
Wien Med Wochenschr 2019 Feb;169(1-2):41-43. Epub 2018 Oct 22 doi: 10.1007/s10354-018-0666-7. PMID: 30349973
Reich-Schupke S, Schmeller W, Brauer WJ, Cornely ME, Faerber G, Ludwig M, Lulay G, Miller A, Rapprich S, Richter DF, Schacht V, Schrader K, Stücker M, Ure C
J Dtsch Dermatol Ges 2017 Jul;15(7):758-767. doi: 10.1111/ddg.13036. PMID: 28677175
Reich-Schupke S, Altmeyer P, Stücker M
J Dtsch Dermatol Ges 2013 Mar;11(3):225-33. Epub 2012 Dec 11 doi: 10.1111/ddg.12024. PMID: 23231593

Clinical prediction guides

Patton L, Ricolfi L, Bortolon M, Gabriele G, Zolesio P, Cione E, Cannataro R
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031599. PMID: 38338878Free PMC Article
Di Renzo L, Gualtieri P, Zomparelli S, De Santis GL, Seraceno S, Zuena C, Frank G, Cianci R, Centofanti D, De Lorenzo A
Nutrients 2023 Aug 20;15(16) doi: 10.3390/nu15163654. PMID: 37630844Free PMC Article
Kiani AK, Naureen Z, Pheby D, Henehan G, Brown R, Sieving P, Sykora P, Marks R, Falsini B, Capodicasa N, Miertus S, Lorusso L, Dondossola D, Tartaglia GM, Ergoren MC, Dundar M, Michelini S, Malacarne D, Bonetti G, Donato K, Medori MC, Beccari T, Samaja M, Connelly ST, Martin D, Morresi A, Bacu A, Herbst KL, Kapustin M, Stuppia L, Lumer L, Farronato G, Bertelli M; INTERNATIONAL BIOETHICS STUDY GROUP
J Prev Med Hyg 2022 Jun;63(2 Suppl 3):E267-E278. Epub 2022 Oct 17 doi: 10.15167/2421-4248/jpmh2022.63.2S3.2769. PMID: 36479476Free PMC Article
Kruppa P, Georgiou I, Biermann N, Prantl L, Klein-Weigel P, Ghods M
Dtsch Arztebl Int 2020 Jun 1;117(22-23):396-403. doi: 10.3238/arztebl.2020.0396. PMID: 32762835Free PMC Article
Pascucci A, Lynch PJ
Dermatol Online J 2010 Sep 15;16(9):4. PMID: 20875325

Recent systematic reviews

Amato ACM, Amato JLS, Benitti DA
Nutrients 2024 Sep 27;16(19) doi: 10.3390/nu16193276. PMID: 39408242Free PMC Article
van la Parra RFD, Deconinck C, Krug B
Obes Rev 2024 Jan;25(1):e13648. Epub 2023 Oct 3 doi: 10.1111/obr.13648. PMID: 37789512
Schmidt J, Kruppa P, Georgiou I, Ghods M
Clin Hemorheol Microcirc 2021;78(3):311-324. doi: 10.3233/CH-201063. PMID: 33814418
Halk AB, Damstra RJ
Phlebology 2017 Apr;32(3):152-159. Epub 2016 Jul 9 doi: 10.1177/0268355516639421. PMID: 27075680

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