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Head and neck cancer

MedGen UID:
78920
•Concept ID:
C0278996
•
Neoplastic Process
Synonyms: Cancer of Head and Neck; Cancer of the Head and Neck; Head and Neck Cancer
SNOMED CT: Malignant tumor of head and/or neck (255056009); Malignant tumor of head and neck (255056009)
 
Monarch Initiative: MONDO:0005627

Definition

A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Head and neck cancer

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
An Overview Of The Management And Rehabilitation Of Dysphagia.
Nakao-Kato M, Rathore FA
J Pak Med Assoc 2023 Aug;73(8):1749-1752. doi: 10.47391/JPMA.23-61. PMID: 37697781
Expert Consensus Statement: Management of Dysphagia in Head and Neck Cancer Patients.
Kuhn MA, Gillespie MB, Ishman SL, Ishii LE, Brody R, Cohen E, Dhar SI, Hutcheson K, Jefferson G, Johnson F, Rameau A, Sher D, Starmer H, Strohl M, Ulmer K, Vaitaitis V, Begum S, Batjargal M, Dhepyasuwan N
Otolaryngol Head Neck Surg 2023 Apr;168(4):571-592. doi: 10.1002/ohn.302. PMID: 36965195

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Recent clinical studies

Etiology

Nutritional prehabilitation in head and neck cancer: A systematic review of literature.
De Pasquale G, Mancin S, Matteucci S, Cattani D, Pastore M, Franzese C, Scorsetti M, Mazzoleni B
Clin Nutr ESPEN 2023 Dec;58:326-334. Epub 2023 Oct 31 doi: 10.1016/j.clnesp.2023.10.033. PMID: 38057023
Smoking and Head and Neck Cancer.
Yu VX, Long S, Tassler A
JAMA Otolaryngol Head Neck Surg 2023 May 1;149(5):470. doi: 10.1001/jamaoto.2023.0195. PMID: 36995722
A retrospective review of cancer surveillance in 100 head and neck cancer patients: Is there scope for a more tailored approach?
Alvi MIUR, Eagles EJ, Hamilton DW
Clin Otolaryngol 2022 Jan;47(1):207-211. Epub 2021 Oct 7 doi: 10.1111/coa.13862. PMID: 34543513
Notch in Head and Neck Cancer.
Porcheri C, Mitsiadis TA
Adv Exp Med Biol 2021;1287:81-103. doi: 10.1007/978-3-030-55031-8_7. PMID: 33034028
Follow-up program in head and neck cancer.
De Felice F, de Vincentiis M, Valentini V, Musio D, Mezi S, Lo Mele L, Terenzi V, D'Aguanno V, Cassoni A, Di Brino M, Tenore G, Bulzonetti N, Battisti A, Greco A, Pompa G, Minni A, Romeo U, Cortesi E, Polimeni A, Tombolini V
Crit Rev Oncol Hematol 2017 May;113:151-155. Epub 2017 Mar 14 doi: 10.1016/j.critrevonc.2017.03.012. PMID: 28427504

Diagnosis

Nutritional prehabilitation in head and neck cancer: A systematic review of literature.
De Pasquale G, Mancin S, Matteucci S, Cattani D, Pastore M, Franzese C, Scorsetti M, Mazzoleni B
Clin Nutr ESPEN 2023 Dec;58:326-334. Epub 2023 Oct 31 doi: 10.1016/j.clnesp.2023.10.033. PMID: 38057023
Artificial Intelligence and Deep Learning of Head and Neck Cancer.
Abdel Razek AAK, Khaled R, Helmy E, Naglah A, AbdelKhalek A, El-Baz A
Magn Reson Imaging Clin N Am 2022 Feb;30(1):81-94. doi: 10.1016/j.mric.2021.06.016. PMID: 34802583
Exosomes in cancer.
Müller Bark J, Kulasinghe A, Amenábar JM, Punyadeera C
Adv Clin Chem 2021;101:1-40. Epub 2020 Aug 18 doi: 10.1016/bs.acc.2020.06.006. PMID: 33706886
Overview of the 8th Edition TNM Classification for Head and Neck Cancer.
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375
(18)F-Fluorodeoxyglucose PET/MR Imaging in Head and Neck Cancer.
Platzek I
PET Clin 2016 Oct;11(4):375-86. Epub 2016 Jul 7 doi: 10.1016/j.cpet.2016.05.002. PMID: 27593244

Therapy

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group.
Lacas B, Carmel A, Landais C, Wong SJ, Licitra L, Tobias JS, Burtness B, Ghi MG, Cohen EEW, Grau C, Wolf G, Hitt R, Corvò R, Budach V, Kumar S, Laskar SG, Mazeron JJ, Zhong LP, Dobrowsky W, Ghadjar P, Fallai C, Zakotnik B, Sharma A, Bensadoun RJ, Ruo Redda MG, Racadot S, Fountzilas G, Brizel D, Rovea P, Argiris A, Nagy ZT, Lee JW, Fortpied C, Harris J, Bourhis J, Aupérin A, Blanchard P, Pignon JP; MACH-NC Collaborative Group
Radiother Oncol 2021 Mar;156:281-293. Epub 2021 Jan 27 doi: 10.1016/j.radonc.2021.01.013. PMID: 33515668Free PMC Article
Metronomic chemotherapy in head and neck cancer.
De Felice F, Benevento I, Musella A, Musio D, Tombolini V
Cancer Lett 2017 Aug 1;400:219-222. Epub 2016 Nov 8 doi: 10.1016/j.canlet.2016.10.047. PMID: 27832971
Toxicities associated with head and neck cancer treatment and oncology-related clinical trials.
Villa A, Sonis S
Curr Probl Cancer 2016 Sep-Dec;40(5-6):244-257. Epub 2016 Jun 17 doi: 10.1016/j.currproblcancer.2016.06.001. PMID: 27520848
Oncolytic virus therapy: A new era of cancer treatment at dawn.
Fukuhara H, Ino Y, Todo T
Cancer Sci 2016 Oct;107(10):1373-1379. Epub 2016 Sep 9 doi: 10.1111/cas.13027. PMID: 27486853Free PMC Article
Cetuximab in metastatic or recurrent head and neck cancer: the EXTREME trial.
Rivera F, García-Castaño A, Vega N, Vega-Villegas ME, Gutiérrez-Sanz L
Expert Rev Anticancer Ther 2009 Oct;9(10):1421-8. doi: 10.1586/era.09.113. PMID: 19828002

Prognosis

Mismatch repair protein loss in cutaneous head and neck squamous cell carcinoma.
Vasan K, Anand S, Satgunaseelan L, Asher R, Low H, Palme CE, Lee JH, Clark JR, Gupta R
J Surg Oncol 2020 Dec;122(8):1755-1760. Epub 2020 Sep 14 doi: 10.1002/jso.26218. PMID: 32926758
Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article
On the relation between improved loco-regional control and disease-free survival in head-and-neck cancer.
Håkansson K, Rasmussen JH, Bentzen SM, Friborg J, Specht L, Vogelius IR
Acta Oncol 2019 Mar;58(3):390-392. Epub 2019 Feb 15 doi: 10.1080/0284186X.2019.1569260. PMID: 30764696
Follow-up program in head and neck cancer.
De Felice F, de Vincentiis M, Valentini V, Musio D, Mezi S, Lo Mele L, Terenzi V, D'Aguanno V, Cassoni A, Di Brino M, Tenore G, Bulzonetti N, Battisti A, Greco A, Pompa G, Minni A, Romeo U, Cortesi E, Polimeni A, Tombolini V
Crit Rev Oncol Hematol 2017 May;113:151-155. Epub 2017 Mar 14 doi: 10.1016/j.critrevonc.2017.03.012. PMID: 28427504
Head and neck cancer in 2010: Maximizing survival and minimizing toxicity.
Brockstein BE, Vokes EE
Nat Rev Clin Oncol 2011 Feb;8(2):72-4. doi: 10.1038/nrclinonc.2010.226. PMID: 21278773

Clinical prediction guides

Prediction of Flap Compromise by Preoperative Coagulation Parameters in Head and Neck Cancer Patients.
Wu K, Lei JS, Mao YY, Cao W, Wu HJ, Ren ZH
J Oral Maxillofac Surg 2018 Nov;76(11):2453.e1-2453.e7. Epub 2018 Jul 11 doi: 10.1016/j.joms.2018.07.001. PMID: 30076809
External validation of a cancer risk prediction model for suspected head and neck cancer referrals.
Tikka T, Paleri V, MacKenzie K
Clin Otolaryngol 2018 Apr;43(2):714-717. Epub 2017 Nov 8 doi: 10.1111/coa.13019. PMID: 29054125
Cetuximab in metastatic or recurrent head and neck cancer: the EXTREME trial.
Rivera F, García-Castaño A, Vega N, Vega-Villegas ME, Gutiérrez-Sanz L
Expert Rev Anticancer Ther 2009 Oct;9(10):1421-8. doi: 10.1586/era.09.113. PMID: 19828002
Tumour volume measurement in head and neck cancer.
Chong VF
Cancer Imaging 2007 Oct 1;7 Spec No A(Special issue A):S47-9. doi: 10.1102/1470-7330.2007.9002. PMID: 17921082Free PMC Article
Predictive factors in head and neck cancer.
Bradford CR
Hematol Oncol Clin North Am 1999 Aug;13(4):777-85. doi: 10.1016/s0889-8588(05)70092-7. PMID: 10494513

Recent systematic reviews

Nutritional prehabilitation in head and neck cancer: A systematic review of literature.
De Pasquale G, Mancin S, Matteucci S, Cattani D, Pastore M, Franzese C, Scorsetti M, Mazzoleni B
Clin Nutr ESPEN 2023 Dec;58:326-334. Epub 2023 Oct 31 doi: 10.1016/j.clnesp.2023.10.033. PMID: 38057023
Artificial Intelligence in Head and Neck Cancer: A Systematic Review of Systematic Reviews.
Mäkitie AA, Alabi RO, Ng SP, Takes RP, Robbins KT, Ronen O, Shaha AR, Bradley PJ, Saba NF, Nuyts S, Triantafyllou A, Piazza C, Rinaldo A, Ferlito A
Adv Ther 2023 Aug;40(8):3360-3380. Epub 2023 Jun 8 doi: 10.1007/s12325-023-02527-9. PMID: 37291378Free PMC Article
Expert Consensus Statement: Management of Dysphagia in Head and Neck Cancer Patients.
Kuhn MA, Gillespie MB, Ishman SL, Ishii LE, Brody R, Cohen E, Dhar SI, Hutcheson K, Jefferson G, Johnson F, Rameau A, Sher D, Starmer H, Strohl M, Ulmer K, Vaitaitis V, Begum S, Batjargal M, Dhepyasuwan N
Otolaryngol Head Neck Surg 2023 Apr;168(4):571-592. doi: 10.1002/ohn.302. PMID: 36965195
Optimal Perioperative Care in Major Head and Neck Cancer Surgery With Free Flap Reconstruction: A Consensus Review and Recommendations From the Enhanced Recovery After Surgery Society.
Dort JC, Farwell DG, Findlay M, Huber GF, Kerr P, Shea-Budgell MA, Simon C, Uppington J, Zygun D, Ljungqvist O, Harris J
JAMA Otolaryngol Head Neck Surg 2017 Mar 1;143(3):292-303. doi: 10.1001/jamaoto.2016.2981. PMID: 27737447
American Cancer Society Head and Neck Cancer Survivorship Care Guideline.
Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024
    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • MeSH
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    • PMC Articles
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