U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal circulating protein concentration

MedGen UID:
892289
•Concept ID:
C4023679
•
Finding
Synonyms: Abnormal circulating protein level; Abnormality of circulating protein level; Blood protein disease; Serum protein abnormality
 
HPO: HP:0010876

Definition

An abnormal level of a circulating protein in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating protein concentration

Professional guidelines

PubMed

Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
Diagnosis and treatment of hyponatraemia.
Ball SG, Iqbal Z
Best Pract Res Clin Endocrinol Metab 2016 Mar;30(2):161-73. Epub 2015 Dec 30 doi: 10.1016/j.beem.2015.12.001. PMID: 27156756
Principles of care for the diagnosis and treatment of von Willebrand disease.
Castaman G, Goodeve A, Eikenboom J; European Group on von Willebrand Disease
Haematologica 2013 May;98(5):667-74. doi: 10.3324/haematol.2012.077263. PMID: 23633542Free PMC Article

Recent clinical studies

Etiology

Nuclear Magnetic Resonance-Based Metabolomics and Risk of CKD.
Geng TT, Chen JX, Lu Q, Wang PL, Xia PF, Zhu K, Li Y, Guo KQ, Yang K, Liao YF, Zhou YF, Liu G, Pan A
Am J Kidney Dis 2024 Jan;83(1):9-17. Epub 2023 Sep 9 doi: 10.1053/j.ajkd.2023.05.014. PMID: 37678743
Predicting Major Adverse Cardiovascular Events in Children With Age-Adjusted NT-proBNP.
Palm J, Holdenrieder S, Hoffmann G, Hörer J, Shi R, Klawonn F, Ewert P
J Am Coll Cardiol 2021 Nov 9;78(19):1890-1900. doi: 10.1016/j.jacc.2021.08.056. PMID: 34736565
Natural Antibodies Against Sialoglycans.
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491
Mechanisms of hepatic chylomicron remnant clearance.
Willnow TE
Diabet Med 1997 Aug;14 Suppl 3:S75-80. doi: 10.1002/(sici)1096-9136(199708)14:3+<s75::aid-dia449>3.3.co;2-0. PMID: 9272618
Lipids, risk factors and ischaemic heart disease.
Castelli WP
Atherosclerosis 1996 Jul;124 Suppl:S1-9. doi: 10.1016/0021-9150(96)05851-0. PMID: 8831910

Diagnosis

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Wilson disease.
Guindi M
Semin Diagn Pathol 2019 Nov;36(6):415-422. Epub 2019 Jul 25 doi: 10.1053/j.semdp.2019.07.008. PMID: 31421978
New insights into thyroid hormone action.
Mendoza A, Hollenberg AN
Pharmacol Ther 2017 May;173:135-145. Epub 2017 Feb 4 doi: 10.1016/j.pharmthera.2017.02.012. PMID: 28174093Free PMC Article
Contribution of triglyceride-rich lipoproteins to plasma free fatty acids.
Miles JM, Nelson RH
Horm Metab Res 2007 Oct;39(10):726-9. doi: 10.1055/s-2007-990273. PMID: 17952834
Diabetes insipidus.
Blevins LS Jr, Wand GS
Crit Care Med 1992 Jan;20(1):69-79. doi: 10.1097/00003246-199201000-00019. PMID: 1729049

Therapy

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Factors influencing the levothyroxine dose in the hormone replacement therapy of primary hypothyroidism in adults.
Caron P, Grunenwald S, Persani L, Borson-Chazot F, Leroy R, Duntas L
Rev Endocr Metab Disord 2022 Jun;23(3):463-483. Epub 2021 Oct 20 doi: 10.1007/s11154-021-09691-9. PMID: 34671932Free PMC Article
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Obstructive nephropathy.
Klahr S
Intern Med 2000 May;39(5):355-61. doi: 10.2169/internalmedicine.39.355. PMID: 10830173
Thyroid function in nonthyroidal illnesses.
Chopra IJ, Hershman JM, Pardridge WM, Nicoloff JT
Ann Intern Med 1983 Jun;98(6):946-57. doi: 10.7326/0003-4819-98-6-946. PMID: 6407376

Prognosis

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
High-Density Lipoproteins and the Kidney.
Strazzella A, Ossoli A, Calabresi L
Cells 2021 Mar 31;10(4) doi: 10.3390/cells10040764. PMID: 33807271Free PMC Article
Metabolic effects of the menopause and oestrogen replacement.
Stevenson JC
Baillieres Clin Obstet Gynaecol 1996 Sep;10(3):449-67. doi: 10.1016/s0950-3552(96)80025-3. PMID: 8931905
Thyroid function in nonthyroidal illnesses.
Chopra IJ, Hershman JM, Pardridge WM, Nicoloff JT
Ann Intern Med 1983 Jun;98(6):946-57. doi: 10.7326/0003-4819-98-6-946. PMID: 6407376
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

Clinical prediction guides

Nuclear Magnetic Resonance-Based Metabolomics and Risk of CKD.
Geng TT, Chen JX, Lu Q, Wang PL, Xia PF, Zhu K, Li Y, Guo KQ, Yang K, Liao YF, Zhou YF, Liu G, Pan A
Am J Kidney Dis 2024 Jan;83(1):9-17. Epub 2023 Sep 9 doi: 10.1053/j.ajkd.2023.05.014. PMID: 37678743
Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease.
Amaya-Garrido A, Brunet M, Buffin-Meyer B, Piedrafita A, Grzesiak L, Agbegbo E, Del Bello A, Ferrandiz I, Ardeleanu S, Bermudez-Lopez M, Fedou C, Camus M, Burlet-Schiltz O, Massines J, Buléon M, Feuillet G, Alves M, Neau E, Casemayou A, Breuil B, Saulnier-Blache JS, Denis C, Voelkl J, Glorieux G, Hobson S, Arefin S, Rahman A, Kublickiene K, Stenvinkel P, Bascands JL, Faguer S, Valdivielso JM, Schanstra JP, Klein J
Sci Transl Med 2023 Sep 6;15(712):eabn5939. doi: 10.1126/scitranslmed.abn5939. PMID: 37672568
Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury.
Liu Q, Wu J, Zhang X, Li X, Wu X, Zhao Y, Ren J
Cell Death Dis 2021 Jul 3;12(7):673. doi: 10.1038/s41419-021-03961-9. PMID: 34218252Free PMC Article
The spectrum of growth-hormone insensitivity.
Parks JS, Brown MR, Faase ME
J Pediatr 1997 Jul;131(1 Pt 2):S45-50. doi: 10.1016/s0022-3476(97)70011-8. PMID: 9255228
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

Recent systematic reviews

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Alcohol use disorder and circulating cytokines: A systematic review and meta-analysis.
Adams C, Conigrave JH, Lewohl J, Haber P, Morley KC
Brain Behav Immun 2020 Oct;89:501-512. Epub 2020 Aug 14 doi: 10.1016/j.bbi.2020.08.002. PMID: 32805393
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
The Role of Endothelin in the Pathophysiology of Migraine-a Systematic Review.
Iljazi A, Ayata C, Ashina M, Hougaard A
Curr Pain Headache Rep 2018 Mar 19;22(4):27. doi: 10.1007/s11916-018-0682-8. PMID: 29557064
Chronic fatigue syndrome and circulating cytokines: A systematic review.
Blundell S, Ray KK, Buckland M, White PD
Brain Behav Immun 2015 Nov;50:186-195. Epub 2015 Jul 3 doi: 10.1016/j.bbi.2015.07.004. PMID: 26148446

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...