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Core binding factor acute myeloid leukemia

MedGen UID:
825586
Concept ID:
C3839741
Neoplastic Process
Synonyms: CBF-AML - core binding factor acute myeloid leukemia; Core Binding Factor Acute Myeloid Leukemia; core binding factor acute myeloid leukemia
SNOMED CT: Core binding factor acute myeloid leukemia (702446006); CBF-AML - core binding factor acute myeloid leukemia (702446006)
 
Monarch Initiative: MONDO:0850269

Definition

Form of acute myeloid leukaemia having a shortage of all types of mature blood cells with onset in childhood or young adulthood. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCore binding factor acute myeloid leukemia

Professional guidelines

PubMed

Ustun C, Morgan EA, Ritz EM, Vestergaard H, Pullarkat S, Kluin PM, Ohgami R, Baughn LB, Kim Y, Ku NK, Czuchlewski D, Boe Møller M, Schiefer AI, Mrózek K, Horny HP, George TI, Kielsgaard Kristensen T, Beck T, Nathan S, Arana Yi C, Yeung C, Pullarkat V, Gotlib J, Akin C, Kohlschmidt J, Salhotra A, Soma L, Chen D, Han SY, Cho C, Sperr W, Broesby-Olsen S, Linden MA, Dolan M, Hoermann G, Hornick JL, Bloomfield C, Nakamura R, Joachim Deeg H, Litzow MR, Borthakur G, Weisdorf D, Huls G, Perales MA, Valent P, Marcucci G
Int J Lab Hematol 2021 Feb;43(1):e19-e25. Epub 2020 Sep 14 doi: 10.1111/ijlh.13338. PMID: 32926565Free PMC Article
Borthakur G
Clin Adv Hematol Oncol 2020 Nov;18(11):691-694. PMID: 33406060
Litzow MR
Haematologica 2020 Jun;105(6):1475-1477. doi: 10.3324/haematol.2020.249110. PMID: 32482754Free PMC Article

Recent clinical studies

Etiology

Darwish C, Farina K, Tremblay D
Blood Rev 2023 Nov;62:101117. Epub 2023 Jul 25 doi: 10.1016/j.blre.2023.101117. PMID: 37524647
Ishikawa Y, Kawashima N, Atsuta Y, Sugiura I, Sawa M, Dobashi N, Yokoyama H, Doki N, Tomita A, Kiguchi T, Koh S, Kanamori H, Iriyama N, Kohno A, Moriuchi Y, Asada N, Hirano D, Togitani K, Sakura T, Hagihara M, Tomikawa T, Yokoyama Y, Asou N, Ohtake S, Matsumura I, Miyazaki Y, Naoe T, Kiyoi H
Blood Adv 2020 Jan 14;4(1):66-75. doi: 10.1182/bloodadvances.2019000709. PMID: 31899799Free PMC Article
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article
Sinha C, Cunningham LC, Liu PP
Semin Hematol 2015 Jul;52(3):215-22. Epub 2015 Apr 7 doi: 10.1053/j.seminhematol.2015.04.002. PMID: 26111469Free PMC Article
Solh M, Yohe S, Weisdorf D, Ustun C
Am J Hematol 2014 Dec;89(12):1121-31. Epub 2014 Aug 27 doi: 10.1002/ajh.23821. PMID: 25088818

Diagnosis

Cook JA, Lott L, Perry J, Eckel AM, Xu D, Hudson CA, Wells DA, Loken MR, Menssen AJ
Blood 2024 Aug 1;144(5):581-585. doi: 10.1182/blood.2024024264. PMID: 38749014
Darwish C, Farina K, Tremblay D
Blood Rev 2023 Nov;62:101117. Epub 2023 Jul 25 doi: 10.1016/j.blre.2023.101117. PMID: 37524647
Ishikawa Y, Kawashima N, Atsuta Y, Sugiura I, Sawa M, Dobashi N, Yokoyama H, Doki N, Tomita A, Kiguchi T, Koh S, Kanamori H, Iriyama N, Kohno A, Moriuchi Y, Asada N, Hirano D, Togitani K, Sakura T, Hagihara M, Tomikawa T, Yokoyama Y, Asou N, Ohtake S, Matsumura I, Miyazaki Y, Naoe T, Kiyoi H
Blood Adv 2020 Jan 14;4(1):66-75. doi: 10.1182/bloodadvances.2019000709. PMID: 31899799Free PMC Article
Sinha C, Cunningham LC, Liu PP
Semin Hematol 2015 Jul;52(3):215-22. Epub 2015 Apr 7 doi: 10.1053/j.seminhematol.2015.04.002. PMID: 26111469Free PMC Article
Lim KH, Pardanani A, Tefferi A
Acta Haematol 2008;119(4):194-8. Epub 2008 Jun 20 doi: 10.1159/000140630. PMID: 18566536

Therapy

Darwish C, Farina K, Tremblay D
Blood Rev 2023 Nov;62:101117. Epub 2023 Jul 25 doi: 10.1016/j.blre.2023.101117. PMID: 37524647
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article
Solh M, Yohe S, Weisdorf D, Ustun C
Am J Hematol 2014 Dec;89(12):1121-31. Epub 2014 Aug 27 doi: 10.1002/ajh.23821. PMID: 25088818
Bhatt VR, Kantarjian H, Cortes JE, Ravandi F, Borthakur G
Clin Lymphoma Myeloma Leuk 2013 Apr;13(2):153-8. Epub 2012 Dec 21 doi: 10.1016/j.clml.2012.11.006. PMID: 23266036Free PMC Article
Bloomfield CD, Ruppert AS, Mrózek K, Kolitz JE, Moore JO, Mayer RJ, Edwards CG, Sterling LJ, Vardiman JW, Carroll AJ, Pettenati MJ, Stamberg J, Byrd JC, Marcucci G, Larson RA; Cancer and Leukemia Group B (CALGB) Study 8461
Ann Hematol 2004;83 Suppl 1:S84-5. doi: 10.1007/s00277-004-0850-2. PMID: 15124687

Prognosis

Darwish C, Farina K, Tremblay D
Blood Rev 2023 Nov;62:101117. Epub 2023 Jul 25 doi: 10.1016/j.blre.2023.101117. PMID: 37524647
Ishikawa Y, Kawashima N, Atsuta Y, Sugiura I, Sawa M, Dobashi N, Yokoyama H, Doki N, Tomita A, Kiguchi T, Koh S, Kanamori H, Iriyama N, Kohno A, Moriuchi Y, Asada N, Hirano D, Togitani K, Sakura T, Hagihara M, Tomikawa T, Yokoyama Y, Asou N, Ohtake S, Matsumura I, Miyazaki Y, Naoe T, Kiyoi H
Blood Adv 2020 Jan 14;4(1):66-75. doi: 10.1182/bloodadvances.2019000709. PMID: 31899799Free PMC Article
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article
Sinha C, Cunningham LC, Liu PP
Semin Hematol 2015 Jul;52(3):215-22. Epub 2015 Apr 7 doi: 10.1053/j.seminhematol.2015.04.002. PMID: 26111469Free PMC Article
Duployez N, Willekens C, Marceau-Renaut A, Boudry-Labis E, Preudhomme C
Expert Rev Hematol 2015 Feb;8(1):43-56. Epub 2014 Oct 28 doi: 10.1586/17474086.2014.976551. PMID: 25348871

Clinical prediction guides

Mosna F, Borlenghi E, Litzow M, Byrd JC, Papayannidis C, Tecchio C, Ferrara F, Marcucci G, Cairoli R, Morgan EA, Gurrieri C, Yeung CCS, Deeg HJ, Capelli D, Candoni A, Gotlib JR, Lunghi M, Pullarkat S, Lanza F, Galimberti S, Forghieri F, Venditti A, Festuccia M, Audisio E, Marvalle D, Rigolin GM, Roti G, DiBona E, Visani G, Albano F, Eisfeld AK, Valent P, Huls G, Borthakur G, Krampera M, Martinelli G, Kröger N, Sperotto A, Gottardi M
Haematologica 2025 Mar 1;110(3):608-620. doi: 10.3324/haematol.2024.285448. PMID: 39385741Free PMC Article
Al Hamed R, Labopin M, Wu D, Gedde-Dahl T, Aljurf M, Forcade E, Salmenniemi U, Passweg J, Maertens J, Pabst T, Versluis J, Itäla-Remes M, Huang XJ, Van Gorkom G, Schroeder T, Sanz J, Blaise D, Reményi P, Schanz U, Esteve J, Gorin NC, Ciceri F, Mohty M
Bone Marrow Transplant 2024 Oct;59(10):1458-1465. Epub 2024 Aug 2 doi: 10.1038/s41409-024-02373-5. PMID: 39095548
Duan W, Liu X, Zhao X, Jia J, Wang J, Gong L, Jiang Q, Zhao T, Wang Y, Zhang X, Xu L, Shi H, Chang Y, Liu K, Huang X, Qin Y, Jiang H
Ann Hematol 2021 May;100(5):1203-1212. Epub 2021 Jan 20 doi: 10.1007/s00277-021-04432-z. PMID: 33474629
Chung C, Ma H
Pharmacotherapy 2017 Sep;37(9):1052-1072. Epub 2017 Jul 31 doi: 10.1002/phar.1977. PMID: 28654205
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article

Recent systematic reviews

Srinivasan S, Kumar S, Vijayasekharan K, Agrawal AK
Clin Lymphoma Myeloma Leuk 2022 Apr;22(4):e221-e232. Epub 2021 Oct 2 doi: 10.1016/j.clml.2021.09.020. PMID: 34750085
Ayatollahi H, Shajiei A, Sadeghian MH, Sheikhi M, Yazdandoust E, Ghazanfarpour M, Shams SF, Shakeri S
Hematol Oncol Stem Cell Ther 2017 Mar;10(1):1-7. Epub 2016 Sep 3 doi: 10.1016/j.hemonc.2016.08.005. PMID: 27613372
Chen W, Xie H, Wang H, Chen L, Sun Y, Chen Z, Li Q
PLoS One 2016;11(1):e0146614. Epub 2016 Jan 15 doi: 10.1371/journal.pone.0146614. PMID: 26771376Free PMC Article

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