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Luminal B breast carcinoma

MedGen UID:
770986
•Concept ID:
C3642346
•
Neoplastic Process
Synonyms: Luminal B; Luminal B Breast Cancer; Luminal B breast cancer; Luminal B Breast Carcinoma; luminal B breast carcinoma; Luminal B Estrogen Receptor Positive Subtype of Breast Carcinoma; Luminal B estrogen receptor positive subtype of breast carcinoma; Luminal B oestrogen receptor positive subtype of breast carcinoma; Luminal B Subtype of Breast Carcinoma; Luminal B subtype of breast carcinoma
 
Monarch Initiative: MONDO:0021115

Definition

A biologic subset of breast carcinoma defined by low to moderate expression of genes characteristic of luminal epithelial cells including estrogen receptor (ER), and high expression of GGH, LAPTM4B, and CCNE1. This subtype of breast cancer is associated with a good prognosis, although not as favorable as the luminal A subtype. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLuminal B breast carcinoma

Professional guidelines

PubMed

The Clinical Utility of lncRNAs and Their Application as Molecular Biomarkers in Breast Cancer.
Arriaga-Canon C, Contreras-Espinosa L, Aguilar-Villanueva S, Bargalló-Rocha E, García-Gordillo JA, Cabrera-Galeana P, Castro-Hernández C, Jiménez-Trejo F, Herrera LA
Int J Mol Sci 2023 Apr 18;24(8) doi: 10.3390/ijms24087426. PMID: 37108589Free PMC Article
Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies.
Wolf DM, Yau C, Wulfkuhle J, Brown-Swigart L, Gallagher RI, Lee PRE, Zhu Z, Magbanua MJ, Sayaman R, O'Grady N, Basu A, Delson A, Coppé JP, Lu R, Braun J; I-SPY2 Investigators, Asare SM, Sit L, Matthews JB, Perlmutter J, Hylton N, Liu MC, Pohlmann P, Symmans WF, Rugo HS, Isaacs C, DeMichele AM, Yee D, Berry DA, Pusztai L, Petricoin EF, Hirst GL, Esserman LJ, van 't Veer LJ
Cancer Cell 2022 Jun 13;40(6):609-623.e6. Epub 2022 May 26 doi: 10.1016/j.ccell.2022.05.005. PMID: 35623341Free PMC Article
Luminal B breast cancer: molecular characterization, clinical management, and future perspectives.
Ades F, Zardavas D, Bozovic-Spasojevic I, Pugliano L, Fumagalli D, de Azambuja E, Viale G, Sotiriou C, Piccart M
J Clin Oncol 2014 Sep 1;32(25):2794-803. Epub 2014 Jul 21 doi: 10.1200/JCO.2013.54.1870. PMID: 25049332

Recent clinical studies

Diagnosis

Comparison of visual assessment and image analysis in the evaluation of Ki-67 expression and their prognostic significance in immunohistochemically defined luminal breast carcinoma.
Arihiro K, Oda M, Ohara M, Kadoya T, Osaki A, Nishisaka T, Shiroma N, Kobayashi Y
Jpn J Clin Oncol 2016 Dec;46(12):1081-1087. Epub 2016 Aug 10 doi: 10.1093/jjco/hyw107. PMID: 27511992

Prognosis

Comparison of visual assessment and image analysis in the evaluation of Ki-67 expression and their prognostic significance in immunohistochemically defined luminal breast carcinoma.
Arihiro K, Oda M, Ohara M, Kadoya T, Osaki A, Nishisaka T, Shiroma N, Kobayashi Y
Jpn J Clin Oncol 2016 Dec;46(12):1081-1087. Epub 2016 Aug 10 doi: 10.1093/jjco/hyw107. PMID: 27511992

Clinical prediction guides

Comparison of visual assessment and image analysis in the evaluation of Ki-67 expression and their prognostic significance in immunohistochemically defined luminal breast carcinoma.
Arihiro K, Oda M, Ohara M, Kadoya T, Osaki A, Nishisaka T, Shiroma N, Kobayashi Y
Jpn J Clin Oncol 2016 Dec;46(12):1081-1087. Epub 2016 Aug 10 doi: 10.1093/jjco/hyw107. PMID: 27511992

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