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Breast carcinoma by gene expression profile

MedGen UID:
770984
•Concept ID:
C3642344
•
Neoplastic Process
Synonyms: Breast Carcinoma by Gene Expression Profile; breast carcinoma by gene expression profile
 
Monarch Initiative: MONDO:0006116

Definition

A header term that includes the following breast carcinoma subtypes determined by gene expression profiling: luminal A breast carcinoma, luminal B breast carcinoma, HER2 positive breast carcinoma, basal-like breast carcinoma, triple-negative breast carcinoma, and normal breast-like subtype of breast carcinoma. [from NCI]

Professional guidelines

PubMed

Triple-negative breast cancer: epidemiology, molecular mechanisms, and modern vaccine-based treatment strategies.
Karim AM, Eun Kwon J, Ali T, Jang J, Ullah I, Lee YG, Park DW, Park J, Jeang JW, Kang SC
Biochem Pharmacol 2023 Jun;212:115545. Epub 2023 Apr 11 doi: 10.1016/j.bcp.2023.115545. PMID: 37044296
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer.
Bassez A, Vos H, Van Dyck L, Floris G, Arijs I, Desmedt C, Boeckx B, Vanden Bempt M, Nevelsteen I, Lambein K, Punie K, Neven P, Garg AD, Wildiers H, Qian J, Smeets A, Lambrechts D
Nat Med 2021 May;27(5):820-832. Epub 2021 May 6 doi: 10.1038/s41591-021-01323-8. PMID: 33958794
Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.
Jiang YZ, Ma D, Suo C, Shi J, Xue M, Hu X, Xiao Y, Yu KD, Liu YR, Yu Y, Zheng Y, Li X, Zhang C, Hu P, Zhang J, Hua Q, Zhang J, Hou W, Ren L, Bao D, Li B, Yang J, Yao L, Zuo WJ, Zhao S, Gong Y, Ren YX, Zhao YX, Yang YS, Niu Z, Cao ZG, Stover DG, Verschraegen C, Kaklamani V, Daemen A, Benson JR, Takabe K, Bai F, Li DQ, Wang P, Shi L, Huang W, Shao ZM
Cancer Cell 2019 Mar 18;35(3):428-440.e5. Epub 2019 Mar 7 doi: 10.1016/j.ccell.2019.02.001. PMID: 30853353

Recent clinical studies

Etiology

Single-cell transcriptome sequencing of B-cell heterogeneity and tertiary lymphoid structure predicts breast cancer prognosis and neoadjuvant therapy efficacy.
Wang Q, Sun K, Liu R, Song Y, Lv Y, Bi P, Yang F, Li S, Zhao J, Li X, Chen D, Mei J, Yang R, Chen K, Liu D, Tang S
Clin Transl Med 2023 Aug;13(8):e1346. doi: 10.1002/ctm2.1346. PMID: 37525587Free PMC Article
Biomarkers in Breast Cancer: An Old Story with a New End.
Neves Rebello Alves L, Dummer Meira D, Poppe Merigueti L, Correia Casotti M, do Prado Ventorim D, Ferreira Figueiredo Almeida J, Pereira de Sousa V, Cindra Sant'Ana M, Gonçalves Coutinho da Cruz R, Santos Louro L, Mendonça Santana G, Erik Santos Louro T, Evangelista Salazar R, Ribeiro Campos da Silva D, Stefani Siqueira Zetum A, Silva Dos Reis Trabach R, Imbroisi Valle Errera F, de Paula F, de Vargas Wolfgramm Dos Santos E, Fagundes de Carvalho E, Drumond Louro I
Genes (Basel) 2023 Jun 28;14(7) doi: 10.3390/genes14071364. PMID: 37510269Free PMC Article
Exploring the causality and pathogenesis of systemic lupus erythematosus in breast cancer based on Mendelian randomization and transcriptome data analyses.
Li W, Wang R, Wang W
Front Immunol 2022;13:1029884. Epub 2023 Jan 16 doi: 10.3389/fimmu.2022.1029884. PMID: 36726984Free PMC Article
A human breast atlas integrating single-cell proteomics and transcriptomics.
Gray GK, Li CM, Rosenbluth JM, Selfors LM, Girnius N, Lin JR, Schackmann RCJ, Goh WL, Moore K, Shapiro HK, Mei S, D'Andrea K, Nathanson KL, Sorger PK, Santagata S, Regev A, Garber JE, Dillon DA, Brugge JS
Dev Cell 2022 Jun 6;57(11):1400-1420.e7. Epub 2022 May 25 doi: 10.1016/j.devcel.2022.05.003. PMID: 35617956Free PMC Article
Comprehensive metabolomics expands precision medicine for triple-negative breast cancer.
Xiao Y, Ma D, Yang YS, Yang F, Ding JH, Gong Y, Jiang L, Ge LP, Wu SY, Yu Q, Zhang Q, Bertucci F, Sun Q, Hu X, Li DQ, Shao ZM, Jiang YZ
Cell Res 2022 May;32(5):477-490. Epub 2022 Feb 1 doi: 10.1038/s41422-022-00614-0. PMID: 35105939Free PMC Article

Diagnosis

Genetic Testing Enhances the Precision Diagnosis and Treatment of Breast Cancer.
Yang T, Li W, Huang T, Zhou J
Int J Mol Sci 2023 Nov 22;24(23) doi: 10.3390/ijms242316607. PMID: 38068930Free PMC Article
Biomarkers in Breast Cancer: An Old Story with a New End.
Neves Rebello Alves L, Dummer Meira D, Poppe Merigueti L, Correia Casotti M, do Prado Ventorim D, Ferreira Figueiredo Almeida J, Pereira de Sousa V, Cindra Sant'Ana M, Gonçalves Coutinho da Cruz R, Santos Louro L, Mendonça Santana G, Erik Santos Louro T, Evangelista Salazar R, Ribeiro Campos da Silva D, Stefani Siqueira Zetum A, Silva Dos Reis Trabach R, Imbroisi Valle Errera F, de Paula F, de Vargas Wolfgramm Dos Santos E, Fagundes de Carvalho E, Drumond Louro I
Genes (Basel) 2023 Jun 28;14(7) doi: 10.3390/genes14071364. PMID: 37510269Free PMC Article
Combined Single-Cell and Spatial Transcriptomics Reveal the Metabolic Evolvement of Breast Cancer during Early Dissemination.
Liu YM, Ge JY, Chen YF, Liu T, Chen L, Liu CC, Ma D, Chen YY, Cai YW, Xu YY, Shao ZM, Yu KD
Adv Sci (Weinh) 2023 Feb;10(6):e2205395. Epub 2023 Jan 3 doi: 10.1002/advs.202205395. PMID: 36594618Free PMC Article
Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery.
Zou Y, Xie J, Zheng S, Liu W, Tang Y, Tian W, Deng X, Wu L, Zhang Y, Wong CW, Tan D, Liu Q, Xie X
Int J Surg 2022 Nov;107:106936. Epub 2022 Sep 20 doi: 10.1016/j.ijsu.2022.106936. PMID: 36341760
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities.
Xu X, Zhang M, Xu F, Jiang S
Mol Cancer 2020 Nov 24;19(1):165. doi: 10.1186/s12943-020-01276-5. PMID: 33234169Free PMC Article

Therapy

Exploring the causality and pathogenesis of systemic lupus erythematosus in breast cancer based on Mendelian randomization and transcriptome data analyses.
Li W, Wang R, Wang W
Front Immunol 2022;13:1029884. Epub 2023 Jan 16 doi: 10.3389/fimmu.2022.1029884. PMID: 36726984Free PMC Article
Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery.
Zou Y, Xie J, Zheng S, Liu W, Tang Y, Tian W, Deng X, Wu L, Zhang Y, Wong CW, Tan D, Liu Q, Xie X
Int J Surg 2022 Nov;107:106936. Epub 2022 Sep 20 doi: 10.1016/j.ijsu.2022.106936. PMID: 36341760
Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing.
Kim C, Gao R, Sei E, Brandt R, Hartman J, Hatschek T, Crosetto N, Foukakis T, Navin NE
Cell 2018 May 3;173(4):879-893.e13. Epub 2018 Apr 19 doi: 10.1016/j.cell.2018.03.041. PMID: 29681456Free PMC Article
CDK4/6 inhibition triggers anti-tumour immunity.
Goel S, DeCristo MJ, Watt AC, BrinJones H, Sceneay J, Li BB, Khan N, Ubellacker JM, Xie S, Metzger-Filho O, Hoog J, Ellis MJ, Ma CX, Ramm S, Krop IE, Winer EP, Roberts TM, Kim HJ, McAllister SS, Zhao JJ
Nature 2017 Aug 24;548(7668):471-475. Epub 2017 Aug 16 doi: 10.1038/nature23465. PMID: 28813415Free PMC Article
70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer.
Cardoso F, van't Veer LJ, Bogaerts J, Slaets L, Viale G, Delaloge S, Pierga JY, Brain E, Causeret S, DeLorenzi M, Glas AM, Golfinopoulos V, Goulioti T, Knox S, Matos E, Meulemans B, Neijenhuis PA, Nitz U, Passalacqua R, Ravdin P, Rubio IT, Saghatchian M, Smilde TJ, Sotiriou C, Stork L, Straehle C, Thomas G, Thompson AM, van der Hoeven JM, Vuylsteke P, Bernards R, Tryfonidis K, Rutgers E, Piccart M; MINDACT Investigators
N Engl J Med 2016 Aug 25;375(8):717-29. doi: 10.1056/NEJMoa1602253. PMID: 27557300

Prognosis

Single-cell transcriptome sequencing of B-cell heterogeneity and tertiary lymphoid structure predicts breast cancer prognosis and neoadjuvant therapy efficacy.
Wang Q, Sun K, Liu R, Song Y, Lv Y, Bi P, Yang F, Li S, Zhao J, Li X, Chen D, Mei J, Yang R, Chen K, Liu D, Tang S
Clin Transl Med 2023 Aug;13(8):e1346. doi: 10.1002/ctm2.1346. PMID: 37525587Free PMC Article
Biomarkers in Breast Cancer: An Old Story with a New End.
Neves Rebello Alves L, Dummer Meira D, Poppe Merigueti L, Correia Casotti M, do Prado Ventorim D, Ferreira Figueiredo Almeida J, Pereira de Sousa V, Cindra Sant'Ana M, Gonçalves Coutinho da Cruz R, Santos Louro L, Mendonça Santana G, Erik Santos Louro T, Evangelista Salazar R, Ribeiro Campos da Silva D, Stefani Siqueira Zetum A, Silva Dos Reis Trabach R, Imbroisi Valle Errera F, de Paula F, de Vargas Wolfgramm Dos Santos E, Fagundes de Carvalho E, Drumond Louro I
Genes (Basel) 2023 Jun 28;14(7) doi: 10.3390/genes14071364. PMID: 37510269Free PMC Article
Deciphering breast cancer: from biology to the clinic.
Nolan E, Lindeman GJ, Visvader JE
Cell 2023 Apr 13;186(8):1708-1728. Epub 2023 Mar 16 doi: 10.1016/j.cell.2023.01.040. PMID: 36931265
Exploring the causality and pathogenesis of systemic lupus erythematosus in breast cancer based on Mendelian randomization and transcriptome data analyses.
Li W, Wang R, Wang W
Front Immunol 2022;13:1029884. Epub 2023 Jan 16 doi: 10.3389/fimmu.2022.1029884. PMID: 36726984Free PMC Article
Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery.
Zou Y, Xie J, Zheng S, Liu W, Tang Y, Tian W, Deng X, Wu L, Zhang Y, Wong CW, Tan D, Liu Q, Xie X
Int J Surg 2022 Nov;107:106936. Epub 2022 Sep 20 doi: 10.1016/j.ijsu.2022.106936. PMID: 36341760

Clinical prediction guides

Single-cell transcriptome sequencing of B-cell heterogeneity and tertiary lymphoid structure predicts breast cancer prognosis and neoadjuvant therapy efficacy.
Wang Q, Sun K, Liu R, Song Y, Lv Y, Bi P, Yang F, Li S, Zhao J, Li X, Chen D, Mei J, Yang R, Chen K, Liu D, Tang S
Clin Transl Med 2023 Aug;13(8):e1346. doi: 10.1002/ctm2.1346. PMID: 37525587Free PMC Article
Biomarkers in Breast Cancer: An Old Story with a New End.
Neves Rebello Alves L, Dummer Meira D, Poppe Merigueti L, Correia Casotti M, do Prado Ventorim D, Ferreira Figueiredo Almeida J, Pereira de Sousa V, Cindra Sant'Ana M, Gonçalves Coutinho da Cruz R, Santos Louro L, Mendonça Santana G, Erik Santos Louro T, Evangelista Salazar R, Ribeiro Campos da Silva D, Stefani Siqueira Zetum A, Silva Dos Reis Trabach R, Imbroisi Valle Errera F, de Paula F, de Vargas Wolfgramm Dos Santos E, Fagundes de Carvalho E, Drumond Louro I
Genes (Basel) 2023 Jun 28;14(7) doi: 10.3390/genes14071364. PMID: 37510269Free PMC Article
Exploring the causality and pathogenesis of systemic lupus erythematosus in breast cancer based on Mendelian randomization and transcriptome data analyses.
Li W, Wang R, Wang W
Front Immunol 2022;13:1029884. Epub 2023 Jan 16 doi: 10.3389/fimmu.2022.1029884. PMID: 36726984Free PMC Article
Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery.
Zou Y, Xie J, Zheng S, Liu W, Tang Y, Tian W, Deng X, Wu L, Zhang Y, Wong CW, Tan D, Liu Q, Xie X
Int J Surg 2022 Nov;107:106936. Epub 2022 Sep 20 doi: 10.1016/j.ijsu.2022.106936. PMID: 36341760
Gene expression profiling predicts clinical outcome of breast cancer.
van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, Friend SH
Nature 2002 Jan 31;415(6871):530-6. doi: 10.1038/415530a. PMID: 11823860

Recent systematic reviews

Gene expression signatures in older patients with breast cancer: A systematic review.
Lemij AA, Baltussen JC, de Glas NA, Kroep JR, Derks MGM, Liefers GJ, Portielje JEA
Crit Rev Oncol Hematol 2023 Jan;181:103884. Epub 2022 Nov 26 doi: 10.1016/j.critrevonc.2022.103884. PMID: 36442749
Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review.
Battisti NML, De Glas N, Soto-Perez-de-Celis E, Liposits G, Bringuier M, Walko C, Lichtman SM, Aapro M, Cheung KL, Biganzoli L, Ring A, Portielje J, Wildiers H, Brain E
Eur J Cancer 2022 Sep;172:158-170. Epub 2022 Jun 28 doi: 10.1016/j.ejca.2022.05.039. PMID: 35777273Free PMC Article
Prognostic role of EGR1 in breast cancer: a systematic review.
Saha SK, Islam SMR, Saha T, Nishat A, Biswas PK, Gil M, Nkenyereye L, El-Sappagh S, Islam MS, Cho SG
BMB Rep 2021 Oct;54(10):497-504. doi: 10.5483/BMBRep.2021.54.10.087. PMID: 34488929Free PMC Article
PD-1 protein and gene expression as prognostic factors in early breast cancer.
Matikas A, Zerdes I, Lövrot J, Sifakis E, Richard F, Sotiriou C, Rassidakis G, Bergh J, Valachis A, Foukakis T
ESMO Open 2020 Nov;5(6):e001032. doi: 10.1136/esmoopen-2020-001032. PMID: 33172959Free PMC Article
Target therapy for metastatic breast cancer.
Rachdi H, Mokrani A, Batti R, Ayadi M, Chraiet N, Mezlini A
Tunis Med 2018 Aug-Sep;96(8-9):465-471. PMID: 30430522

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