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Hematologic disorder

MedGen UID:
5483
Concept ID:
C0018939
Disease or Syndrome
Synonyms: Hematologic disease; Hematologic disorders; Rare hematologic disease
SNOMED CT: Disease of blood AND/OR blood forming organ (34093004); Disorder of hematopoietic system (34093004); Hematopoietic system syndrome (34093004); Hematologic disease (34093004); Blood dyscrasia (34093004); Blood disorder (34093004); Hemopoietic disorder (34093004); Hemopoietic disease (34093004); Disease of blood AND/OR blood-forming organ (191124002); Diseases of blood and blood-forming organs (191124002)
 
Monarch Initiative: MONDO:0005570
Orphanet: ORPHA97992

Definition

A non-neoplastic or neoplastic disorder that arises from the hematopoietic and lymphoid cells. Representative examples include disorders that affect the synthesis of hemoglobin, coagulation disorders, leukemias, and lymphomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHematologic disorder

Professional guidelines

PubMed

Shimano KA, Rothman JA, Allen SW, Castillo P, de Jong JLO, Dror Y, Geddis AE, Lau BW, McGuinn C, Narla A, Overholt K, Pereda MA, Sharathkumar A, Sasa G, Nakano TA, Myers K, Gloude NJ, Broglie L, Boklan J
Pediatr Blood Cancer 2024 Aug;71(8):e31070. Epub 2024 May 16 doi: 10.1002/pbc.31070. PMID: 38757488
Ciftciler R, Haznedaroglu IC
Eur Rev Med Pharmacol Sci 2021 Dec;25(24):7787-7798. doi: 10.26355/eurrev_202112_27625. PMID: 34982440
Pozzato G, Mazzaro C, Gattei V
Clin Liver Dis 2017 Aug;21(3):499-515. Epub 2017 May 18 doi: 10.1016/j.cld.2017.03.006. PMID: 28689589

Recent clinical studies

Etiology

Abu-Ismail L, Taha MJJ, Abuawwad MT, Al-Bustanji Y, Al-Shami K, Nashwan A, Yassin M
Hemoglobin 2023 May;47(3):122-129. Epub 2023 Jul 31 doi: 10.1080/03630269.2023.2236546. PMID: 37519257
Matthews A, Pratz KW
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):23-29. doi: 10.1182/hematology.2022000324. PMID: 36485116Free PMC Article
Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, Picken MM, Herrera GA, Kastritis E, Merlini G, Roussel M, Fervenza FC, Dispenzieri A, Kyle RA, Nasr SH; International Kidney and Monoclonal Gammopathy Research Group
Kidney Int 2015 Apr;87(4):698-711. Epub 2015 Jan 21 doi: 10.1038/ki.2014.408. PMID: 25607108
Raheja D, Specht C, Simmons Z
Muscle Nerve 2015 Jan;51(1):1-13. Epub 2014 Nov 22 doi: 10.1002/mus.24471. PMID: 25288371
Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA; International Kidney and Monoclonal Gammopathy Research Group
Blood 2012 Nov 22;120(22):4292-5. Epub 2012 Oct 9 doi: 10.1182/blood-2012-07-445304. PMID: 23047823

Diagnosis

Shimano KA, Rothman JA, Allen SW, Castillo P, de Jong JLO, Dror Y, Geddis AE, Lau BW, McGuinn C, Narla A, Overholt K, Pereda MA, Sharathkumar A, Sasa G, Nakano TA, Myers K, Gloude NJ, Broglie L, Boklan J
Pediatr Blood Cancer 2024 Aug;71(8):e31070. Epub 2024 May 16 doi: 10.1002/pbc.31070. PMID: 38757488
Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, Picken MM, Herrera GA, Kastritis E, Merlini G, Roussel M, Fervenza FC, Dispenzieri A, Kyle RA, Nasr SH; International Kidney and Monoclonal Gammopathy Research Group
Kidney Int 2015 Apr;87(4):698-711. Epub 2015 Jan 21 doi: 10.1038/ki.2014.408. PMID: 25607108
Raheja D, Specht C, Simmons Z
Muscle Nerve 2015 Jan;51(1):1-13. Epub 2014 Nov 22 doi: 10.1002/mus.24471. PMID: 25288371
Kistangari G, McCrae KR
Hematol Oncol Clin North Am 2013 Jun;27(3):495-520. doi: 10.1016/j.hoc.2013.03.001. PMID: 23714309Free PMC Article
Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA; International Kidney and Monoclonal Gammopathy Research Group
Blood 2012 Nov 22;120(22):4292-5. Epub 2012 Oct 9 doi: 10.1182/blood-2012-07-445304. PMID: 23047823

Therapy

Matthews A, Pratz KW
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):23-29. doi: 10.1182/hematology.2022000324. PMID: 36485116Free PMC Article
Ciftciler R, Haznedaroglu IC
Eur Rev Med Pharmacol Sci 2021 Dec;25(24):7787-7798. doi: 10.26355/eurrev_202112_27625. PMID: 34982440
Roboz GJ, DiNardo CD, Stein EM, de Botton S, Mims AS, Prince GT, Altman JK, Arellano ML, Donnellan W, Erba HP, Mannis GN, Pollyea DA, Stein AS, Uy GL, Watts JM, Fathi AT, Kantarjian HM, Tallman MS, Choe S, Dai D, Fan B, Wang H, Zhang V, Yen KE, Kapsalis SM, Hickman D, Liu H, Agresta SV, Wu B, Attar EC, Stone RM
Blood 2020 Feb 13;135(7):463-471. doi: 10.1182/blood.2019002140. PMID: 31841594Free PMC Article
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA; International Kidney and Monoclonal Gammopathy Research Group
Blood 2012 Nov 22;120(22):4292-5. Epub 2012 Oct 9 doi: 10.1182/blood-2012-07-445304. PMID: 23047823

Prognosis

Abu-Ismail L, Taha MJJ, Abuawwad MT, Al-Bustanji Y, Al-Shami K, Nashwan A, Yassin M
Hemoglobin 2023 May;47(3):122-129. Epub 2023 Jul 31 doi: 10.1080/03630269.2023.2236546. PMID: 37519257
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Swiecicki PL, Hegerova LT, Gertz MA
Blood 2013 Aug 15;122(7):1114-21. Epub 2013 Jun 11 doi: 10.1182/blood-2013-02-474437. PMID: 23757733
Li X, Hou M
Expert Opin Emerg Drugs 2008 Jun;13(2):237-54. doi: 10.1517/14728214.13.2.237. PMID: 18537519
Scaradavou A
Blood Rev 2002 Mar;16(1):73-6. doi: 10.1054/blre.2001.0188. PMID: 11914001

Clinical prediction guides

Pierson SK, Lim MS, Srkalovic G, Brandstadter JD, Sarmiento Bustamante M, Shyamsundar S, Mango N, Lavery C, Austin B, Alapat D, Lechowicz MJ, Bagg A, Li H, Casper C, van Rhee F, Fajgenbaum DC
Blood Adv 2023 Nov 14;7(21):6652-6664. doi: 10.1182/bloodadvances.2023010745. PMID: 37656441Free PMC Article
Abu-Ismail L, Taha MJJ, Abuawwad MT, Al-Bustanji Y, Al-Shami K, Nashwan A, Yassin M
Hemoglobin 2023 May;47(3):122-129. Epub 2023 Jul 31 doi: 10.1080/03630269.2023.2236546. PMID: 37519257
Lee E, Kang MK, Moon G, Gu MJ
Medicina (Kaunas) 2022 Dec 29;59(1) doi: 10.3390/medicina59010077. PMID: 36676701Free PMC Article
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Zaccaria A, Alimena G, Baccarani M, Billström R, Carbonell F, Castoldi GL, Fuscaldo K, Hecht F, Hossfeld DK, Mitelman F
Cancer Genet Cytogenet 1987 May;26(1):65-74. doi: 10.1016/0165-4608(87)90134-8. PMID: 3828975

Recent systematic reviews

Belachew A, Tewabe T
Syst Rev 2020 Feb 12;9(1):31. doi: 10.1186/s13643-020-01289-7. PMID: 32051034Free PMC Article
Hartman EAR, van Royen-Kerkhof A, Jacobs JWG, Welsing PMJ, Fritsch-Stork RDE
Autoimmun Rev 2018 Mar;17(3):316-322. Epub 2018 Jan 31 doi: 10.1016/j.autrev.2018.01.007. PMID: 29366725
Zuo KJ, Fung E, Tredget EE, Lin AN
J Plast Reconstr Aesthet Surg 2015 Mar;68(3):295-303. Epub 2014 Dec 29 doi: 10.1016/j.bjps.2014.12.036. PMID: 25589459
Martí-Carvajal AJ, Peña-Martí GE, Comunián-Carrasco G
Cochrane Database Syst Rev 2009 Oct 7;2009(4):CD007722. doi: 10.1002/14651858.CD007722.pub2. PMID: 19821437Free PMC Article

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