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Breast Inflammatory Myofibroblastic Tumor

MedGen UID:
267767
•Concept ID:
C1511315
•
Neoplastic Process

Definition

A multinodular intermediate fibroblastic neoplasm arising from the breast. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Inflammatory Myofibroblastic Tumor

Professional guidelines

PubMed

Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study.
Liu X, Gong C, Zhang J, Feng W, Guo Y, Sang Y, Wang C, Chen Y, Wang J, Yu L, Zhang X, Luo Z
Cancer Res Treat 2023 Jul;55(3):1001-1010. Epub 2023 Mar 3 doi: 10.4143/crt.2022.894. PMID: 36915248Free PMC Article
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661

Recent clinical studies

Etiology

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer.
Croizer H, Mhaidly R, Kieffer Y, Gentric G, Djerroudi L, Leclere R, Pelon F, Robley C, Bohec M, Meng A, Meseure D, Romano E, Baulande S, Peltier A, Vincent-Salomon A, Mechta-Grigoriou F
Nat Commun 2024 Apr 1;15(1):2806. doi: 10.1038/s41467-024-47068-z. PMID: 38561380Free PMC Article
Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study.
Liu X, Gong C, Zhang J, Feng W, Guo Y, Sang Y, Wang C, Chen Y, Wang J, Yu L, Zhang X, Luo Z
Cancer Res Treat 2023 Jul;55(3):1001-1010. Epub 2023 Mar 3 doi: 10.4143/crt.2022.894. PMID: 36915248Free PMC Article
Clinicopathological Features of Inflammatory Myofibroblastic Tumor in the Breast.
Liu S, Yuan R, Jin Y, He C, Zheng X, Zhan Y
Breast J 2022;2022:1863123. Epub 2022 Aug 12 doi: 10.1155/2022/1863123. PMID: 36304484Free PMC Article
Inflammatory Pseudotumor of the Breast.
Greenleaf EK, Williams NC, Leung AM
Am Surg 2016 May;82(5):e106-7. PMID: 27215709
Inflammatory pseudotumor (myoblastic tumor) of the breast: a case report and review of the literature.
Park SB, Kim HH, Shin HJ, Gong G
J Clin Ultrasound 2010 Jan;38(1):52-5. doi: 10.1002/jcu.20637. PMID: 19802887

Diagnosis

Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
IgG4-related disease.
Hirabayashi K, Zamboni G
Pathologica 2012 Apr;104(2):43-55. PMID: 22953500
Inflammatory pseudotumor of the breast: a mimic of breast carcinoma.
Hill PA
Breast J 2010 Sep-Oct;16(5):549-50. Epub 2010 Aug 4 doi: 10.1111/j.1524-4741.2010.00967.x. PMID: 20701606
Inflammatory pseudotumor (myoblastic tumor) of the breast: a case report and review of the literature.
Park SB, Kim HH, Shin HJ, Gong G
J Clin Ultrasound 2010 Jan;38(1):52-5. doi: 10.1002/jcu.20637. PMID: 19802887

Therapy

Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study.
Liu X, Gong C, Zhang J, Feng W, Guo Y, Sang Y, Wang C, Chen Y, Wang J, Yu L, Zhang X, Luo Z
Cancer Res Treat 2023 Jul;55(3):1001-1010. Epub 2023 Mar 3 doi: 10.4143/crt.2022.894. PMID: 36915248Free PMC Article
Impact of ALK Inhibitors in Patients With ALK-Rearranged Nonlung Solid Tumors.
Takeyasu Y, Okuma HS, Kojima Y, Nishikawa T, Tanioka M, Sudo K, Shimoi T, Noguchi E, Arakawa A, Mori T, Sunami K, Kubo T, Kohno T, Akihiko Y, Yamamoto N, Yonemori K
JCO Precis Oncol 2021;5 Epub 2021 May 3 doi: 10.1200/PO.20.00383. PMID: 34036223Free PMC Article
ALK-positive Histiocytosis of the Breast: A Clinicopathologic Study Highlighting Spindle Cell Histology.
Kashima J, Yoshida M, Jimbo K, Izutsu K, Ushiku T, Yonemori K, Yoshida A
Am J Surg Pathol 2021 Mar 1;45(3):347-355. doi: 10.1097/PAS.0000000000001567. PMID: 32826530
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors.
Tothova Z, Wagner AJ
Curr Opin Oncol 2012 Jul;24(4):409-13. doi: 10.1097/CCO.0b013e328354c155. PMID: 22664824

Prognosis

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer.
Croizer H, Mhaidly R, Kieffer Y, Gentric G, Djerroudi L, Leclere R, Pelon F, Robley C, Bohec M, Meng A, Meseure D, Romano E, Baulande S, Peltier A, Vincent-Salomon A, Mechta-Grigoriou F
Nat Commun 2024 Apr 1;15(1):2806. doi: 10.1038/s41467-024-47068-z. PMID: 38561380Free PMC Article
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Inflammatory Pseudotumor of the Breast.
Greenleaf EK, Williams NC, Leung AM
Am Surg 2016 May;82(5):e106-7. PMID: 27215709
Mesenchymal tumors and tumor-like lesions of the breast: a contemporary approach review.
Stolnicu S, Moldovan C, Podoleanu C, Georgescu R
Ann Pathol 2015 Jan;35(1):15-31. Epub 2014 Dec 20 doi: 10.1016/j.annpat.2014.10.001. PMID: 25533916
Inflammatory pseudotumor (myoblastic tumor) of the breast: a case report and review of the literature.
Park SB, Kim HH, Shin HJ, Gong G
J Clin Ultrasound 2010 Jan;38(1):52-5. doi: 10.1002/jcu.20637. PMID: 19802887

Clinical prediction guides

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer.
Croizer H, Mhaidly R, Kieffer Y, Gentric G, Djerroudi L, Leclere R, Pelon F, Robley C, Bohec M, Meng A, Meseure D, Romano E, Baulande S, Peltier A, Vincent-Salomon A, Mechta-Grigoriou F
Nat Commun 2024 Apr 1;15(1):2806. doi: 10.1038/s41467-024-47068-z. PMID: 38561380Free PMC Article
Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts.
Andreucci E, Fioretto BS, Rosa I, Matucci-Cerinic M, Biagioni A, Romano E, Calorini L, Manetti M
Cells 2023 Mar 20;12(6) doi: 10.3390/cells12060939. PMID: 36980280Free PMC Article
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Inflammatory myofibroblastic tumour (inflammatory pseudotumour) of the breast. Clinicopathological and genetic analysis of a case with evidence for clonality.
Sastre-Garau X, Couturier J, Derré J, Aurias A, Klijanienko J, Lagacé R
J Pathol 2002 Jan;196(1):97-102. doi: 10.1002/path.1004. PMID: 11748648

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