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Breast Carcinoma Metastatic in the Lung

MedGen UID:
231964
•Concept ID:
C1332626
•
Neoplastic Process
Synonym: Breast Carcinoma Metastatic to the Lung

Definition

A carcinoma that arises from the breast and has metastasized to the lung. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Carcinoma Metastatic in the Lung

Professional guidelines

PubMed

Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation.
Mousset A, Lecorgne E, Bourget I, Lopez P, Jenovai K, Cherfils-Vicini J, Dominici C, Rios G, Girard-Riboulleau C, Liu B, Spector DL, Ehmsen S, Renault S, Hego C, Mechta-Grigoriou F, Bidard FC, Terp MG, Egeblad M, Gaggioli C, Albrengues J
Cancer Cell 2023 Apr 10;41(4):757-775.e10. doi: 10.1016/j.ccell.2023.03.008. PMID: 37037615Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Lymphoma: Diagnosis and Treatment.
Lewis WD, Lilly S, Jones KL
Am Fam Physician 2020 Jan 1;101(1):34-41. PMID: 31894937

Recent clinical studies

Etiology

Standard-of-care systemic therapy with or without stereotactic body radiotherapy in patients with oligoprogressive breast cancer or non-small-cell lung cancer (Consolidative Use of Radiotherapy to Block [CURB] oligoprogression): an open-label, randomised, controlled, phase 2 study.
Tsai CJ, Yang JT, Shaverdian N, Patel J, Shepherd AF, Eng J, Guttmann D, Yeh R, Gelblum DY, Namakydoust A, Preeshagul I, Modi S, Seidman A, Traina T, Drullinsky P, Flynn J, Zhang Z, Rimner A, Gillespie EF, Gomez DR, Lee NY, Berger M, Robson ME, Reis-Filho JS, Riaz N, Rudin CM, Powell SN; CURB Study Group
Lancet 2024 Jan 13;403(10422):171-182. Epub 2023 Dec 14 doi: 10.1016/S0140-6736(23)01857-3. PMID: 38104577Free PMC Article
Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis.
Pan J, Zhang L, Wang X, Li L, Yang C, Wang Z, Su K, Hu X, Zhang Y, Ren G, Jiang J, Li P, Huang J
J Exp Clin Cancer Res 2023 Sep 29;42(1):255. doi: 10.1186/s13046-023-02836-5. PMID: 37773152Free PMC Article
Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung.
Tyagi A, Sharma S, Wu K, Wu SY, Xing F, Liu Y, Zhao D, Deshpande RP, D'Agostino RB Jr, Watabe K
Nat Commun 2021 Jan 20;12(1):474. doi: 10.1038/s41467-020-20733-9. PMID: 33473115Free PMC Article
Oligometastatic breast cancer.
Kwapisz D
Breast Cancer 2019 Mar;26(2):138-146. Epub 2018 Oct 15 doi: 10.1007/s12282-018-0921-1. PMID: 30324552
Metastatic behavior of breast cancer subtypes.
Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K
J Clin Oncol 2010 Jul 10;28(20):3271-7. Epub 2010 May 24 doi: 10.1200/JCO.2009.25.9820. PMID: 20498394

Diagnosis

Case 17-2024: A 45-Year-Old Woman with Metastatic Breast Cancer.
Vidula N, Rodriguez K, Wong AK, Boyraz B
N Engl J Med 2024 Jun 6;390(21):2011-2022. doi: 10.1056/NEJMcpc2309499. PMID: 38838315
Organ-Specificity of Breast Cancer Metastasis.
Ibragimova MK, Tsyganov MM, Kravtsova EA, Tsydenova IA, Litviakov NV
Int J Mol Sci 2023 Oct 26;24(21) doi: 10.3390/ijms242115625. PMID: 37958607Free PMC Article
Pathologic differential diagnosis of metastatic carcinoma in the liver.
Park JH, Kim JH
Clin Mol Hepatol 2019 Mar;25(1):12-20. Epub 2018 Oct 5 doi: 10.3350/cmh.2018.0067. PMID: 30300991Free PMC Article
Neuroendocrine Tumors of the Breast.
Rosen LE, Gattuso P
Arch Pathol Lab Med 2017 Nov;141(11):1577-1581. doi: 10.5858/arpa.2016-0364-RS. PMID: 29072945
Sarcoidosis presenting as metastatic lymphadenopathy in breast cancer.
Akhtari M, Quesada JR, Schwartz MR, Chiang SB, Teh BS
Clin Breast Cancer 2014 Oct;14(5):e107-10. Epub 2014 Jun 2 doi: 10.1016/j.clbc.2014.05.001. PMID: 25017468

Therapy

Antibody-drug conjugates in lung and breast cancer: current evidence and future directions-a position statement from the ETOP IBCSG Partners Foundation.
Peters S, Loi S, André F, Chandarlapaty S, Felip E, Finn SP, Jänne PA, Kerr KM, Munzone E, Passaro A, Pérol M, Smit EF, Swanton C, Viale G, Stahel RA
Ann Oncol 2024 Jul;35(7):607-629. Epub 2024 Apr 20 doi: 10.1016/j.annonc.2024.04.002. PMID: 38648979
Clinical management, monitoring, and prophylaxis of adverse events of special interest associated with datopotamab deruxtecan.
Heist RS, Sands J, Bardia A, Shimizu T, Lisberg A, Krop I, Yamamoto N, Kogawa T, Al-Hashimi S, Fung SSM, Galor A, Pisetzky F, Basak P, Lau C, Meric-Bernstam F
Cancer Treat Rev 2024 Apr;125:102720. Epub 2024 Mar 11 doi: 10.1016/j.ctrv.2024.102720. PMID: 38502995
Standard-of-care systemic therapy with or without stereotactic body radiotherapy in patients with oligoprogressive breast cancer or non-small-cell lung cancer (Consolidative Use of Radiotherapy to Block [CURB] oligoprogression): an open-label, randomised, controlled, phase 2 study.
Tsai CJ, Yang JT, Shaverdian N, Patel J, Shepherd AF, Eng J, Guttmann D, Yeh R, Gelblum DY, Namakydoust A, Preeshagul I, Modi S, Seidman A, Traina T, Drullinsky P, Flynn J, Zhang Z, Rimner A, Gillespie EF, Gomez DR, Lee NY, Berger M, Robson ME, Reis-Filho JS, Riaz N, Rudin CM, Powell SN; CURB Study Group
Lancet 2024 Jan 13;403(10422):171-182. Epub 2023 Dec 14 doi: 10.1016/S0140-6736(23)01857-3. PMID: 38104577Free PMC Article
Trastuzumab deruxtecan for HER2+ advanced breast cancer.
Lee J, Park YH
Future Oncol 2022 Jan;18(1):7-19. Epub 2021 Nov 26 doi: 10.2217/fon-2021-0550. PMID: 34823373
Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung.
Tyagi A, Sharma S, Wu K, Wu SY, Xing F, Liu Y, Zhao D, Deshpande RP, D'Agostino RB Jr, Watabe K
Nat Commun 2021 Jan 20;12(1):474. doi: 10.1038/s41467-020-20733-9. PMID: 33473115Free PMC Article

Prognosis

Organ-Specificity of Breast Cancer Metastasis.
Ibragimova MK, Tsyganov MM, Kravtsova EA, Tsydenova IA, Litviakov NV
Int J Mol Sci 2023 Oct 26;24(21) doi: 10.3390/ijms242115625. PMID: 37958607Free PMC Article
Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung.
Tyagi A, Sharma S, Wu K, Wu SY, Xing F, Liu Y, Zhao D, Deshpande RP, D'Agostino RB Jr, Watabe K
Nat Commun 2021 Jan 20;12(1):474. doi: 10.1038/s41467-020-20733-9. PMID: 33473115Free PMC Article
Association of Menopausal Hormone Therapy With Breast Cancer Incidence and Mortality During Long-term Follow-up of the Women's Health Initiative Randomized Clinical Trials.
Chlebowski RT, Anderson GL, Aragaki AK, Manson JE, Stefanick ML, Pan K, Barrington W, Kuller LH, Simon MS, Lane D, Johnson KC, Rohan TE, Gass MLS, Cauley JA, Paskett ED, Sattari M, Prentice RL
JAMA 2020 Jul 28;324(4):369-380. doi: 10.1001/jama.2020.9482. PMID: 32721007Free PMC Article
Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer.
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Epidemiology of brain metastases.
Nayak L, Lee EQ, Wen PY
Curr Oncol Rep 2012 Feb;14(1):48-54. doi: 10.1007/s11912-011-0203-y. PMID: 22012633

Clinical prediction guides

The temporal progression of lung immune remodeling during breast cancer metastasis.
McGinnis CS, Miao Z, Superville D, Yao W, Goga A, Reticker-Flynn NE, Winkler J, Satpathy AT
Cancer Cell 2024 Jun 10;42(6):1018-1031.e6. Epub 2024 May 30 doi: 10.1016/j.ccell.2024.05.004. PMID: 38821060Free PMC Article
Standard-of-care systemic therapy with or without stereotactic body radiotherapy in patients with oligoprogressive breast cancer or non-small-cell lung cancer (Consolidative Use of Radiotherapy to Block [CURB] oligoprogression): an open-label, randomised, controlled, phase 2 study.
Tsai CJ, Yang JT, Shaverdian N, Patel J, Shepherd AF, Eng J, Guttmann D, Yeh R, Gelblum DY, Namakydoust A, Preeshagul I, Modi S, Seidman A, Traina T, Drullinsky P, Flynn J, Zhang Z, Rimner A, Gillespie EF, Gomez DR, Lee NY, Berger M, Robson ME, Reis-Filho JS, Riaz N, Rudin CM, Powell SN; CURB Study Group
Lancet 2024 Jan 13;403(10422):171-182. Epub 2023 Dec 14 doi: 10.1016/S0140-6736(23)01857-3. PMID: 38104577Free PMC Article
Molecular Mechanisms of Breast Cancer Metastasis to the Lung: Clinical and Experimental Perspectives.
Medeiros B, Allan AL
Int J Mol Sci 2019 May 8;20(9) doi: 10.3390/ijms20092272. PMID: 31071959Free PMC Article
Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps.
Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, Schott AF, Kinugasa-Katayama Y, Lee Y, Won NH, Nakasone ES, Hearn SA, Küttner V, Qiu J, Almeida AS, Perurena N, Kessenbrock K, Goldberg MS, Egeblad M
Sci Transl Med 2016 Oct 19;8(361):361ra138. doi: 10.1126/scitranslmed.aag1711. PMID: 27798263Free PMC Article
Metastatic behavior of breast cancer subtypes.
Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K
J Clin Oncol 2010 Jul 10;28(20):3271-7. Epub 2010 May 24 doi: 10.1200/JCO.2009.25.9820. PMID: 20498394

Recent systematic reviews

Incidence of interstitial lung disease and cardiotoxicity with trastuzumab deruxtecan in breast cancer patients: a systematic review and single-arm meta-analysis.
Soares LR, Vilbert M, Rosa VDL, Oliveira JL, Deus MM, Freitas-Junior R
ESMO Open 2023 Aug;8(4):101613. Epub 2023 Jul 23 doi: 10.1016/j.esmoop.2023.101613. PMID: 37481956Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Telephone interventions for symptom management in adults with cancer.
Ream E, Hughes AE, Cox A, Skarparis K, Richardson A, Pedersen VH, Wiseman T, Forbes A, Bryant A
Cochrane Database Syst Rev 2020 Jun 2;6(6):CD007568. doi: 10.1002/14651858.CD007568.pub2. PMID: 32483832Free PMC Article
Green tea (Camellia sinensis) for the prevention of cancer.
Filippini T, Malavolti M, Borrelli F, Izzo AA, Fairweather-Tait SJ, Horneber M, Vinceti M
Cochrane Database Syst Rev 2020 Mar 2;3(3):CD005004. doi: 10.1002/14651858.CD005004.pub3. PMID: 32118296Free PMC Article
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J
Cochrane Database Syst Rev 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. PMID: 28093732Free PMC Article

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