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Breast Tall Cell Carcinoma with Reversed Polarity

MedGen UID:
1784377
•Concept ID:
C5446657
•
Neoplastic Process

Definition

A rare subtype of invasive breast carcinoma characterized by tall columnar cells with reversed nuclear polarity, arranged in solid and solid papillary patterns, most commonly associated with IDH2 p.Arg172 hotspot mutations. (WHO 2019) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Tall Cell Carcinoma with Reversed Polarity

Professional guidelines

PubMed

Triple-negative breast carcinomas of low malignant potential: review on diagnostic criteria and differential diagnoses.
Cima L, Kaya H, Marchiò C, Nishimura R, Wen HY, Fabbri VP, Foschini MP
Virchows Arch 2022 Jan;480(1):109-126. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03174-7. PMID: 34458945Free PMC Article
Genotype-phenotype associations in breast pathology: Achievements of the past quarter century.
Muller KE, Marotti JD
Breast J 2020 Jun;26(6):1123-1131. Epub 2020 May 4 doi: 10.1111/tbj.13861. PMID: 32367572

Recent clinical studies

Etiology

Recurrent IDH2 Mutations in Salivary Gland Striated Duct Adenoma Define an Expanded Histologic Spectrum Distinct From Canalicular Adenoma.
Rooper LM, Agaimy A, Assaad A, Bal M, Eugene H, Gagan J, Nonogaki H, Palsgrove DN, Shah A, Stelow E, Stoehr R, Thompson LDR, Weinreb I, Bishop JA
Am J Surg Pathol 2023 Mar 1;47(3):333-343. Epub 2022 Dec 13 doi: 10.1097/PAS.0000000000002004. PMID: 36510691
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features.
Jassim M, Premalata CS, Okaly G, Srinivas C
Turk Patoloji Derg 2021;37(2):183-188. doi: 10.5146/tjpath.2020.01511. PMID: 33021737Free PMC Article
Invasive breast cancer: Current perspectives and emerging views.
Shea EKH, Koh VCY, Tan PH
Pathol Int 2020 May;70(5):242-252. Epub 2020 Feb 10 doi: 10.1111/pin.12910. PMID: 32039524
Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (solid papillary carcinomas with reverse polarity) harbour recurrent mutations affecting IDH2 and PIK3CA: a validation cohort.
Lozada JR, Basili T, Pareja F, Alemar B, Paula ADC, Gularte-Merida R, Giri DD, Querzoli P, Cserni G, Rakha EA, Foschini MP, Reis-Filho JS, Brogi E, Weigelt B, Geyer FC
Histopathology 2018 Aug;73(2):339-344. Epub 2018 Jun 1 doi: 10.1111/his.13522. PMID: 29603332Free PMC Article

Diagnosis

Tall cell carcinoma of the breast with reversed polarity - a report of three cases with a review of the literature.
Kajo K, Ducár M, Dzuracký J, Macháleková KK, Vallová M, Biró C, Šebest L, Slamka T, Lohajová RB, Žúbor P
Cesk Patol 2023;59(3):132-138. PMID: 38756088
The Diagnostic Utility of IDH2 R172 Immunohistochemistry in Tall Cell Carcinoma With Reversed Polarity of the Breast.
Sasaki E, Iwakoshi A, Satake T, Nakajima K, Kobayashi M, Ando Y, Koshikawa T, Masago K, Honma N, Nishimura R, Kato Y, Ichihara S
Appl Immunohistochem Mol Morphol 2022 Nov-Dec 01;30(10):654-661. Epub 2022 Oct 12 doi: 10.1097/PAI.0000000000001074. PMID: 36222504
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367
Novel uses of immunohistochemistry in breast pathology: interpretation and pitfalls.
Cimino-Mathews A
Mod Pathol 2021 Jan;34(Suppl 1):62-77. Epub 2020 Oct 27 doi: 10.1038/s41379-020-00697-3. PMID: 33110239

Therapy

Imprint Cytology of Tall Cell Carcinoma with Reversed Polarity of the Breast: A Case Report.
Shinomiya Y, Kouchi Y, Onodera K, Yamamoto H, Harada-Kagitani S, Sakakibara J, Nagashima T, Ikeda JI, Kishimoto T
Acta Cytol 2024;68(1):73-79. Epub 2024 Jan 23 doi: 10.1159/000536346. PMID: 38262369
Breast Tumor Resembling the Tall Cell Variant of Papillary Thyroid Carcinoma: Molecular Characterization by Next-Generation Sequencing and Histopathological Comparison With Tall Cell Papillary Carcinoma of Thyroid.
Zhong E, Scognamiglio T, D'Alfonso T, Song W, Tran H, Baek I, Hoda SA
Int J Surg Pathol 2019 Apr;27(2):134-141. Epub 2018 Sep 18 doi: 10.1177/1066896918800779. PMID: 30227763

Prognosis

A new subtype of papillary ductal carcinoma in situ with tall cell and reversed polarity morphology: a rare case report.
Zhong R, Chang Z, Wang X, Zhong D
BMC Womens Health 2024 Dec 19;24(1):640. doi: 10.1186/s12905-024-03489-y. PMID: 39702261Free PMC Article
Triple-negative breast carcinomas of low malignant potential: review on diagnostic criteria and differential diagnoses.
Cima L, Kaya H, Marchiò C, Nishimura R, Wen HY, Fabbri VP, Foschini MP
Virchows Arch 2022 Jan;480(1):109-126. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03174-7. PMID: 34458945Free PMC Article
Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367
Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features.
Jassim M, Premalata CS, Okaly G, Srinivas C
Turk Patoloji Derg 2021;37(2):183-188. doi: 10.5146/tjpath.2020.01511. PMID: 33021737Free PMC Article
Invasive breast cancer: Current perspectives and emerging views.
Shea EKH, Koh VCY, Tan PH
Pathol Int 2020 May;70(5):242-252. Epub 2020 Feb 10 doi: 10.1111/pin.12910. PMID: 32039524

Clinical prediction guides

Imprint Cytology of Tall Cell Carcinoma with Reversed Polarity of the Breast: A Case Report.
Shinomiya Y, Kouchi Y, Onodera K, Yamamoto H, Harada-Kagitani S, Sakakibara J, Nagashima T, Ikeda JI, Kishimoto T
Acta Cytol 2024;68(1):73-79. Epub 2024 Jan 23 doi: 10.1159/000536346. PMID: 38262369
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features.
Jassim M, Premalata CS, Okaly G, Srinivas C
Turk Patoloji Derg 2021;37(2):183-188. doi: 10.5146/tjpath.2020.01511. PMID: 33021737Free PMC Article
Invasive breast cancer: Current perspectives and emerging views.
Shea EKH, Koh VCY, Tan PH
Pathol Int 2020 May;70(5):242-252. Epub 2020 Feb 10 doi: 10.1111/pin.12910. PMID: 32039524
Solid papillary carcinoma with reverse polarity of the breast harbors specific morphologic, immunohistochemical and molecular profile in comparison with other benign or malignant papillary lesions of the breast: a comparative study of 9 additional cases.
Alsadoun N, MacGrogan G, Truntzer C, Lacroix-Triki M, Bedgedjian I, Koeb MH, El Alam E, Medioni D, Parent M, Wuithier P, Robert I, Boidot R, Arnould L
Mod Pathol 2018 Sep;31(9):1367-1380. Epub 2018 May 21 doi: 10.1038/s41379-018-0047-1. PMID: 29785016

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