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Adult Acute Myeloid Leukemia

MedGen UID:
113092
•Concept ID:
C0220615
•
Neoplastic Process
Synonyms: Adult Acute Myeloblastic Leukemia; Adult Acute Myelogenous Leukemia; Adult Acute Non-Lymphoblastic Leukemia; Adult Acute NonLymphoblastic Leukemia; Adult AML; Adult ANLL

Definition

An acute myeloid leukemia occurring in adults. [from NCI]

Professional guidelines

PubMed

Outcome of adult acute myeloid leukemia patients with extramedullary disease and treatment with venetoclax/ hypomethylating agents.
Kayser S, Sanber K, Marconi G, Mattei A, Luskin MR, Kelkar A, Cerrano M, Kristensen DT, Roug AS, Sartor C, Giglio F, Riva M, Rizzo L, Saraceni F, Guerzoni S, Lessi F, Borlenghi E, Levis MJ, Schlenk RF, Jain T, Papayannidis C
Haematologica 2025 Feb 1;110(2):378-384. doi: 10.3324/haematol.2024.285985. PMID: 39363862Free PMC Article
Exploitation of natural killer cells for the treatment of acute leukemia.
Handgretinger R, Lang P, André MC
Blood 2016 Jun 30;127(26):3341-9. Epub 2016 May 20 doi: 10.1182/blood-2015-12-629055. PMID: 27207791
Going beyond 7 + 3 regimens in the treatment of adult acute myeloid leukemia.
Tefferi A, Letendre L
J Clin Oncol 2012 Jul 10;30(20):2425-8. Epub 2012 Apr 23 doi: 10.1200/JCO.2011.38.9601. PMID: 22529263

Recent clinical studies

Etiology

Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors.
Barajas JM, Rasouli M, Umeda M, Hiltenbrand R, Abdelhamed S, Mohnani R, Arthur B, Westover T, Thomas ME 3rd, Ashtiani M, Janke LJ, Xu B, Chang TC, Rosikiewicz W, Xiong E, Rolle C, Low J, Krishan R, Song G, Walsh MP, Ma J, Rubnitz JE, Iacobucci I, Chen T, Krippner-Heidenreich A, Zwaan CM, Heidenreich O, Klco JM
Blood 2024 Feb 15;143(7):619-630. doi: 10.1182/blood.2023021359. PMID: 37890156Free PMC Article
How I diagnose and treat NPM1-mutated AML.
Falini B, Brunetti L, Martelli MP
Blood 2021 Feb 4;137(5):589-599. doi: 10.1182/blood.2020008211. PMID: 33171486
NPM1-mutated acute myeloid leukemia: from bench to bedside.
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Treatment of adult acute myeloid leukemia.
Järvenpää J, Itälä-Remes M, Kauko T, Salmenniemi U, Kauppila M, Putkonen M, Salmi T, Remes K
Duodecim 2016;132(16):1465-73. PMID: 29188934
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520

Diagnosis

Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors.
Barajas JM, Rasouli M, Umeda M, Hiltenbrand R, Abdelhamed S, Mohnani R, Arthur B, Westover T, Thomas ME 3rd, Ashtiani M, Janke LJ, Xu B, Chang TC, Rosikiewicz W, Xiong E, Rolle C, Low J, Krishan R, Song G, Walsh MP, Ma J, Rubnitz JE, Iacobucci I, Chen T, Krippner-Heidenreich A, Zwaan CM, Heidenreich O, Klco JM
Blood 2024 Feb 15;143(7):619-630. doi: 10.1182/blood.2023021359. PMID: 37890156Free PMC Article
Role of Measurable Residual Disease in Older Adult Acute Myeloid Leukemia.
Li X, Tong X
Clin Interv Aging 2023;18:921-931. Epub 2023 Jun 7 doi: 10.2147/CIA.S409308. PMID: 37313310Free PMC Article
How I diagnose and treat NPM1-mutated AML.
Falini B, Brunetti L, Martelli MP
Blood 2021 Feb 4;137(5):589-599. doi: 10.1182/blood.2020008211. PMID: 33171486
NPM1-mutated acute myeloid leukemia: from bench to bedside.
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Venetoclax-based therapies for acute myeloid leukemia.
Guerra VA, DiNardo C, Konopleva M
Best Pract Res Clin Haematol 2019 Jun;32(2):145-153. Epub 2019 May 24 doi: 10.1016/j.beha.2019.05.008. PMID: 31203996Free PMC Article

Therapy

Venetoclax in adult acute myeloid leukemia.
Hu M, Li W, Zhang Y, Liang C, Tan J, Wang Y
Biomed Pharmacother 2023 Dec;168:115820. Epub 2023 Nov 6 doi: 10.1016/j.biopha.2023.115820. PMID: 37925935
How I diagnose and treat NPM1-mutated AML.
Falini B, Brunetti L, Martelli MP
Blood 2021 Feb 4;137(5):589-599. doi: 10.1182/blood.2020008211. PMID: 33171486
Venetoclax-based therapies for acute myeloid leukemia.
Guerra VA, DiNardo C, Konopleva M
Best Pract Res Clin Haematol 2019 Jun;32(2):145-153. Epub 2019 May 24 doi: 10.1016/j.beha.2019.05.008. PMID: 31203996Free PMC Article
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Analogue peptides for the immunotherapy of human acute myeloid leukemia.
Hofmann S, Mead A, Malinovskis A, Hardwick NR, Guinn BA
Cancer Immunol Immunother 2015 Nov;64(11):1357-67. Epub 2015 Oct 5 doi: 10.1007/s00262-015-1762-9. PMID: 26438084Free PMC Article

Prognosis

Venetoclax in adult acute myeloid leukemia.
Hu M, Li W, Zhang Y, Liang C, Tan J, Wang Y
Biomed Pharmacother 2023 Dec;168:115820. Epub 2023 Nov 6 doi: 10.1016/j.biopha.2023.115820. PMID: 37925935
Therapeutic implications of menin inhibition in acute leukemias.
Issa GC, Ravandi F, DiNardo CD, Jabbour E, Kantarjian HM, Andreeff M
Leukemia 2021 Sep;35(9):2482-2495. Epub 2021 Jun 15 doi: 10.1038/s41375-021-01309-y. PMID: 34131281
NPM1-mutated acute myeloid leukemia: from bench to bedside.
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Venetoclax-based therapies for acute myeloid leukemia.
Guerra VA, DiNardo C, Konopleva M
Best Pract Res Clin Haematol 2019 Jun;32(2):145-153. Epub 2019 May 24 doi: 10.1016/j.beha.2019.05.008. PMID: 31203996Free PMC Article
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520

Clinical prediction guides

Venetoclax in adult acute myeloid leukemia.
Hu M, Li W, Zhang Y, Liang C, Tan J, Wang Y
Biomed Pharmacother 2023 Dec;168:115820. Epub 2023 Nov 6 doi: 10.1016/j.biopha.2023.115820. PMID: 37925935
Role of Measurable Residual Disease in Older Adult Acute Myeloid Leukemia.
Li X, Tong X
Clin Interv Aging 2023;18:921-931. Epub 2023 Jun 7 doi: 10.2147/CIA.S409308. PMID: 37313310Free PMC Article
Therapeutic implications of menin inhibition in acute leukemias.
Issa GC, Ravandi F, DiNardo CD, Jabbour E, Kantarjian HM, Andreeff M
Leukemia 2021 Sep;35(9):2482-2495. Epub 2021 Jun 15 doi: 10.1038/s41375-021-01309-y. PMID: 34131281
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Neutropenic fever and severe sepsis in adult acute myeloid leukemia (AML) patients receiving intensive chemotherapy: Causes and consequences.
Hämäläinen S, Kuittinen T, Matinlauri I, Nousiainen T, Koivula I, Jantunen E
Leuk Lymphoma 2008 Mar;49(3):495-501. doi: 10.1080/10428190701809172. PMID: 18297526

Recent systematic reviews

Systematic review and meta-analysis evaluating clinical outcomes in adult acute myeloid leukemia patients with central nervous system involvement.
Goulart H, Sastow D, Moshier E, Martin L, Mascarenhas J, Tremblay D
Leuk Res 2024 Feb;137:107452. Epub 2024 Feb 6 doi: 10.1016/j.leukres.2024.107452. PMID: 38335816
Comparison of early mortality between leukapheresis and non-leukapheresis in adult acute myeloid leukemia patients with hyperleukocytosis: a systematic review and meta-analysis.
Rinaldi I, Sutandyo N, Winston K
Hematology 2022 Dec;27(1):141-149. doi: 10.1080/16078454.2021.2024939. PMID: 35068391
Efficacy and safety of adding gemtuzumab ozogamicin to conventional chemotherapy for adult acute myeloid leukemia: a systematic review and meta-analysis.
Guo Y, Deng L, Qiao Y, Liu B
Hematology 2022 Dec;27(1):53-64. doi: 10.1080/16078454.2021.2013410. PMID: 34957930
Hematopoietic Cell Transplantation in the Treatment of Newly Diagnosed Adult Acute Myeloid Leukemia: An Evidence-Based Review from the American Society of Transplantation and Cellular Therapy.
Dholaria B, Savani BN, Hamilton BK, Oran B, Liu HD, Tallman MS, Ciurea SO, Holtzman NG, Ii GLP, Devine SM, Mannis G, Grunwald MR, Appelbaum F, Rodriguez C, El Chaer F, Shah N, Hashmi SK, Kharfan-Dabaja MA, DeFilipp Z, Aljurf M, AlShaibani A, Inamoto Y, Jain T, Majhail N, Perales MA, Mohty M, Hamadani M, Carpenter PA, Nagler A
Transplant Cell Ther 2021 Jan;27(1):6-20. Epub 2020 Sep 20 doi: 10.1016/j.bbmt.2020.09.020. PMID: 32966881
Efficacy and Toxicity of Idarubicin Versus High-dose Daunorubicin for Induction Chemotherapy in Adult Acute Myeloid Leukemia: A Systematic Review and Meta-analysis.
Owattanapanich W, Owattanapanich N, Kungwankiattichai S, Ungprasert P, Ruchutrakool T
Clin Lymphoma Myeloma Leuk 2018 Dec;18(12):814-821.e3. Epub 2018 Aug 22 doi: 10.1016/j.clml.2018.08.008. PMID: 30241991

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