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Breast Hyperplasia

MedGen UID:
107756
•Concept ID:
C0542028
•
Finding
Synonym: Breast Proliferative Disorder

Definition

A general term that refers to hyperplastic proliferations of the epithelial cells in the breast parenchyma. Examples include atypical ductal hyperplasia, usual ductal hyperplasia, columnar cell hyperplasia, and atypical lobular hyperplasia. [from NCI]

Professional guidelines

PubMed

Guidelines for the clinical application of the Xihuang pill for the prevention and treatment of breast hyperplasia diseases.
Tang H, Lu Q, Feng S, Xiao Z, Wu W, Chen G, Deng L, Yu T, Wu J, Lin H, Ji B, Lin J, Zhang C, Li L, Liu T, Ouyang Y, Lei K, Chen J, Peng W, Qiu Z, Cai Q, Liang Q, Liu C, Li Y, Zhu L, Zhang Z, Liu X, Lin L, Zheng Z
Pharm Biol 2024 Dec;62(1):472-479. Epub 2024 May 20 doi: 10.1080/13880209.2024.2350233. PMID: 38769628Free PMC Article
Massage treatment of hyperplasia of mammary glands: A protocol for a systematic review and meta-analysis.
Ma D, Liu G, Zhang X, Zhang Q, Gao T, Liu M
Medicine (Baltimore) 2020 Dec 24;99(52):e23601. doi: 10.1097/MD.0000000000023601. PMID: 33350735Free PMC Article
Serological thymidine kinase 1 is a biomarker for early detection of tumours--a health screening study on 35,365 people, using a sensitive chemiluminescent dot blot assay.
Chen ZH, Huang SQ, Wang Y, Yang AZ, Wen J, Xu XH, Chen Y, Chen QB, Wang YH, He E, Zhou J, Skog S
Sensors (Basel) 2011;11(12):11064-80. Epub 2011 Nov 28 doi: 10.3390/s111211064. PMID: 22247653Free PMC Article

Recent clinical studies

Etiology

HYPERPLASIA OF THE FEMALE REPRODUCTIVE ORGANS IN UKRAINE.
Salmanov AG, Artyomenko V, Hladenko SY, Koctjuk IM, Marchenko AO, Tolstanova GO, Korniyenko SM
Wiad Lek 2023;76(3):467-473. doi: 10.36740/WLek202303101. PMID: 37057766
Expression and clinical prognostic value of CYB561 in breast cancer.
Zhou X, Shen G, Ren D, Guo X, Han J, Guo Q, Zhao F, Wang M, Dong Q, Li Z, Zhao J
J Cancer Res Clin Oncol 2022 Aug;148(8):1879-1892. Epub 2022 Apr 29 doi: 10.1007/s00432-022-03928-z. PMID: 35486183
Molecular fingerprint of precancerous lesions in breast atypical hyperplasia.
Zheng C, Jia HY, Liu LY, Wang Q, Jiang HC, Teng LS, Geng CZ, Jin F, Tang LL, Zhang JG, Wang X, Wang S, Alejandro FE, Wang F, Yu LX, Zhou F, Xiang YJ, Huang SY, Fu QY, Zhang Q, Gao Z, Ma ZB, Li L, Fan ZM, Yu ZG
J Int Med Res 2020 Jun;48(6):300060520931616. doi: 10.1177/0300060520931616. PMID: 32589079Free PMC Article
Gene expression signature of atypical breast hyperplasia and regulation by SFRP1.
Gregory KJ, Roberts AL, Conlon EM, Mayfield JA, Hagen MJ, Crisi GM, Bentley BA, Kane JJ, Makari-Judson G, Mason HS, Yu J, Zhu LJ, Simin K, Johnson JPS, Khan A, Schneider BR, Schneider SS, Jerry DJ
Breast Cancer Res 2019 Jun 27;21(1):76. doi: 10.1186/s13058-019-1157-5. PMID: 31248446Free PMC Article
Diagnosis of Breast Hyperplasia and Evaluation of RuXian-I Based on Metabolomics Deep Belief Networks.
Jiang M, Liang Y, Pei Z, Wang X, Zhou F, Wei C, Feng X
Int J Mol Sci 2019 May 28;20(11) doi: 10.3390/ijms20112620. PMID: 31141969Free PMC Article

Diagnosis

HYPERPLASIA OF THE FEMALE REPRODUCTIVE ORGANS IN UKRAINE.
Salmanov AG, Artyomenko V, Hladenko SY, Koctjuk IM, Marchenko AO, Tolstanova GO, Korniyenko SM
Wiad Lek 2023;76(3):467-473. doi: 10.36740/WLek202303101. PMID: 37057766
Molecular fingerprint of precancerous lesions in breast atypical hyperplasia.
Zheng C, Jia HY, Liu LY, Wang Q, Jiang HC, Teng LS, Geng CZ, Jin F, Tang LL, Zhang JG, Wang X, Wang S, Alejandro FE, Wang F, Yu LX, Zhou F, Xiang YJ, Huang SY, Fu QY, Zhang Q, Gao Z, Ma ZB, Li L, Fan ZM, Yu ZG
J Int Med Res 2020 Jun;48(6):300060520931616. doi: 10.1177/0300060520931616. PMID: 32589079Free PMC Article
Gene expression signature of atypical breast hyperplasia and regulation by SFRP1.
Gregory KJ, Roberts AL, Conlon EM, Mayfield JA, Hagen MJ, Crisi GM, Bentley BA, Kane JJ, Makari-Judson G, Mason HS, Yu J, Zhu LJ, Simin K, Johnson JPS, Khan A, Schneider BR, Schneider SS, Jerry DJ
Breast Cancer Res 2019 Jun 27;21(1):76. doi: 10.1186/s13058-019-1157-5. PMID: 31248446Free PMC Article
Diagnosis of Breast Hyperplasia and Evaluation of RuXian-I Based on Metabolomics Deep Belief Networks.
Jiang M, Liang Y, Pei Z, Wang X, Zhou F, Wei C, Feng X
Int J Mol Sci 2019 May 28;20(11) doi: 10.3390/ijms20112620. PMID: 31141969Free PMC Article
The Clinical Value of Hepcidin in Breast Cancer and Its Bone Metastasis.
Shao X, Cao F, Tao M
Ann Clin Lab Sci 2017 Mar;47(2):120-128. PMID: 28442512

Therapy

The anti-hyperplasia effect of polysaccharide from Prunella vulgaris L. on mammary gland hyperplasia in rats through regulation of the AKT-FOXO3a signaling pathway and intestinal flora.
Zhao H, Yang Y, Zhou Y, Wen H, Chen C, Li C, Feng Y, Li L, Li X
J Sci Food Agric 2024 Oct;104(13):8190-8200. Epub 2024 Jun 14 doi: 10.1002/jsfa.13652. PMID: 38872513
Guidelines for the clinical application of the Xihuang pill for the prevention and treatment of breast hyperplasia diseases.
Tang H, Lu Q, Feng S, Xiao Z, Wu W, Chen G, Deng L, Yu T, Wu J, Lin H, Ji B, Lin J, Zhang C, Li L, Liu T, Ouyang Y, Lei K, Chen J, Peng W, Qiu Z, Cai Q, Liang Q, Liu C, Li Y, Zhu L, Zhang Z, Liu X, Lin L, Zheng Z
Pharm Biol 2024 Dec;62(1):472-479. Epub 2024 May 20 doi: 10.1080/13880209.2024.2350233. PMID: 38769628Free PMC Article
Effect of auricular point pressing therapy on hyperplasia of mammary glands: A protocol for systematic review and meta-analysis.
Ma M, Zhang L, Wang X
Medicine (Baltimore) 2021 Apr 2;100(13):e24875. doi: 10.1097/MD.0000000000024875. PMID: 33787577Free PMC Article
Effect of Chinese herbal medicine compound on breast hyperplasia: A protocol of systematic review.
Guan HL, Wang Y, Gui YF, Zhang CL
Medicine (Baltimore) 2020 Dec 4;99(49):e23463. doi: 10.1097/MD.0000000000023463. PMID: 33285747Free PMC Article
Efficacy of Psychological Interventions for Patients with Breast Hyperplasia.
Chen CC, Jiang CG, Chen QQ, Gao D
Cell Biochem Biophys 2015 Apr;71(3):1663-9. doi: 10.1007/s12013-014-0388-4. PMID: 25634303Free PMC Article

Prognosis

Is Quality of Life After Breast Reduction Influenced by Different Surgery's Technique? A Prospective Study.
Molle M, Uderzo S, D'Addato C, Gesuete FP, Nicoletti GF, Ferraro GA
Aesthetic Plast Surg 2024 Dec;48(23):4973-4978. Epub 2024 May 20 doi: 10.1007/s00266-024-04050-w. PMID: 38769147
Expression and clinical prognostic value of CYB561 in breast cancer.
Zhou X, Shen G, Ren D, Guo X, Han J, Guo Q, Zhao F, Wang M, Dong Q, Li Z, Zhao J
J Cancer Res Clin Oncol 2022 Aug;148(8):1879-1892. Epub 2022 Apr 29 doi: 10.1007/s00432-022-03928-z. PMID: 35486183
The Clinical Application Value of RDW, CA153, and MPV in Breast Cancer.
Lu F, Pan S, Qi Y, Li X, Wang J
Clin Lab 2021 Feb 1;67(2) doi: 10.7754/Clin.Lab.2020.200507. PMID: 33616344
Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization.
Wang Y, Zeng J, Wu W, Xie S, Yu H, Li G, Zhu T, Li F, Lu J, Wang GY, Xie X, Zhang J
Breast Cancer Res 2019 May 17;21(1):64. doi: 10.1186/s13058-019-1150-z. PMID: 31101119Free PMC Article
The Clinical Value of Hepcidin in Breast Cancer and Its Bone Metastasis.
Shao X, Cao F, Tao M
Ann Clin Lab Sci 2017 Mar;47(2):120-128. PMID: 28442512

Clinical prediction guides

Clinical application and effect evaluation of acupoint thread embedding therapy and traditional Chinese medicine treatment based on menstrual cycle characteristics in the management of breast hyperplasia: An observational study.
Tao F, Hao Y, Wang D, Zhang W, Wang F
Medicine (Baltimore) 2024 Jun 28;103(26):e38502. doi: 10.1097/MD.0000000000038502. PMID: 38941407Free PMC Article
Guidelines for the clinical application of the Xihuang pill for the prevention and treatment of breast hyperplasia diseases.
Tang H, Lu Q, Feng S, Xiao Z, Wu W, Chen G, Deng L, Yu T, Wu J, Lin H, Ji B, Lin J, Zhang C, Li L, Liu T, Ouyang Y, Lei K, Chen J, Peng W, Qiu Z, Cai Q, Liang Q, Liu C, Li Y, Zhu L, Zhang Z, Liu X, Lin L, Zheng Z
Pharm Biol 2024 Dec;62(1):472-479. Epub 2024 May 20 doi: 10.1080/13880209.2024.2350233. PMID: 38769628Free PMC Article
Expression and clinical prognostic value of CYB561 in breast cancer.
Zhou X, Shen G, Ren D, Guo X, Han J, Guo Q, Zhao F, Wang M, Dong Q, Li Z, Zhao J
J Cancer Res Clin Oncol 2022 Aug;148(8):1879-1892. Epub 2022 Apr 29 doi: 10.1007/s00432-022-03928-z. PMID: 35486183
Gene expression signature of atypical breast hyperplasia and regulation by SFRP1.
Gregory KJ, Roberts AL, Conlon EM, Mayfield JA, Hagen MJ, Crisi GM, Bentley BA, Kane JJ, Makari-Judson G, Mason HS, Yu J, Zhu LJ, Simin K, Johnson JPS, Khan A, Schneider BR, Schneider SS, Jerry DJ
Breast Cancer Res 2019 Jun 27;21(1):76. doi: 10.1186/s13058-019-1157-5. PMID: 31248446Free PMC Article
Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization.
Wang Y, Zeng J, Wu W, Xie S, Yu H, Li G, Zhu T, Li F, Lu J, Wang GY, Xie X, Zhang J
Breast Cancer Res 2019 May 17;21(1):64. doi: 10.1186/s13058-019-1150-z. PMID: 31101119Free PMC Article

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