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PRY PTPN13 like Y-linked [ Homo sapiens (human) ]

Gene ID: 9081, updated on 4-Mar-2025

Summary

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Official Symbol
PRYprovided by HGNC
Official Full Name
PTPN13 like Y-linkedprovided by HGNC
Primary source
HGNC:HGNC:14024
See related
Ensembl:ENSG00000169789 MIM:400019; AllianceGenome:HGNC:14024
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRY1; PTPN13LY
Summary
This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more telomeric copy. [provided by RefSeq, Aug 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See PRY in Genome Data Viewer
Location:
Yq11.223
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (22490397..22514637)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (22907275..22931519, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (24636544..24660784)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein Y-linked family 1 member J Neighboring gene uncharacterized LOC101929148 Neighboring gene testis expressed transcript, Y-linked 6 Neighboring gene elongin C pseudogene 8 Neighboring gene chromodomain Y-linked 13 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Expression pattern of the Y-linked PRY gene suggests a function in apoptosis but not in spermatogenesis. Stouffs K, et al. Mol Hum Reprod, 2004 Jan. PMID 14665702
  2. Characterization of the genomic organization, localization and expression of four PRY genes (PRY1, PRY2, PRY3 and PRY4). Stouffs K, et al. Mol Hum Reprod, 2001 Jul. PMID 11420382
  3. A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. Repping S, et al. Genomics, 2004 Jun. PMID 15177557
  4. Y Chromosome Infertility. Adam MP, et al. , 1993. PMID 20301513
  5. Functional coherence of the human Y chromosome. Lahn BT, et al. Science, 1997 Oct 24. PMID 9381176

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Spermatogenic failure, Y-linked, 2
MedGen: C1839071 OMIM: 415000 GeneReviews: Y Chromosome Infertility
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • testis-specific PTP-BL-related protein on Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_197358.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008175
    Related
    ENST00000303728.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    22490397..22514637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    22907275..22931519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_032916.1: Suppressed sequence

    Description
    NG_032916.1: This RefSeq was removed by NCBI staff.

  2. NM_004676.2: Suppressed sequence

    Description
    NM_004676.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14603.2 GenPept UniProtKB/Swiss-Prot:O14603

Gene LinkOut

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