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UGT74F1 UDP-glycosyltransferase 74 F1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818988, updated on 19-Feb-2025

Summary

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Official Symbol
UGT74F1
Official Full Name
UDP-glycosyltransferase 74 F1
Primary source
TAIR:AT2G43840
Locus tag
AT2G43840
See related
Araport:AT2G43840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F18O19.5; UDP-glycosyltransferase 74 F1
Summary
UGT74F1 transfers UDP:glucose to salicylic acid (forming a glucoside), benzoic acid, quercetin, and athranilate in vitro. UGT74F1 shows a weak ability to catalyze the formation of the p-aminobenzoate-glucose ester in vitro. But, UGT75B1 appears to be the dominant pABA acylglucosyltransferase in vivo based on assays in leaves, flowers, and siliques. The true biological substrate(s) of UGT74F1 are not known, but mutant plants lacking UGT74F1 have a decreased level of salicylate glucoside.
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Genomic context

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See UGT74F1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
2
Sequence:
Chromosome: 2; NC_003071.7 (18157529..18159231)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Small nuclear ribonucleoprotein family protein Neighboring gene UDP-glucosyltransferase 74F2 Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene Integrin-linked protein kinase family Neighboring gene Pectin lyase-like superfamily protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana. George Thompson AM, et al. Sci Rep, 2017 Apr 20. PMID 28425481, Free PMC Article
  2. Metabolism of salicylic acid in wild-type, ugt74f1 and ugt74f2 glucosyltransferase mutants of Arabidopsis thaliana. Dean JV, et al. Physiol Plant, 2008 Apr. PMID 18248508
  3. Metabolism of the folate precursor p-aminobenzoate in plants: glucose ester formation and vacuolar storage. Eudes A, et al. J Biol Chem, 2008 May 30. PMID 18385129, Free PMC Article
  4. The activity of Arabidopsis glycosyltransferases toward salicylic acid, 4-hydroxybenzoic acid, and other benzoates. Lim EK, et al. J Biol Chem, 2002 Jan 4. PMID 11641410
  5. Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides. Lim EK, et al. Biotechnol Bioeng, 2004 Sep 5. PMID 15352060

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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NM_129946.3
NM_201953.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables UDP-glucose:4-aminobenzoate acylglucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables benzoic acid glucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables quercetin 4'-O-glucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables quercetin 7-O-glucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables salicylic acid glucosyltransferase (glucoside-forming) activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within benzoate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within para-aminobenzoic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within salicylic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
UDP-glycosyltransferase 74 F1
NP_181912.1
  • UDP-glycosyltransferase 74 F1 (UGT74F1); CONTAINS InterPro DOMAIN/s: UDP-glucuronosyl/UDP-glucosyltransferase (InterPro:IPR002213); BEST Arabidopsis thaliana protein match is: UDP-glucosyltransferase 74F2 (TAIR:AT2G43820.1); Has 8300 Blast hits to 8222 proteins in 540 species: Archae - 0; Bacteria - 767; Metazoa - 2272; Fungi - 26; Plants - 5053; Viruses - 115; Other Eukaryotes - 67 (source: NCBI BLink).
NP_973682.1
  • UDP-glycosyltransferase 74 F1 (UGT74F1); CONTAINS InterPro DOMAIN/s: UDP-glucuronosyl/UDP-glucosyltransferase (InterPro:IPR002213); BEST Arabidopsis thaliana protein match is: UDP-glucosyltransferase 74F2 (TAIR:AT2G43820.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    18157529..18159231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_201953.2 → NP_973682.1  UDP-glycosyltransferase 74 F1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973682.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654F6V9, F4IS54
    Conserved Domains (1) summary
    PLN02173
    Location:1 → 449
    PLN02173; UDP-glucosyl transferase family protein

  2. NM_129946.3 → NP_181912.1  UDP-glycosyltransferase 74 F1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181912.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22820, Q56XT4
    UniProtKB/TrEMBL
    A0A178VQD2, A0A384LDG7, A0A654F6V9, W8Q6W5
    Conserved Domains (1) summary
    PLN02173
    Location:1 → 449
    PLN02173; UDP-glucosyl transferase family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22820.1

Gene LinkOut

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