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TRU-TCA1-1 tRNA-SeC (anticodon TCA) 1-1 [ Homo sapiens (human) ]

Gene ID: 7234, updated on 8-Mar-2025

Summary

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Official Symbol
TRU-TCA1-1provided by HGNC
Official Full Name
tRNA-SeC (anticodon TCA) 1-1provided by HGNC
Primary source
HGNC:HGNC:12348
See related
MIM:165060; AllianceGenome:HGNC:12348
Gene type
tRNA
RefSeq status
MODEL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRSP; THMA3; TRNAU1; tRNA(Sec)
Summary
Opal suppressor phosphoserine tRNAs are the only authentic, naturally occurring suppressor tRNAs in higher eukaryotes. The human genome contains a single opal suppressor phosphoserine tRNA gene, TRNAU1 (O'Neill et al., 1985 [PubMed 3156131]).[supplied by OMIM, Nov 2010]
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Genomic context

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See TRU-TCA1-1 in Genome Data Viewer
Location:
19q13.32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45478601..45478687, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48305850..48305936, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45981860..45981945, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ERCC excision repair 1, endonuclease non-catalytic subunit Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45943151-45943650 Neighboring gene microRNA 6088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10768 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14797 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45958106-45959072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45959073-45960039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45967946-45968446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45968447-45968947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45971355-45972256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14799 Neighboring gene FosB proto-oncogene, AP-1 transcription factor subunit Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10772 Neighboring gene reticulon 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10774 Neighboring gene uncharacterized LOC107985314 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regional localization of the selenocysteine tRNA gene (TRSP) on human chromosome 19. Mitchell A, et al. Cytogenet Cell Genet, 1992. PMID 1395717
  2. A human opal suppressor tRNA gene and pseudogene. O'Neill VA, et al. J Biol Chem, 1985 Feb 25. PMID 3156131
  3. Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency. Schoenmakers E, et al. Int J Mol Sci, 2021 Nov 29. PMID 34884733, Free PMC Article
  4. GtRNAdb: a database of transfer RNA genes detected in genomic sequence. Chan PP, et al. Nucleic Acids Res, 2009 Jan. PMID 18984615, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency.
    Title: Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Thyroid hormone metabolism, abnormal, 3
MedGen: C5774292 OMIM: 620198 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Other Names

  • tRNA phosphoserine (opal suppressor)
  • tRNA selenocysteine/phosphoserine (opal suppressor)
  • tRNA-SeC-TCA-1-1
  • transfer RNA selenocysteine 1 (anticodon UCA)
  • transfer RNA selenocysteine/phosphoserine (opal suppressor)
  • transfer RNA-SeC (TCA) 1-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    45478601..45478687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48305850..48305936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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