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MID1 midline 1 [ Gallus gallus (chicken) ]

Gene ID: 373920, updated on 3-Dec-2024

Summary

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Symbol
MID1provided by CGNC
Full Name
midline 1provided by CGNC
Primary source
CGNC:48957
See related
Ensembl:ENSGALG00010002012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See MID1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
16
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (124646339..124888022)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (124601466..124843246)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat-containing protein family member 2B Neighboring gene uncharacterized LOC124417631 Neighboring gene chloride voltage-gated channel 4 Neighboring gene WWC family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterisation of the chick orthologue of the Opitz syndrome gene, Mid1, supports a conserved role in vertebrate development. Richman JM, et al. Int J Dev Biol, 2002. PMID 12141430
  2. Regulation of PP2A activity by Mid1 controls cranial neural crest speed and gangliogenesis. Latta EJ, et al. Mech Dev, 2012 Jan-Feb. PMID 22285438
  3. Evidence of functional redundancy between MID proteins: implications for the presentation of Opitz syndrome. Granata A, et al. Dev Biol, 2005 Jan 15. PMID 15617684
  4. The Opitz syndrome gene MID1 is essential for establishing asymmetric gene expression in Hensen's node. Granata A, et al. Dev Biol, 2003 Jun 15. PMID 12798296
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suppression of Mid1 function in r2 elevates PP2Ac protein, whilst ectopic expression of Mid1 depletes PP2Ac protein.
    Title: Regulation of PP2A activity by Mid1 controls cranial neural crest speed and gangliogenesis.
  2. A mutually repressive relationship between Mid1 and Shh in Hensen's node plays a key role in establishing the avian left-right axis.
    Title: Evidence of functional redundancy between MID proteins: implications for the presentation of Opitz syndrome.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Midline-1
Names
midline 1 (Opitz/BBB syndrome)
NP_001384590.1
NP_001384591.1
NP_001384592.1
NP_001384593.1
NP_001384594.1
NP_989460.2
XP_025004304.2
XP_025004317.2
XP_025004353.2
XP_040552626.1
XP_046762229.1
XP_046762230.1
XP_046762231.1
XP_046762233.1
XP_046762234.1
XP_046794869.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397661.1 → NP_001384590.1  E3 ubiquitin-protein ligase Midline-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000024
    UniProtKB/TrEMBL
    A0A8V0XB44, Q90WD1
    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:381 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12892
    Location:485 → 661
    SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain

  2. NM_001397662.1 → NP_001384591.1  E3 ubiquitin-protein ligase Midline-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000024
    UniProtKB/TrEMBL
    A0A8V0XB44, Q90WD1
    Related
    ENSGALP00010002778.1, ENSGALT00010004571.1
    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:381 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12892
    Location:485 → 661
    SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain

  3. NM_001397663.1 → NP_001384592.1  E3 ubiquitin-protein ligase Midline-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000024
    UniProtKB/TrEMBL
    A0A8V0XB44, Q90WD1
    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:381 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12892
    Location:485 → 661
    SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain

  4. NM_001397664.1 → NP_001384593.1  E3 ubiquitin-protein ligase Midline-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000024
    UniProtKB/TrEMBL
    A0A8V0X812, A0A8V0XB44
    Conserved Domains (6) summary
    smart00502
    Location:251 → 372
    BBC; B-Box C-terminal domain
    cd00063
    Location:409 → 509
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12892
    Location:513 → 689
    SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

  5. NM_001397665.1 → NP_001384594.1  E3 ubiquitin-protein ligase Midline-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000024
    UniProtKB/TrEMBL
    A0A8V0X812, A0A8V0XB44
    Related
    ENSGALP00010002773.1, ENSGALT00010004561.1
    Conserved Domains (6) summary
    smart00502
    Location:251 → 372
    BBC; B-Box C-terminal domain
    cd00063
    Location:409 → 509
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12892
    Location:513 → 689
    SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

  6. NM_204129.2 → NP_989460.2  E3 ubiquitin-protein ligase Midline-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000024
    UniProtKB/TrEMBL
    A0A8V0XB44, Q90WD1
    Related
    ENSGALP00010002776.1, ENSGALT00010004567.1
    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:381 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12892
    Location:485 → 661
    SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    124646339..124888022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025148536.3 → XP_025004304.2  E3 ubiquitin-protein ligase Midline-1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X812, A0A8V0XB44
    Conserved Domains (6) summary
    smart00502
    Location:251 → 372
    BBC; B-Box C-terminal domain
    cd00063
    Location:409 → 509
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12892
    Location:513 → 689
    SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

  2. XM_025148585.3 → XP_025004353.2  E3 ubiquitin-protein ligase Midline-1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X812, A0A8V0XB44
    Conserved Domains (6) summary
    smart00502
    Location:251 → 372
    BBC; B-Box C-terminal domain
    cd00063
    Location:409 → 509
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12892
    Location:513 → 689
    SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

  3. XM_040696692.2 → XP_040552626.1  E3 ubiquitin-protein ligase Midline-1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XB44, Q90WD1
    Conserved Domains (7) summary
    smart00502
    Location:219 → 344
    BBC; B-Box C-terminal domain
    cd00063
    Location:381 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12892
    Location:485 → 661
    SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain

  4. XM_025148549.3 → XP_025004317.2  E3 ubiquitin-protein ligase Midline-1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X812, A0A8V0XB44
    Conserved Domains (6) summary
    smart00502
    Location:251 → 372
    BBC; B-Box C-terminal domain
    cd00063
    Location:409 → 509
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12892
    Location:513 → 689
    SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
    cd16753
    Location:8 → 61
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168 → 214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115 → 164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

  5. XM_046938913.1 → XP_046794869.1  E3 ubiquitin-protein ligase Midline-1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X812, A0A8V0XB44

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    124601466..124843246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906274.1 → XP_046762230.1  E3 ubiquitin-protein ligase Midline-1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XB44

  2. XM_046906275.1 → XP_046762231.1  E3 ubiquitin-protein ligase Midline-1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XB44

  3. XM_046906278.1 → XP_046762234.1  E3 ubiquitin-protein ligase Midline-1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PG57, A0A8V0XB44, Q71R46

  4. XM_046906273.1 → XP_046762229.1  E3 ubiquitin-protein ligase Midline-1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XB44

  5. XM_046906277.1 → XP_046762233.1  E3 ubiquitin-protein ligase Midline-1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XB44
Nucleotide Protein Strain
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