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ZNF836 zinc finger protein 836 [ Homo sapiens (human) ]

Gene ID: 162962, updated on 8-Mar-2025

Summary

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Official Symbol
ZNF836provided by HGNC
Official Full Name
zinc finger protein 836provided by HGNC
Primary source
HGNC:HGNC:34333
See related
Ensembl:ENSG00000196267 AllianceGenome:HGNC:34333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Expression
Ubiquitous expression in adrenal (RPKM 5.5), ovary (RPKM 1.8) and 24 other tissues See more
Orthologs
all
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Genomic context

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See ZNF836 in Genome Data Viewer
Location:
19q13.41
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52154107..52171621, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55241321..55258831, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52657360..52674874, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 616 Neighboring gene uncharacterized LOC124904799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10992 Neighboring gene ribosomal protein L37 pseudogene 23 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15037 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52691895-52692862 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52692863-52693830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:52695753-52696253 Neighboring gene protein phosphatase 2 scaffold subunit Aalpha Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:52724813-52726012 Neighboring gene uncharacterized LOC105372449 Neighboring gene microRNA 6801 Neighboring gene vomeronasal 1 receptor 99 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  2. Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease. Viard J, et al. Life Sci Alliance, 2022 Aug 1. PMID 35914814, Free PMC Article
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16287

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 836

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102657.3 → NP_001096127.1  zinc finger protein 836

    See identical proteins and their annotated locations for NP_001096127.1

    Status: VALIDATED

    Source sequence(s)
    AC010320, AC011468
    Consensus CDS
    CCDS46162.1
    UniProtKB/Swiss-Prot
    Q6ZNA1
    Related
    ENSP00000507838.1, ENST00000682614.1
    Conserved Domains (6) summary
    smart00349
    Location:8 → 48
    KRAB; krueppel associated box
    COG5048
    Location:272 → 648
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:304 → 324
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:696 → 714
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:372 → 397
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52154107..52171621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526559.4 → XP_011524861.1  zinc finger protein 836 isoform X1

    See identical proteins and their annotated locations for XP_011524861.1

    UniProtKB/Swiss-Prot
    Q6ZNA1
    Conserved Domains (6) summary
    smart00349
    Location:8 → 48
    KRAB; krueppel associated box
    COG5048
    Location:272 → 648
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:304 → 324
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:696 → 714
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:372 → 397
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011526558.4 → XP_011524860.1  zinc finger protein 836 isoform X1

    See identical proteins and their annotated locations for XP_011524860.1

    UniProtKB/Swiss-Prot
    Q6ZNA1
    Conserved Domains (6) summary
    smart00349
    Location:8 → 48
    KRAB; krueppel associated box
    COG5048
    Location:272 → 648
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:304 → 324
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:696 → 714
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:372 → 397
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55241321..55258831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320022.1 → XP_054175997.1  zinc finger protein 836 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZNA1

  2. XM_054320021.1 → XP_054175996.1  zinc finger protein 836 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZNA1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZNA1.2 GenPept UniProtKB/Swiss-Prot:Q6ZNA1

Gene LinkOut

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