Gnrh1 gonadotropin releasing hormone 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gnrh1provided by MGI
Official Full Name: gonadotropin releasing hormone 1provided by MGI
Primary source: MGI:MGI:95789
See related: Ensembl:ENSMUSG00000015812 AllianceGenome:MGI:95789
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: hpg; Gnrh; LHRH; Lnrh; Gnrh2; Lhrh1
Summary: This gene encodes hypophysiotropic peptides belonging to the family of gonadotropin-releasing hormones that stimulate the release of gonadotropins and suppress secretion of prolactin from the pituitary gland. The encoded protein is proteolytically processed to generate two biologically active mature peptides. A deletional mutation encompassing the distal half of this gene in mice resulting in the loss of the encoded protein leads to hypogonadism and infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Expression: Ubiquitous expression in bladder adult (RPKM 1.8), liver E14 (RPKM 1.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 34.66 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (67982717..67986889)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (67745181..67749440)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Development and prenatal exposure to androgens alter potassium currents in gonadotropin-releasing hormone neurons from female mice.
Title: Development and prenatal exposure to androgens alter potassium currents in gonadotropin-releasing hormone neurons from female mice.
Disruption of Intranasal GnRH Neuronal Migration Route into the Brain Induced by Proinflammatory Cytokine IL-6: Ex Vivo and In Vivo Rodent Models.
Title: Disruption of Intranasal GnRH Neuronal Migration Route into the Brain Induced by Proinflammatory Cytokine IL-6: Ex Vivo and In Vivo Rodent Models.
Hypothalamic PVN CRH Neurons Signal Through PVN GABA Neurons to Suppress GnRH Pulse Generator Frequency in Female Mice.
Title: Hypothalamic PVN CRH Neurons Signal Through PVN GABA Neurons to Suppress GnRH Pulse Generator Frequency in Female Mice.
Kisspeptin induces Kiss-1 and GnRH gene expression in mHypoA-55 hypothalamic cell models: Involvement of the ERK and PKA signaling pathways.
Title: Kisspeptin induces Kiss-1 and GnRH gene expression in mHypoA-55 hypothalamic cell models: Involvement of the ERK and PKA signaling pathways.
Age-related changes in gonadotropin-releasing hormone (GnRH) splice variants in mouse brain.
Title: Age-related changes in gonadotropin-releasing hormone (GnRH) splice variants in mouse brain.
Ovariectomy induces abdominal fat accumulation by improving gonadotropin-releasing hormone secretion in mouse.
Title: Ovariectomy induces abdominal fat accumulation by improving gonadotropin-releasing hormone secretion in mouse.
MiR-375 potentially enhances GnRH expression by targeting Sp1 in GT1-7 cells.
Title: MiR-375 potentially enhances GnRH expression by targeting Sp1 in GT1-7 cells.
Roles of Pyk2 in signal transduction after gonadotropin-releasing hormone receptor stimulation.
Title: Roles of Pyk2 in signal transduction after gonadotropin-releasing hormone receptor stimulation.
Mitochondrial dysfunction in GnRH neurons impaired GnRH production.
Title: Mitochondrial dysfunction in GnRH neurons impaired GnRH production.
Results indicate that miR-29-3p and its target T-box 21 protein (Tbx21) play a role in regulating the mammalian puberty onset and reproduction by modulating the gonadotropin releasing hormone 1 (Gnrh1) expression.
Title: miR-29 family regulates the puberty onset mediated by a novel Gnrh1 transcription factor TBX21.

Submit: New GeneRIF Correction See all GeneRIFs (147)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)
Spontaneous (1) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492567

Gnrh (e-PCR), detects polymorphism
- UniSTS:143231

Gnrh (e-PCR), detects polymorphism
- UniSTS:143232

D14Mit28 (e-PCR), detects polymorphism
- UniSTS:127385

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables gonadotropin hormone-releasing hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables gonadotropin hormone-releasing hormone activity	IEA Inferred from Electronic Annotation more info
enables gonadotropin hormone-releasing hormone activity	ISO Inferred from Sequence Orthology more info
enables gonadotropin-releasing hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in male sex determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immature T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to ethanol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to steroid hormone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi-associated vesicle	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of rough endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neurosecretory vesicle	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: progonadoliberin-1

Names: gonadotropin releasing hormone 2; luteinizing hormone-releasing hormone I; progonadoliberin I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.