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LOC129663689 ReSE screen-validated silencer GRCh37_chr15:91189835-91190018 [ Homo sapiens (human) ]

Gene ID: 129663689, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129663689
Gene description
ReSE screen-validated silencer GRCh37_chr15:91189835-91190018
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129663689 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90646604..90646787)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (88402619..88402802)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91189835..91190018)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CREB regulated transcription coactivator 3 Neighboring gene uncharacterized LOC124903554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10081 Neighboring gene CRTC3 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:91183956-91185155 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91203621-91204149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6826 Neighboring gene long intergenic non-protein coding RNA 1585 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10089 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91226288-91226788 Neighboring gene BLM RecQ like helicase Neighboring gene small nucleolar RNA SNORD18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_160695.1 

    Range
    101..284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    90646604..90646787
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    88402619..88402802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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