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LOC129663460 ReSE screen-validated silencer GRCh37_chr14:75049938-75050130 [ Homo sapiens (human) ]

Gene ID: 129663460, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129663460
Gene description
ReSE screen-validated silencer GRCh37_chr14:75049938-75050130
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in HepG2 liver carcinoma cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129663460 in Genome Data Viewer
Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74583235..74583427)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68792315..68792507)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75049938..75050130)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene latent transforming growth factor beta binding protein 2 Neighboring gene uncharacterized LOC124903347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:74989151-74990029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:74990491-74991430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:74993815-74994316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:74994959-74995460 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75018058-75018721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75018722-75019386 Neighboring gene uncharacterized LOC124903346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75021824-75022324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75022325-75022825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75078996-75079623 Neighboring gene uncharacterized LOC101928352 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:75084232-75085431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75088895-75089761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75097447-75098096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75098097-75098745 Neighboring gene Sharpr-MPRA regulatory region 14689 Neighboring gene uncharacterized LOC105370567

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_160466.1 

    Range
    101..293
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    74583235..74583427
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    68792315..68792507
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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