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LOC127896370 H3K4me1 hESC enhancer GRCh37_chr22:41593165-41593664 [ Homo sapiens (human) ]

Gene ID: 127896370, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127896370
Gene description
H3K4me1 hESC enhancer GRCh37_chr22:41593165-41593664
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K4me1 histone modification. This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127896370 in Genome Data Viewer
Location:
chromosome: 22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (41197161..41197660)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (41672097..41672596)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41593165..41593664)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene E1A binding protein p300 Neighboring gene RNA, U6 small nuclear 375, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41580503-41581302 Neighboring gene EP300 antisense RNA 1 Neighboring gene leucine rich repeat containing 37 member A14, pseudogene Neighboring gene uncharacterized LOC646927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41602160-41602660 Neighboring gene L3MBTL2 antisense RNA 1 Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41613805-41614502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:41614503-41615199 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41632734-41633322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41633323-41633911 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41633912-41634500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41634501-41635088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41636538-41637038 Neighboring gene chondroadherin like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 13780

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_145901.1 

    Range
    101..600
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    41197161..41197660
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    41672097..41672596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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