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LOC127828080 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77499197-77499746 [ Homo sapiens (human) ]

Gene ID: 127828080, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127828080
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77499197-77499746
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127828080 in Genome Data Viewer
Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (77032854..77033403)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (71242586..71243136)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77499197..77499746)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:77435045-77435585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77437073-77437574 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77444395-77444896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77446989-77447488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77459676-77460176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77460177-77460677 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77461395-77461903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8785 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77467477-77468181 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77473739-77474268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77479792-77480588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77480589-77481385 Neighboring gene Sharpr-MPRA regulatory region 8154 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:77490390-77490615 Neighboring gene uncharacterized LOC107984638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77496104-77496624 Neighboring gene uncharacterized LOC105370579 Neighboring gene interferon regulatory factor 2 binding protein like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5964 Neighboring gene VISTA enhancer hs1903 Neighboring gene long intergenic non-protein coding RNA 2288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77519369-77519932 Neighboring gene Sharpr-MPRA regulatory region 7445 Neighboring gene long intergenic non-protein coding RNA 2289 Neighboring gene Sharpr-MPRA regulatory region 8378 Neighboring gene uncharacterized LOC124903350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77564243-77565072

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 8786

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_129579.1 

    Range
    101..650
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    77032854..77033403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    71242586..71243136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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