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LOC127407747 H3K27ac hESC enhancer GRCh37_chr6:162760145-162760692 [ Homo sapiens (human) ]

Gene ID: 127407747, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127407747
Gene description
H3K27ac hESC enhancer GRCh37_chr6:162760145-162760692
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127407747 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (162339113..162339660)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (163702299..163702846)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (162760145..162760692)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378098 Neighboring gene NANOG hESC enhancer GRCh37_chr6:161919346-161919847 Neighboring gene parkin RBR E3 ubiquitin protein ligase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:161939551-161940051 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:161954848-161955039 Neighboring gene Sharpr-MPRA regulatory region 5576 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:162074308-162074601 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:162074817-162076016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:162102647-162103226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:162103227-162103804 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:162148005-162148758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25415 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:162399319-162399820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:162399821-162400320 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:162484237-162485436 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:162520224-162521423 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:162621359-162622558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:162639333-162639833 Neighboring gene lncRNA senescence and mitophagy associated regulator of PRKN Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:162759597-162760144 Neighboring gene uncharacterized LOC105369171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:162888287-162888788 Neighboring gene NANOG hESC enhancer GRCh37_chr6:162909371-162909872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:162952273-162953090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:162963903-162964402 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:162967043-162967544 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:162967545-162968044 Neighboring gene keratin 8 pseudogene 44

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_109717.1 

    Range
    101..648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    162339113..162339660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    163702299..163702846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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