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LOC127405437 OCT4-NANOG hESC enhancer GRCh37_chr6:15745025-15745698 [ Homo sapiens (human) ]

Gene ID: 127405437, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127405437
Gene description
OCT4-NANOG hESC enhancer GRCh37_chr6:15745025-15745698
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127405437 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (15744794..15745467)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (15617057..15617730)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (15745025..15745698)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374947 Neighboring gene MPRA-validated peak5680 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:15551965-15552513 Neighboring gene Sharpr-MPRA regulatory region 14615 Neighboring gene dystrobrevin binding protein 1 Neighboring gene DTNBP1 antisense RNA 1 Neighboring gene MPRA-validated peak5681 silencer Neighboring gene MPRA-validated peak5682 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24086 Neighboring gene MPRA-validated peak5684 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr6:15641694-15641884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16953 Neighboring gene MPRA-validated peak5686 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:15725723-15726536 Neighboring gene uncharacterized LOC102724520 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:15745699-15746372 Neighboring gene MPRA-validated peak5688 silencer Neighboring gene MPRA-validated peak5689 silencer Neighboring gene uncharacterized LOC105374948 Neighboring gene MPRA-validated peak5691 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:15855489-15856036 Neighboring gene MPRA-validated peak5692 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24088 Neighboring gene Sharpr-MPRA regulatory region 4250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24094 Neighboring gene Sharpr-MPRA regulatory region 12068 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:15912456-15913115 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_107408.1 

    Range
    101..774
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    15744794..15745467
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    15617057..15617730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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