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LOC127402268 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1502148-1503038 [ Homo sapiens (human) ]

Gene ID: 127402268, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127402268
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1502148-1503038
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127402268 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (1502033..1502923)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (1413730..1414620)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (1502148..1503038)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:1404958-1406157 Neighboring gene solute carrier family 6 member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1412675-1413175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1414882-1415854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1415855-1416827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1422785-1423310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1438947-1439628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1446193-1446692 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:1455983-1457182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1464924-1465753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1467037-1467537 Neighboring gene lysophosphatidylcholine acyltransferase 1 Neighboring gene uncharacterized LOC124901162 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:1494052-1495251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1500365-1501256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1501257-1502147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1508748-1509266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1509267-1509784 Neighboring gene Sharpr-MPRA regulatory region 9592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1513221-1513780 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1514341-1514899 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1514900-1515460 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1515461-1516020 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1516021-1516580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1517140-1517700 Neighboring gene microRNA 6075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1521598-1522102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15882 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15884 Neighboring gene CRISPRi-validated cis-regulatory element chr5.422 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:1536432-1536569 Neighboring gene uncharacterized LOC124901161

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_104227.1 

    Range
    101..991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    1502033..1502923
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187547.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    6850..7740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    1413730..1414620
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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