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LOC127274738 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129120088-129120626 [ Homo sapiens (human) ]

Gene ID: 127274738, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127274738
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129120088-129120626
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127274738 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (128362514..128363052)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (128798318..128798856)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (129120088..129120626)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907886 Neighboring gene Sharpr-MPRA regulatory region 14953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129019563-129020132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129020147-129020648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129028169-129028830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129028831-129029492 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129042083-129042912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129045407-129046236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129052695-129053244 Neighboring gene heparan sulfate 6-O-sulfotransferase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129057516-129058114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129058115-129058712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129058713-129059311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16511 Neighboring gene Sharpr-MPRA regulatory region 5144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129067670-129068650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129068651-129069632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129080477-129081409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129102864-129103364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129119009-129119548 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129119549-129120087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129124244-129124934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129125695-129126536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129132078-129132952 Neighboring gene uncharacterized LOC105373610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129142763-129143262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129146579-129147236 Neighboring gene uncharacterized LOC105373611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129165673-129166670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129166671-129167666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129195850-129196350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129196351-129196851 Neighboring gene RNA, 5S ribosomal pseudogene 103

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_096588.1 

    Range
    101..639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    128362514..128363052
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    128798318..128798856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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