U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126862337 BRD4-independent group 4 enhancer GRCh37_chr16:47920785-47921984 [ Homo sapiens (human) ]

Gene ID: 126862337, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
LOC126862337
Gene description
BRD4-independent group 4 enhancer GRCh37_chr16:47920785-47921984
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. Another subregion was also validated as an enhancer by ChIP-STARR-seq in naive human embryonic stem cells, where it associates with the NANOG transcription factor and is marked by the H3K27ac histone modification. [provided by RefSeq, Jan 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC126862337 in Genome Data Viewer
Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (47886874..47888428)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (53683682..53685236)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (47920785..47922339)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene phosphorylase kinase regulatory subunit beta Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 11 Neighboring gene NANOG hESC enhancer GRCh37_chr16:47660051-47660552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:47752345-47752845 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:47767625-47768824 Neighboring gene uncharacterized LOC105371236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10788 Neighboring gene NANOG hESC enhancer GRCh37_chr16:47882414-47883106 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:47898419-47899379 Neighboring gene long intergenic non-protein coding RNA 2192 Neighboring gene long intergenic non-protein coding RNA 2133 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:47922340-47923153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:47937837-47938338 Neighboring gene uncharacterized LOC124903685 Neighboring gene uncharacterized LOC105371237

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Other Names

  • NANOG-H3K27ac hESC enhancer GRCh37_chr16:47921525-47922339

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086835.2 

    Range
    101..1655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    47886874..47888428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    53683682..53685236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases