NLM DIR Seminar Schedule
UPCOMING SEMINARS
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March 11, 2025 Sofya Garushyants
Tmn – bacterial anti-phage defense system -
March 18, 2025 MG Hirsch
TBD -
March 25, 2025 Yifan Yang
TBD -
April 1, 2025 Roman Kogay
TBD -
April 8, 2025 Jaya Srivastava
TBD
RECENT SEMINARS
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March 4, 2025 Sanasar Babajanyan
Evolution of antivirus defense in prokaryotes depending on the environmental virus load -
Feb. 25, 2025 Zhizheng Wang
GeneAgent: Self-verification Language Agent for Gene Set Analysis using Domain Databases -
Feb. 18, 2025 Samuel Lee
Efficient predictions of alternative protein conformations by AlphaFold2-based sequence association -
Feb. 11, 2025 Po-Ting Lai
Enhancing Biomedical Relation Extraction with Directionality -
Feb. 4, 2025 Victor Tobiasson
On the dominance of Asgard contributions to Eukaryogenesis
The NLM DIR holds a public weekly seminar series for NLM trainees, staff scientists, and investigators to share details on current and exciting research projects at NLM. Seminars take place on Tuesdays at 11:00 AM, EST and some Thursdays at 3:00 PM, EST. Seminars are held in the B2 Library of Building 38A on the main NIH campus in Bethesda, MD. Due to the Covid-19 pandemic, all seminars are currently held virtually.
To schedule a seminar, click the “Schedule Seminar” button to the right, select an appropriate date on the calendar to sign up, and then complete the form. You will need an NIH PIV card to access the “Schedule Seminar” page.
Please include seminars by invited visiting scientists in the NLM DIR seminar series. These need not be on a Tuesday or Thursday.
If you would like to schedule a seminar by a visiting scientist, click the “Schedule Seminar” and complete the form. Contact NLMDIRSeminarScheduling@mail.nih.gov with questions. Please follow this link to subscribe/unsubscribe to/from the NLM DIR seminar mailing list.
Titles and Abstracts for Upcoming Seminars
(based on the current date)
Tmn – bacterial anti-phage defense system
Bacterial defense systems against phages are diverse, yet mechanisms involving membrane-associated components remain largely unexplored. Here, I will characterize Tmn, a member of the KAP NTPase family, as a membrane-associated defense system that targets phage infection through reversible plasmolysis. Tmn activation requires direct interactions with phage proteins expressed during infection. Upon activation, Tmn manipulates potassium export to induce plasmolysis, disrupting phage maturation at a stage where host chromosome degradation is avoided. These findings reveal that Tmn provides an elegant strategy to disrupt phage replication while enabling host cell recovery, underscoring the diverse adaptations of membrane-targeting bacterial defense systems.
TBD
TBD