Hyperlipidemic response to endotoxin--a part of the host-defence mechanism
- PMID: 8052806
- DOI: 10.3109/00365549309008562
Hyperlipidemic response to endotoxin--a part of the host-defence mechanism
Abstract
Endotoxin administration into experimental animals leads to an acute hyperlipidemic response. In addition, lipoproteins can inhibit various biological activities of endotoxin both in vitro and in vivo. The endotoxin-binding and endotoxin-inactivating abilities of lipoproteins, as well as the plasma levels of lipoproteins, are thus increased following endotoxin administration. The endotoxin-induced hyperlipoproteinemia may not only represent the consequence of endotoxemia, but may also be a physiological defence mechanism whereby the body attempts to combat the toxic effects of circulating endotoxin. This minireview discusses the interaction between lipoproteins and endotoxin, and the role of this acute hyperlipidemic response to endotoxin in the context of the host-defence mechanism.
Similar articles
-
Chylomicrons can inhibit endotoxin activity in vitro.J Surg Res. 1991 Nov;51(5):413-6. doi: 10.1016/0022-4804(91)90143-a. J Surg Res. 1991. PMID: 1758174
-
Effects of endotoxin on lipid metabolism.Biochem Soc Trans. 1995 Nov;23(4):1013-8. doi: 10.1042/bst0231013. Biochem Soc Trans. 1995. PMID: 8654672 Review.
-
Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice.J Clin Invest. 1990 Sep;86(3):696-702. doi: 10.1172/JCI114765. J Clin Invest. 1990. PMID: 2394827 Free PMC article.
-
Endogenous lipoproteins impact the response to endotoxin in humans.Crit Care Med. 2002 Jan;30(1):23-31. doi: 10.1097/00003246-200201000-00004. Crit Care Med. 2002. PMID: 11902267 Clinical Trial.
-
The protective effect of serum lipoproteins against bacterial lipopolysaccharide.Eur Heart J. 1993 Dec;14 Suppl K:125-9. Eur Heart J. 1993. PMID: 8131781 Review.
Cited by
-
The impact of antihypertensive drug therapy on endotoxemia in elderly patients with chronic kidney disease.Clin J Am Soc Nephrol. 2011 Oct;6(10):2389-94. doi: 10.2215/CJN.11211210. Epub 2011 Aug 18. Clin J Am Soc Nephrol. 2011. PMID: 21852662 Free PMC article.
-
Effect of hypertriglyceridemia on endotoxin responsiveness in humans.Infect Immun. 1995 Sep;63(9):3396-400. doi: 10.1128/iai.63.9.3396-3400.1995. Infect Immun. 1995. PMID: 7642268 Free PMC article.
-
Concordance of endotoxemia with gram-negative bacteremia in patients with gram-negative sepsis: a meta-analysis.J Clin Microbiol. 1994 Sep;32(9):2120-7. doi: 10.1128/jcm.32.9.2120-2127.1994. J Clin Microbiol. 1994. PMID: 7814535 Free PMC article.
-
D-dimer improves the prognostic value of combined clinical and laboratory data in equine gastrointestinal colic.Acta Vet Scand. 1995;36(2):255-72. doi: 10.1186/BF03547694. Acta Vet Scand. 1995. PMID: 7484552 Free PMC article.
-
Endotoxin suppresses rat hepatic low-density lipoprotein receptor expression.Biochem J. 1996 Feb 1;313 ( Pt 3)(Pt 3):873-8. doi: 10.1042/bj3130873. Biochem J. 1996. PMID: 8611169 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources