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Review

Guide to NCL In Vivo Studies: Efficacy, Pharmacokinetics & Toxicology

Stern Stephan T.
In: National Cancer Institute’s Nanotechnology Characterization Laboratory Assay Cascade Protocols [Internet]. Bethesda (MD): National Cancer Institute (US); 2005 May.
2022 Sep.
Free Books & Documents
Review

Guide to NCL In Vivo Studies: Efficacy, Pharmacokinetics & Toxicology

Stern Stephan T..
Free Books & Documents

Excerpt

Novel nanoformulated chemotherapeutics and diagnostics require demonstration of efficacy and safety in appropriate animal models prior to clinical translation of the concept. Pharmacokinetic studies are also important to optimize dosing regimen and dose escalation strategy, and identify potential species differences. NCL’s in vivo experiments are tailored specifically to the individual nanoparticle under study. As such, a standard experimental protocol cannot be generated. Instead of a protocol, we offer the following general guidance for experimental design and data analysis. The following description is not a protocol and does not describe all of the relevant experimental parameters necessary to conduct the experiment. If you would like additional information, please feel free to contact us.

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