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Review
. 2023 Dec:168:115764.
doi: 10.1016/j.biopha.2023.115764. Epub 2023 Oct 26.

Biochemical aspects of the inflammatory process: A narrative review

Caroline Leal Rodrigues Soares  1 , Polrat Wilairatana  2 , Larissa Rodrigues Silva  1 , Polyanna Silva Moreira  1 , Nayana Maria Medeiros Vilar Barbosa  1 , Pablo Rayff da Silva  1 , Henrique Douglas Melo Coutinho  3 , Irwin Rose Alencar de Menezes  4 , Cícero Francisco Bezerra Felipe  5
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Free article
Review

Biochemical aspects of the inflammatory process: A narrative review

Caroline Leal Rodrigues Soares et al. Biomed Pharmacother. 2023 Dec.
Free article

Abstract

Inflammation is a protective response of the body potentially caused by microbial, viral, or fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of inflammation are consequences of immunological, biochemical, and physiological changes that trigger the release of pro-inflammatory chemical mediators at the local of the injured site thus, increasing blood flow, vascular permeability, and leukocyte recruitment. The aim of this study is to give an overview of the inflammatory process, focusing on chemical mediators. The literature review was based on a search of journals published between the years 2009 and 2023, regarding the role of major chemical mediators in the inflammatory process and current studies in pathogenesis, diagnosis, and therapy. Some of the recent contributions in the study of inflammatory pathologies and their mediators, including cytokines and chemokines, the kinin system, free radicals, nitric oxide, histamine, cell adhesion molecules, leukotrienes, prostaglandins and the complement system and their role in human health and chronic diseases.

Keywords: Inflammation; Inflammatory diseases; Inflammatory mediators; Inflammatory process; Review.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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